Molecular Weight(MW): 610.7
Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
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|Description||Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.|
Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer.  Manidipine inhibits the ET-1-induced [Ca2+]i increase by reducing both the transient and sustained Ca2+ increments in A7r5 cells and glomerular mesangial cells (MCs). Manidipine (10(-5) mol/L) potentiates ET-1-induced c-fos and c-jun expression in A7r5 cells. Manidipine is a potent inhibitor for ET-1-induced [Ca2+]i signaling and that Manidipine has multiple effects on ET-1-induced signaling, including potentiating the immediate-early gene response. 
|In vivo||Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion.  Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy.  Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats. |
-  Roth M, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 4071-4075.
-  Huang S, et al. Am Heart J, 1993, 125(2 Pt 2), 589-597.
-  Rossoni G, et al. Eur J Pharmacol, 2008, 587(1-3), 224-230.
|In vitro||DMSO||122 mg/mL (199.77 mM)|
|Ethanol||3 mg/mL (4.91 mM)|
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