Home Neuronal Signaling Cholinesterase (ChE) chemical 4-Methylbenzylidene camphor

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4-Methylbenzylidene camphor Cholinesterase (ChE) chemical

Cat.No.S3704

4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
4-Methylbenzylidene camphor Cholinesterase (ChE) chemical Chemical Structure

Chemical Structure

Molecular Weight: 254.37

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Quality Control

Batch: S370401 DMSO]50 mg/mL]false]Ethanol]50 mg/mL]false]Water]Insoluble]false Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (196.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
% Tween 80
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 254.37 Formula

C18H22O

 Storage (From the date of receipt)
CAS No. 36861-47-9 Download SDF Storage of Stock Solutions

Synonyms Enzacamene, 4-MBC Smiles CC1=CC=C(C=C1)C=C2C3CCC(C2=O)(C3(C)C)C

Mechanism of Action

In vivo
Though 4MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects comparable to E2 after chronic application. 4MBC is resorbed through the skin after dermal administration resulting in identical biotransformation of this UV filter in humans and rats. 4MBC is a potent inhibitor of the pituitary-thyroid-axis. 4-MBC prevents bone loss and exerted a very weak estrogenic effect on the uterus and the vagina after a 3-month treatment of Ovx rats. 4-MBC exerts a positive effect on the mitochondria and microstructure of the skeletal muscle during the early stage of osteoporotic fracture healing.
References

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