Minoxidil

Catalog No.S1383 Synonyms: U-10858

For research use only.

Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Minoxidil is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth.

Minoxidil Chemical Structure

CAS No. 38304-91-5

Selleck's Minoxidil has been cited by 1 Publication

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Biological Activity

Description Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Minoxidil is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 0.25 mg/mL
(1.19 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 209.25
Formula

C9H15N5O

CAS No. 38304-91-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02198261 Completed Drug: 5% minoxidil topical foam Androgenetic Alopecia Applied Biology Inc. July 2014 --
NCT02206802 Completed Drug: 5% minoxidil topical foam Alopecia|Female Pattern Hair Loss Applied Biology Inc. July 2014 --
NCT01650272 Unknown status Drug: 5% MInoxidil milky lotion|Drug: 5% Minoxidil solution Objective (Goal)|Self-Assessment|Adverse Effects Siriraj Hospital June 2012 Phase 1|Phase 2
NCT01309191 Completed Drug: Minoxidil|Other: Placebo Androgenetic Alopecia University Hospitals Cleveland Medical Center|University of California San Francisco|Kaiser Permanente April 2011 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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