Monomethyl auristatin E (MMAE)

Catalog No.S7721 Synonyms: SGD-1010

For research use only.

Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .

Monomethyl auristatin E (MMAE) Chemical Structure

CAS No. 474645-27-7

Selleck's Monomethyl auristatin E (MMAE) has been cited by 6 Publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .
In vitro

When coupled to cAC10, MMAE shows selective cytotoxicity in CD30+ cells, and induces G2/M-phase growth arrest and cell death through the induction of apoptosis. [1] When coupled to anti-CD79b antibody, anti–CD79b-vcMMAE has very potent and broad activity across a large panel of NHL cell lines in vitro. [2] When coupled to anti-HER2 antibody, hertuzumab-vc-MMAE can also be effectively internalized and potently kill HER2 over-expressing tumor cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{ToNlQh\GG7cx?= MlXiRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNQjDj[YxteyCjZoTldkA1KGSjeYOgZpkhYFSWIHHzd4F6NCCLQ{WwQVAvODByMUpOwG0> MlHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NEW3OFMoRjJ|OES1O|Q{RC:jPh?=
BT-12 MlLldWhVWyCjc4PhfS=> NGXwXWJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStNVIh[2WubIO= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh2NUe0N{c,OjN6NEW3OFM9N2F-
A549 M{DmfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3fGUVQh\GG7cx?= MoPURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDRiZHH5d{BjgSC[VGSgZZN{[XluIFnDOVA:OC5yMEC1Pe69VQ>? NHzX[oU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0OVc1Oyd-MkO4OFU4PDN:L3G+
non-small cell lung cancer cells M1fNOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYjVflVSOC53IITvJFEhdk1? NGK0c3g1KGSjeYO= MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDuc44ue22jbHygZ4VtdCCudX7nJINidmOncjDj[YxteyCjdDCwMlUhfG9iMTDuUUBi\nSncjC0JIRigXNiYomgXHRVKGG|c3H5 NHfjcno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0OVc1Oyd-MkO4OFU4PDN:L3G+
A673 M3jtTJFJXFNiYYPzZZk> MkS4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEF4N{OgZ4VtdHN? MnOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2M{G4OVgoRjJ3NEOxPFU5RC:jPh?=
MDA-MB-361 NIPwWVdEgXSxdH;4bYNqfHliYYPzZZk> MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5JmKDRiZHH5d{BjgSCPVGOgZZN{[XluIFfJOVA:OC5yMEC0Pe69VQ>? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR|MUi1PEc,OjV2M{G4OVg9N2F-
NCI-N87 MkThR5l1d3SxeHnjbZR6KGG|c3H5 M{jjTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2QOEegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdoUhPCCmYYnzJIJ6KE2WUzDhd5NigSxiR1m1NF0xNjByMEW0{txO MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR|MUi1PEc,OjV2M{G4OVg9N2F-
OHS-50 MmP2dWhVWyCjc4PhfS=> M2DXVZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCRSGOtOVAh[2WubIO= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJzMUK3O{c,Ojh{MUGyO|c9N2F-
DU145 NEW3[|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHLhWXE1QCCqcoO= NFvueWlIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFXTF2NTDj[YxteyCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBOXFRiYYPzZZktKEeLNUC9NE4xODB2MUlOwG0> NVXWPJFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNVEzPzdpPkK4NlEyOjd5PD;hQi=>
SF268 MnrVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITqflU1QCCqcoO= NH62cplIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxteyCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBOXFRiYYPzZZktKEeLNUC9NE4xODB2M{NOwG0> MoLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUGyO|coRjJ6MkGxNlc4RC:jPh?=
KM20L2 MlzUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYS0PEBpenN? NUTxTZpKT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hU01{MFyyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0xNjByMEW5Pe69VQ>? NGT5U409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxNVI4Pyd-MkiyNVEzPzd:L3G+
NCI-H460 MoXoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkXGOFghcHK| M1rY[Wdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0xNjByME[4N:69VQ>? MnX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUGyO|coRjJ6MkGxNlc4RC:jPh?=
HCT116 MW\GeY5kfGmxbjDhd5NigQ>? M2\lUFAvPSCvTR?= M{LmO|I1KGi{cx?= M2HsWmVn\mWldDDvckBucXSxY3jvcoRzcWGuIILld5BqemG2aX;uJIlvKGi3bXHuJGhEXDFzNjDj[YxteyCneIDy[ZN{cW6pIHPhdoJwdmmlIHHubJllemG|ZTC5JIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDvfJlo\W5iY3;ud5VueHSrb36gdoF1\SCjdDCwMlUhdU1iYX\0[ZIhOjRiaILzJJVv\GW{IHj5dI95cWNiY3;u[Il1cW:wIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NEDTfHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi5OVM6PCd-Mki4PVU{QTR:L3G+
DU145 MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfI[WxJPDhiaILz MoPCS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSHUyPDViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlAxODRzON88US=> NGfaRo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi5OVM6PCd-Mki4PVU{QTR:L3G+
SF268 MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUO0PEBpenN? NXjSTHpQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NF0xNjByMESzNu69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh7NUO5OEc,Ojh6OUWzPVQ9N2F-
KM20L2 M4rveWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVi0PEBpenN? M1\ocmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGtOOjCOMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvODByNUm5{txO NXvBbog3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4PVU{QTRpPkK4PFk2Ozl2PD;hQi=>
NCI-H460 NF3kXmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWG0PEBpenN? NWPkfVZLT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OD1yLkCwNFY5O87:TR?= M2PWXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEm1N|k1Lz5{OEi5OVM6PDxxYU6=
MCF7 MlHsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M370U|Q5KGi{cx?= MmTyS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUCuNFAxPDB2zszN NVXaO2JWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlYzPDBpPkK4PVI3OjRyPD;hQi=>
DU145 NF:1Ro5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPV[W9MPDhiaILz MWXHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUCuNFAxPDF6zszN M1rGNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK2NlQxLz5{OEmyOlI1ODxxYU6=
SF268 Ml7TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIexdoM1QCCqcoO= NGnkepdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvODByNEOy{txO MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{NkK0NEc,Ojh7Mk[yOFA9N2F-
KM20L2 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnYWHJ5PDhiaILz M{PIWGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGtOOjCOMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvODByNUm5{txO MnLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mk[yOFAoRjJ6OUK2NlQxRC:jPh?=
NCI-H460 NGTYZ2VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmDIOFghcHK| NFTLPHhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSES2NEBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxRTBwMECwOlg{|ryP MorEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mk[yOFAoRjJ6OUK2NlQxRC:jPh?=
DAOY MnfYdWhVWyCjc4PhfS=> M4jCWpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCGQV;ZJINmdGy| NXTDWWg2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5O|I4PTVpPkK4PVczPzV3PD;hQi=>
A549 M1TKTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnPTO|IhcHK| MkfaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFXDOVA:OC5yMEC1{txO NYrkNHVSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5O|I4PTVpPkK4PVczPzV3PD;hQi=>
SKOV3 MlLDR5l1d3SxeHnjbZR6KGG|c3H5 M3PhNlIh\GG7cx?= M{PYVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KGGodHXyJFIh\GG7czDifUBk\WyuIITpeIVzKDl4IHHxeYVwfXNib37lJJNwdHW2aX;uJIJie2WmIHHzd4F6NCCLQ{WwQVAvODByNkdOwG0> NUXpXVNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0OVQ4ODNpPkK5OFU1PzB|PD;hQi=>
A549 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MX:yJIRigXN? NWXLfVlFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzKGSjeYOgZpkh[2WubDD0bZRmeiB7NjDhdZVmd3W|IH;u[UB{d2y3dHnvckBj[XOnZDDhd5NigSxiSVO1NF0xNjByMUROwG0> NIf1W5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1OFcxOyd-Mkm0OVQ4ODN:L3G+
L1210 NVm4em5nS3m2b4TvfIlkcXS7IHHzd4F6 NG\HdlMzKGSjeYO= NYTRUm9KS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVDF{MUCgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGOnbHygeIl1\XJiOU[gZZF2\W:3czDvcoUhe2:udYTpc44h[mG|ZXSgZZN{[XluIFnDOVA:OC5yMEKx{txO NFj0d|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1OFcxOyd-Mkm0OVQ4ODN:L3G+
NCI-H524 MmPQR5l1d3SxeHnjbZR6KGG|c3H5 MUiyJIhzew>? NVzPU3ZXS3m2b4TvfIlkcXS7IHnuJIh2dWGwIF7DTU1JPTJ2IHPlcIx{KHC{ZT3pcoN2[mG2ZXSg[o9zKDJiaILzJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHejc3igc5V1KGGwZDDzeYJ{\XG3ZX70cJkhcW6ldXLheIVlKG[xcjC3NEBpenNiYomgR4VtdCCWaYTldkBIdG9iYYPzZZktKEmFNUC9NE4xODN5zszN NH;DboE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEezOVM5PSd-M{C3N|U{QDV:L3G+
In vivo In the Karpas 299 ALCL model, cAC10-vcMMAE (1 mg/kg, i.v.) induces complete, durable tumor regression, while free MMAE (0.36 mg/kg) doesn’t produce detectable antitumor activity. [1] In mouse xenograft models of NHL, anti–CD79b-vcMMAE (7 mg/kg, p.o.) strikingly results in sustained complete tumor remission. [2]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: CD30+ Karpas 299 cells
  • Concentrations: ~1000 ng/mL
  • Incubation Time: 96 h
  • Method:

    Cytotoxicity is measured using Alamar Blue dye reduction assay according to the manufacturer's directions. Briefly, a 40% solution (wt/vol) of Alamar Blue is freshly prepared in complete media just before cultures are added. Ninety-two hours after drug exposure, Alamar Blue solution is added to cells to constitute 10% culture volume. Cells are incubated for 4 hours, and dye reduction is measured on a Fusion HT fluorescent plate reader (Packard Instruments, Meriden, CT).

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 717.98
Formula
C39H67N5O7
 
CAS No. 474645-27-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05514158 Recruiting Drug: RC48-ADC|Drug: RC98 Gastric Cancer RemeGen Co. Ltd. October 30 2022 Phase 1
NCT05216965 Recruiting Drug: 9MW2821 Solid Tumors Mabwell (Shanghai) Bioscience Co. Ltd. June 11 2022 Phase 1|Phase 2
NCT05126719 Recruiting Drug: MRG003 Recurrent or Metastatic Nasopharyngeal Carcinoma Shanghai Miracogen Inc. August 4 2021 Phase 2
NCT05188209 Recruiting Drug: MRG003 Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Carcinoma Shanghai Miracogen Inc. May 24 2021 Phase 2
NCT04492488 Recruiting Drug: MRG002 Advanced Solid Tumors|Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Cancer Shanghai Miracogen Inc. May 24 2021 Phase 1|Phase 2
NCT04868162 Recruiting Drug: MRG003 Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck Shanghai Miracogen Inc. April 23 2021 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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