Home Transmembrane Transporters TRP Channel activator MK6-83 For research use only.

MK6-83

MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.

MK6-83 Chemical Structure

MK6-83 Chemical Structure

CAS: 1062271-24-2

Purity & Quality Control

Batch: S694701 DMSO] 11 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.34%
99.34

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Biological Activity

Description MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.
Targets
TRPML1 [1]
In vitro
In vitro

MK6-83 activates MCOLN1 and triggers cell death of a number of cancer cells by evoking autophagic arrest and subsequent apoptotic response and cell cycle arrest, with little or no effect observed on normal cells.[2]
Cell Research Cell lines HeLa cells, Cos-1 cells, HEK 293 T cells, Patu 8988 t cells, and HPDE6c7 cells
Concentrations 5 μM
Incubation Time 30 min, 90 min, 4 h and 12 h
Method

TFEB activity was not altered following ML-SA5 (1 μM), or ML-SA1 (20 μM), or MK6-83 (5 μM) treatments at 30 min, 90 min, 4 h and 12 h, as assessed by a TFEB-luciferase assay.

Chemical Information & Solubility

Molecular Weight 336.47 Formula

C16H20N2O2S2
CAS No. 1062271-24-2 SDF --
Smiles CC1=CC=C(S1)[S](=O)(=O)NC2=CC=CC=C2N3CCCCC3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 11 mg/mL ( (32.69 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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