6-Methylcoumarin

Name: 6-Methylcoumarin
Brand: Selleck Chemicals
SKU: S4802
Rating: 5 (1 reviews)

Synonyms: Toncarine

Catalog No.S4802 Purity: 99.99%

6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.

6-Methylcoumarin Chemical Structure

CAS: 92-48-8

Purity & Quality Control

Batch: S480201 DMSO] 32 mg/mL] false] ] ] false] ] ] false Purity: 99.99%

99.99

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Biological Activity

Description	6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.

In vitro
In vitro	Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that 6-Methylcoumarin could be transported across the gut wall by passive diffusion^[1].

In Vivo
In vivo	The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T_1/2) lower that 120 min. 6-Methylcoumarin has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of 6-Methylcoumarin is 45% in Wistar rats^[1].
Animal Research	Animal Models	Male Wistar rats
	Dosages	200 mg/kg
	Administration	by oral gavage (p.o.) or intraperitoneal (i.p.) route

References

[1] PA Cárdenas, et al. Braz J Pharm Sci. 2017, 53(1).

Chemical Information & Solubility

Molecular Weight	160.17	Formula	C₁₀H₈O₂
CAS No.	92-48-8	SDF	--
Smiles	CC1=CC2=C(C=C1)OC(=O)C=C2
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 32 mg/mL ( (199.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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