6-Methylcoumarin

Synonyms: Toncarine

6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.

6-Methylcoumarin Chemical Structure

6-Methylcoumarin Chemical Structure

CAS No. 92-48-8

Purity & Quality Control

Batch: S480201 DMSO]32 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

6-Methylcoumarin Related Products

Biological Activity

Description 6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.
In vitro
In vitro Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that 6-Methylcoumarin could be transported across the gut wall by passive diffusion[1].
In Vivo
In vivo The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T1/2) lower that 120 min. 6-Methylcoumarin has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of 6-Methylcoumarin is 45% in Wistar rats[1].
Animal Research Animal Models Male Wistar rats
Dosages 200 mg/kg
Administration by oral gavage (p.o.) or intraperitoneal (i.p.) route

Chemical Information & Solubility

Molecular Weight 160.17 Formula

C10H8O2

CAS No. 92-48-8 SDF --
Smiles CC1=CC2=C(C=C1)OC(=O)C=C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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