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Manidipine Calcium Channel inhibitor

Cat.No.S2481

Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
Manidipine Calcium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 610.7

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Chemical Information, Storage & Stability

Molecular Weight 610.7 Formula

C35H38N4O6

Storage (From the date of receipt)
CAS No. 89226-50-6 Download SDF Storage of Stock Solutions

Synonyms CV-4093,(±)-Manidipine Smiles CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC

Solubility

In vitro
Batch:

DMSO : 122 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
Calcium channel [1]
2.6 nM
In vitro

Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer. [1] This compound inhibits the ET-1-induced [Ca2+]i increase by reducing both the transient and sustained Ca2+ increments in A7r5 cells and glomerular mesangial cells (MCs). It (10(-5) mol/L) potentiates ET-1-induced c-fos and c-jun expression in A7r5 cells. This chemical is a potent inhibitor for ET-1-induced [Ca2+]i signaling and that it has multiple effects on ET-1-induced signaling, including potentiating the immediate-early gene response. [2]
In vivo

Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. This compound combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. [3] This chemical prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. [4] It increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats. [5]
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/9559417/
  • [5] https://pubmed.ncbi.nlm.nih.gov/1282591/

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