Methenamine Hippurate

Catalog No.S9466

For research use only.

Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.

Methenamine Hippurate Chemical Structure

CAS No. 5714-73-8

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 319.36
Formula

C15H21N5O3

CAS No. 5714-73-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04077580 Enrolling by invitation Drug: Methenamine Hippurate 1000 MG Recurrent Urinary Tract Infection University of Oslo|Amsterdam UMC location VUmc|UMC Utrecht|Göteborg University|Medical University of Lodz November 1 2019 Phase 4
NCT02358993 Completed Drug: methenamine hippurate|Drug: Ciprofloxacin Urinary Tract Infections|Catheter-Related Infections University of Pennsylvania December 2014 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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