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Molnupiravir (EIDD-2801) SARS-CoV inhibitor

Name: Molnupiravir (EIDD-2801)
Brand: Selleck Chemicals
SKU: S8969
Availability: InStock
Rating: 5 (15 reviews)

Cat.No.S8969

Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N⁴-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.

Chemical Structure

Molecular Weight: 329.31

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Quality Control

Batch: Purity: 99.89%

99.89

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV
Other SARS-CoV Inhibitors	Nirmatrelvir (PF-07321332) EIDD-1931 (NHC) Paquinimod (ABR-215757) Ensitrelvir fumarate Lufotrelvir (PF-07304814) Simnotrelvir Ensitrelvir ML188 XP-59 GS-621763

Solubility

In vitro
Batch:

DMSO : 66 mg/mL (200.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 22 mg/mL

Water : 20 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.300mg/ml (10.02mM)
	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.330mg/ml (1.00mM)
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	329.31	Formula	C₁₃H₁₉N₃O₇	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2349386-89-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	MK-4482			SMILES	CC(C)C(=O)OCC1C(C(C(O1)N2C=CC(=NC2=O)NO)O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	SARS-CoV-2 MERS-CoV SARS-CoV
In vitro	Molnupiravir (EIDD-2801) is an orally bioavailable NHC-prodrug. This compound is potently antiviral against SARS-CoV-2, MERS-CoV and SARS-CoV in primary human epithelial cell cultures without cytotoxicity. It is effective against remdesivir (RDV)-resistant virus and multiple distinct zoonotic CoV. Its antiviral activity is associated with increased viral mutation rates.
In vivo	Molnupiravir (EIDD-2801) is efficiently hydrolyzed in vivo after absorption, resulting in detection of only free NHC in plasma. This compound is potently antiviral against SARS-CoV in vivo but the degree of clinical benefit is dependent on the time of initiation post-infection. It robustly reduces MERS-CoV infectious titers, viral RNA, and pathogenesis under both prophylactic and early therapeutic conditions.
References	[1] https://pubmed.ncbi.nlm.nih.gov/32253226/ [2] https://pubmed.ncbi.nlm.nih.gov/31645453/ [3] https://pubmed.ncbi.nlm.nih.gov/35598779/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-28)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06667700	RECRUITING	Coronavirus Disease (COVID-19)	Merck Sharp & Dohme LLC	2024-12-02	PHASE3
NCT06551844	RECRUITING	Dengue; Antiviral Drugs	Oxford University Clinical Research Unit, Vietnam	2026-04-20	PHASE2
NCT04381936	RECRUITING	Pneumonia	University of Oxford	2020-03-19	PHASE3
NCT04746183	RECRUITING	Covid19	University of Liverpool	2020-07-03	PHASE1; PHASE2
NCT05648448	RECRUITING	Influenza; Influenza, Human	University of Oxford	2023-02-22	PHASE2
NCT06488300	RECRUITING	Respiratory Syncytial Virus; Respiratory Syncytial Virus, Human	University of Oxford	2024-07-25	PHASE2

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Handling Instructions

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