Home Metabolism Mitochondrial Metabolism modulator Mitochondrial Fusion Promoter M1 For research use only.

Mitochondrial Fusion Promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.

Mitochondrial Fusion Promoter M1 Chemical Structure

Mitochondrial Fusion Promoter M1 Chemical Structure

CAS: 219315-22-7

Selleck's Mitochondrial Fusion Promoter M1 has been cited by 2 publications

Purity & Quality Control

Batch: S337501 DMSO] 73 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.93%
99.93

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Biological Activity

Description Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.
In vitro
In vitro

Mitochondrial Fusion Promoter M1 prevents the cholesterol mediated blunting of cellular respiration and potentiates Glucose stimulated insulin secretion which is abolished in pancreatic beta cells on cholesterol accumulation.[2]
Cell Research Cell lines BRIN-BD11 cells
Concentrations 20 μM
Incubation Time 12 h
Method

BRIN-BD11 cells are first treated with Mitochondrial Fusion Promoter M1 for 12 h and then cholesterol (160 μM) is added to the media for another 12 h before various assays.
In Vivo
In vivo

Pretreatment with Mitochondrial Fusion Promoter M1 effectively increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction, BBB breakdown, macrophage infiltration, apoptosis, and AD-related proteins in rats following cardiac I/R injury.[1]

Chemical Information & Solubility

Molecular Weight 364.05 Formula

C14H10Cl4N2O
CAS No. 219315-22-7 SDF --
Smiles CC(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)\C2=C(O)C=CC(=C2)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 73 mg/mL ( (200.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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