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Menadione bisulfite sodium phosphatase inhibitor

Name: Menadione bisulfite sodium
Brand: Selleck Chemicals
SKU: S5953
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S5953

Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

Chemical Structure

Molecular Weight: 276.24

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Quality Control

Batch: S595301 DMSO]55 mg/mL]false]Water]55 mg/mL]false]Ethanol]Insoluble]false Purity: 99.92%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.92

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Drug Metabolite
Other phosphatase Inhibitors	Osunprotafib (ABBV-CLS-484) SHP099 Hydrochloride RMC-4550 SHP099 GSK2830371 β-Glycerophosphate sodium salt hydrate NSC87877 Batoprotafib (TNO155) TPI-1 Sanguinarine chloride

Solubility

In vitro
Batch:

DMSO : 55 mg/mL (199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 55 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	276.24	Formula	C₁₁H₉NaO₅S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	130-37-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Menadione sodium bisulfite, Vitamin K3 sodium bisulfite			Smiles	[Na+].CC1(CC(=O)C2=CC=CC=C2C1=O)[S]([O-])(=O)=O

Mechanism of Action

Targets/IC₅₀/Ki	Cdc25 phosphatase pol γ
References	[1] https://www.sciencedirect.com/science/article/abs/pii/S0045206896910524 [2] https://pubmed.ncbi.nlm.nih.gov/24520419/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01094444	Completed	Folliculitis	Per Pfeiffer\|Odense University Hospital	May 2010	Phase 2
NCT00656786	Completed	EGFR Inhibitor-associated Rash	Spectrum Pharmaceuticals Inc	April 3 2008	Phase 1

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