For research use only.

Catalog No.S2016 Synonyms: Org3770

Mirtazapine Chemical Structure

Molecular Weight(MW): 265.35

Mirtazapine is an adrenergic and seroton receptor antagonist, used to treat depression.

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10mM (1mL in DMSO) USD 90 In stock
USD 70 In stock
USD 270 In stock
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Biological Activity

Description Mirtazapine is an adrenergic and seroton receptor antagonist, used to treat depression.
5-HT [1]
In vitro

Mirtazapine displays marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocks noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Mirtazapine shows high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolishes 5-HT-induced phosphoinositide generation. Mirtazapine markedly elevates dialysate levels of NA and, in FCX, DA, whereas 5-HT is not affected.[1] Mirtazapine enhances the effectiveness of the electrical stimulation of the ascending 5-HT pathway by blocking both alpha-2 adrenergic auto- and heteroreceptors. Mirtazapine blocks the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors. [2]

In vivo Mirtazapine (10-250 mg/kg i.v.) enhances dose-dependently the firing activity of the 5-HT neurons in naive rats, but not in 6-hydroxydopamine-pretreated rats. [2] Mirtazapine (5 mg/kg/day, s.c., using osmotic minipumps) increases the spontaneous firing activity of locus coeruleus noradrenaline (NA) neurons in male Sprague-Dawley rats. Mirtazapine antagonizes both the enhancing effect of a low dose (10 mg/kg, i.v.) and the reducing effect of a high dose (100 mg/kg, i.v.) of the alpha 2-adrenoceptor agonist clonidine on the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of dorsal hippocampus CA3 pyramidal neurons. [3] Mirtazapine (5 mg/kg s.c.) only slightly affects DOPAC and homovanillic acid levels in the striatum, hardly affects 5-HT release in freely moving rats, but clearly increased 5-hydroxyindole acetic acid. [4]


Solubility (25°C)

In vitro DMSO 53 mg/mL (199.73 mM)
Ethanol 53 mg/mL (199.73 mM)
Water Insoluble

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Chemical Information

Molecular Weight 265.35


CAS No. 85650-52-8
Storage powder
in solvent
Synonyms Org3770
Smiles CN1CCN2C(C1)C3=C(CC4=C2N=CC=C4)C=CC=C3

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03785691 Recruiting Drug: Mirtazapine|Drug: Ondansetron|Drug: Placebo Hyperemesis Gravidarum|Nausea Gravidarum|Vomiting of Pregnancy Nordsjaellands Hospital|Bispebjerg Hospital|Aalborg University Hospital|Aarhus University Hospital|Herlev and Gentofte Hospital|Hvidovre University Hospital|Odense University Hospital|Rigshospitalet Denmark|Regionernes Medicinpulje|Kolding Sygehus March 1 2019 Phase 2
NCT03935685 Recruiting Drug: Mirtazapine (Remeron) Glioma of Brain University of California Irvine February 26 2019 Early Phase 1
NCT02336750 Recruiting Drug: Aprepitant|Drug: Mirtazapine Breast Cancer Fudan University December 2014 Phase 3

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5-HT Receptor Signaling Pathway Map

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