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ML-180

Name: ML-180
Brand: Selleck Chemicals
SKU: S0989
Rating: 5 (1 reviews)

Synonyms: SR1848

Catalog No.S0989 Purity: 99.98%

ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers.

ML-180 Chemical Structure

CAS: 863588-32-3

Purity & Quality Control

Batch: S098901 DMSO] 10 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.98%

99.98

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Biological Activity

Description

ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers.

Targets

LRH1 ^[1]
(Cell-free assay)

3.7 μM

References

[1] Scott Busby, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Oct 12.

Chemical Information & Solubility

Molecular Weight	388.89	Formula	C₂₀H₂₅ClN₄O₂
CAS No.	863588-32-3	SDF	--
Smiles	C1CCC(CC1)N2C(=O)C=C(NC2=O)N3CCN(CC3)C4=CC(=CC=C4)Cl
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 10 mg/mL ( (25.71 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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