For research use only.

Catalog No.S1734

2 publications

Meloxicam Chemical Structure

CAS No. 71125-38-7

Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.

Selleck's Meloxicam has been cited by 2 publications

1 Customer Review

  • Meloxicam (0.25 μg/ml) decreases the migration of CF41.Mg cells. Incubation with 0.25 μg/ml meloxicam for 24 and 48 h inhibited the migration of cells compared with the DMSO‑treated control cells in a wound healing assay. A total of 6 repeats were performed and results are presented as the mean ± standard deviation. Representative images of the wound healing assay and quantification if the results are presented. Scale bar, 90 μm. *P<0.05 vs. the control group.

    Oncology letters, 2017, 2198-2206. Meloxicam purchased from Selleck.

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Biological Activity

Description Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
COX [1]
In vitro

Meloxicam significantly reduces HCA-7 and Moser-S colony size. Meloxicam significantly inhibits HCA-7 colony and tumor growth but has no effect on the growth of the COX-2 negative HCT-116 cells. [1] Meloxicam inhibits PGE(2) production, proliferation and invasiveness especially in MG-63 cells, which express relatively high levels of COX-2. Meloxicam causes apoptosis and upregulates Bax mRNA and protein in MG-63 cell culture. [2]

In vivo Meloxicam suppresses LM-8 tumor growth and lung metastasis in vivo mouse model. [2] Meloxicam causes a significant reduction in lameness at post injection hour (PIH) 8 and 24 and tends to reduce effusion in horse. Meloxicam significantly suppresses synovial fluid (SF) prostaglandin E2 and substance P release at PIH 8 and bradykinin at PIH 24 compared to placebo treatment in horse. Meloxicam reduces general MMP activity at PIH 8 and 24 in horse. [3] Meloxicam- or flunixin-treated horses has improved postoperative pain scores and clinical variables, compared with SS-treated horses. Meloxicam results in high numbers of neutrophils in ischemia-injured tissue of horse. [4] Meloxicam administration significantly suppresses PGE2 concentrations in blood and synovial fluid at days 7 and 21, but has no effect on concentrations of TXB2 in blood or PGE2 in gastric mucosa in dogs. [5]


Solubility (25°C)

In vitro DMSO 30 mg/mL (85.37 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 351.4


CAS No. 71125-38-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04322175 Active not recruiting Drug: Meloxicam Healthy Volunteers Beijing Tongren Hospital December 16 2019 Phase 1
NCT02405793 Withdrawn Drug: Meloxicam Test Capsules|Drug: Meloxicam Tablets Osteoarthritis Iroko Pharmaceuticals LLC May 2015 Phase 2

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID