Molnupiravir (EIDD-2801)

For research use only.

Catalog No.S8969 Synonyms: MK-4482

Molnupiravir (EIDD-2801) Chemical Structure

CAS No. 2349386-89-4

Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.

Purity & Quality Control

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Biological Activity

Description Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.
Targets
SARS-CoV-2 [1]
()
MERS-CoV [1]
()
SARS-CoV [1]
()
In vitro

EIDD-2801 is an orally bioavailable NHC-prodrug. NHC is potently antiviral against SARS-CoV-2, MERS-CoV and SARS-CoV in primary human epithelial cell cultures without cytotoxicity. NHC is effective against remdesivir (RDV)-resistant vi-rus and multiple distinct zoonotic CoV. NHC antiviral activity is associated with increased viral mutation rates.[1]

In vivo

EIDD-2801 is efficiently hydrolyzed in vivo after absorption, resulting in detection of only free NHC in plasma.[2] Therapeutic EIDD-2801 is potently antiviral against SARS-CoV in vivo but the degree of clinical benefit is dependent on the time of initiation post-infection. EIDD-2801 robustly reduces MERS-CoV infectious titers, viral RNA, and pathogenesis under both prophylactic and early therapeutic conditions.[1]

Protocol

Animal Research:

[1]

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  • Animal Models: 20-29 week old SPF C57BL/6J mice, 10-14 week old C57BL/6J hDPP4 mice
  • Dosages: 50 mg/kg, 150 mg/kg, 500 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 66 mg/mL (200.41 mM)
Water 20 mg/mL (60.73 mM)
Ethanol '''22 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 329.31
Formula

C13H19N3O7

CAS No. 2349386-89-4
Storage powder
in solvent
Synonyms MK-4482
Smiles CC(C)C(=O)OCC1C(C(C(O1)N2C=CC(=NC2=O)NO)O)O

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04405739 Recruiting Drug: EIDD-2801|Drug: Placebo SARS-CoV 2 Ridgeback Biotherapeutics LP June 16 2020 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID