Monomethyl auristatin E (MMAE)

Catalog No.S7721 Synonyms: SGD-1010

For research use only.

Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .

Monomethyl auristatin E (MMAE) Chemical Structure

CAS No. 474645-27-7

Selleck's Monomethyl auristatin E (MMAE) has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .
In vitro

When coupled to cAC10, MMAE shows selective cytotoxicity in CD30+ cells, and induces G2/M-phase growth arrest and cell death through the induction of apoptosis. [1] When coupled to anti-CD79b antibody, anti–CD79b-vcMMAE has very potent and broad activity across a large panel of NHL cell lines in vitro. [2] When coupled to anti-HER2 antibody, hertuzumab-vc-MMAE can also be effectively internalized and potently kill HER2 over-expressing tumor cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KB NVnQdoZMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWi0JIRigXN? MlP1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNQjDj[YxteyCjZoTldkA1KGSjeYOgZpkhYFSWIHHzd4F6NCCLQ{WwQVAvODByMUpOwG0> MnfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NEW3OFMoRjJ|OES1O|Q{RC:jPh?=
BT-12 M{LHZpFJXFNiYYPzZZk> MoPRdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy| M4TXbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OES1O|Q{Lz5{M{i0OVc1OzxxYU6=
A549 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3\sSVQh\GG7cx?= NVvPTFhmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDYWHQh[XO|YYmsJGlEPTB;MD6wNFA2Qc7:TR?= NH;uNYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i0OVc1Oyd-MkO4OFU4PDN:L3G+
non-small cell lung cancer cells MV7DfZRwfG:6aXPpeJkh[XO|YYm= NWjLR2lEOC53IITvJFEhdk1? MlvnOEBl[Xm| NHTUb|lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBvd25vc33hcIwh[2WubDDseY5oKGOjbnPldkBk\WyuczDheEAxNjVidH:gNUBvVSCjZoTldkA1KGSjeYOgZpkhYFSWIHHzd4F6 M1S3SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OES1O|Q{Lz5{M{i0OVc1OzxxYU6=
A673 NGLC[pJyUFSVIHHzd4F6 NW\GOYdLeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFG2O|Mh[2WubIO= NEHi[Fc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSzNVg2QCd-MkW0N|E5PTh:L3G+
MDA-MB-361 NVHT[WVDS3m2b4TvfIlkcXS7IHHzd4F6 M{P1OmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2zOlEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZwemViNDDkZZl{KGK7IF3UV{Bie3OjeTygS2k2OD1yLkCwNFQ6|ryP Ml7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2M{G4OVgoRjJ3NEOxPFU5RC:jPh?=
NCI-N87 NGLJZmpEgXSxdH;4bYNqfHliYYPzZZk> M{XXdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2QOEegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdoUhPCCmYYnzJIJ6KE2WUzDhd5NigSxiR1m1NF0xNjByMEW0{txO NF[3XW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSzNVg2QCd-MkW0N|E5PTh:L3G+
OHS-50 NHrDU3ByUFSVIHHzd4F6 M{nSTJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCRSGOtOVAh[2WubIO= NGn0XW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKxNVI4Pyd-MkiyNVEzPzd:L3G+
DU145 M4G0bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUS0PEBpenN? Mkn0S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gSHUyPDViY3XscJMhcW6ldXLheIVlKG[xcjC0PEBpenNiYomgUXRVKGG|c3H5MEBIUTVyPUCuNFAxPDF6zszN M3zlNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkGxNlc4Lz5{OEKxNVI4PzxxYU6=
SF268 NHz6[JlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfPfJY1QCCqcoO= MYTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDTSlI3QCClZXzsd{BqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGdKPTB;MD6wNFA1OzMQvF2= NVi0dndFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNVEzPzdpPkK4NlEyOjd5PD;hQi=>
KM20L2 M1TsfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml71OFghcHK| MUfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDLUVIxVDJiY3XscJMhcW6ldXLheIVlKG[xcjC0PEBpenNiYomgUXRVKGG|c3H5MEBIUTVyPUCuNFAxPTl7zszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJzMUK3O{c,Ojh{MUGyO|c9N2F-
NCI-H460 MlziS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFnGfFc1QCCqcoO= NYixV4d5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubIOgbY5kfWKjdHXkJIZweiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTBwMECwOlg{|ryP MojjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MUGyO|coRjJ6MkGxNlc4RC:jPh?=
HCT116 M{nieGZ2dmO2aX;uJIF{e2G7 NGjHUI4xNjVibV2= M1;RXVI1KGi{cx?= Ml3vSYZn\WO2IH;uJI1qfG:laH;u[JJq[WxicnXzdIlz[XSrb36gbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGW6cILld5NqdmdiY3HyZo9vcWNiYX7ofYRz[XOnIEmgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIH;4fYdmdiClb37zeY1xfGmxbjDyZZRmKGG2IECuOUBuVSCjZoTldkAzPCCqcoOgeY5l\XJiaInwc5hq[yClb37kbZRqd25iYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh7NUO5OEc,Ojh6OUWzPVQ9N2F-
DU145 NFm0XHNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1PGRVQ5KGi{cx?= MU\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUCuNFAxPDF6zszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh7NUO5OEc,Ojh6OUWzPVQ9N2F-
SF268 NFztfVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYLGTZB2PDhiaILz M2\sUWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUC9NE4xODB2M{NOwG0> NIG4W3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi5OVM6PCd-Mki4PVU{QTR:L3G+
KM20L2 NXyxOIhvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\IOFghcHK| M4jt[Gdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGtOOjCOMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvODByNUm5{txO NHj4VG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi5OVM6PCd-Mki4PVU{QTR:L3G+
NCI-H460 M1uwcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYnubol6PDhiaILz MlLkS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NF0xNjByME[4N:69VQ>? MoTjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6OUWzPVQoRjJ6OEm1N|k1RC:jPh?=
MCF7 M1vTRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\sb|Q5KGi{cx?= NITmXG9Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUC9NE4xODB2MEVOwG0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{NkK0NEc,Ojh7Mk[yOFA9N2F-
DU145 NVO5b|ZwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7ySFVPPDhiaILz NEiwemdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFXTF2NTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvODByNEG4{txO MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{NkK0NEc,Ojh7Mk[yOFA9N2F-
SF268 NWHYV5M2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVu0PEBpenN? NHL6SVRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvODByNEOy{txO NYr1T2tERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlYzPDBpPkK4PVI3OjRyPD;hQi=>
KM20L2 NY\DfWRWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHBeYh2PDhiaILz NUDoTlhGT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hU01{MFyyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVA:OC5yMEC1PVnPxE1? NXHycpRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlYzPDBpPkK4PVI3OjRyPD;hQi=>
NCI-H460 M4f4WGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfqOFghcHK| NUeyOFJFT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OD1yLkCwNFY5O87:TR?= NXTyV3hwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlYzPDBpPkK4PVI3OjRyPD;hQi=>
DAOY NEf2ToVyUFSVIHHzd4F6 NEPUblJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiRFHPXUBk\Wyucx?= M3nRe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUeyO|U2Lz5{OEm3Nlc2PTxxYU6=
A549 NFTzSIxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUG3NkBpenN? MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiRVO1NF0xNjByMEZOwG0> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl5Mke1OUc,Ojh7N{K3OVU9N2F-
SKOV3 MoPBR5l1d3SxeHnjbZR6KGG|c3H5 MX[yJIRigXN? NFPHRXpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCjZoTldkAzKGSjeYOgZpkh[2WubDD0bZRmeiB7NjDhdZVmd3W|IH;u[UB{d2y3dHnvckBj[XOnZDDhd5NigSxiSVO1NF0xNjByME[2{txO NHzKTlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1OFcxOyd-Mkm0OVQ4ODN:L3G+
A549 MVfDfZRwfG:6aXPpeJkh[XO|YYm= MVKyJIRigXN? Mm\qR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyJIRigXNiYomgZ4VtdCC2aYTldkA6PiCjcYXlc5V{KG:wZTDzc4x2fGmxbjDiZZNm\CCjc4PhfUwhUUN3ME2wMlAxOTQQvF2= NIHWU|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1OFcxOyd-Mkm0OVQ4ODN:L3G+
L1210 MULDfZRwfG:6aXPpeJkh[XO|YYm= MWiyJIRigXN? NXTx[ZVUS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVDF{MUCgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGOnbHygeIl1\XJiOU[gZZF2\W:3czDvcoUhe2:udYTpc44h[mG|ZXSgZZN{[XluIFnDOVA:OC5yMEKx{txO MnPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2NUS3NFMoRjJ7NEW0O|A{RC:jPh?=
NCI-H524 M4i1RmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGXCe4gzKGi{cx?= MXfDfZRwfG:6aXPpeJkhcW5iaIXtZY4hVkOLLVi1NlQh[2WubIOgdJJmNWmwY4XiZZRm\CCob4KgNkBpenNiZn;scI94\WRiYomgZ49ueG:3bnSge4F{cCCxdYSgZY5lKHO3YoPldZVmdnSueTDpcoN2[mG2ZXSg[o9zKDdyIHjyd{BjgSCFZXzsJHRqfGW{IFfsc{Bie3OjeTygTWM2OD1yLkCwN|fPxE1? NWO4dmhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3N|U{QDVpPkOwO|M2Ozh3PD;hQi=>
In vivo In the Karpas 299 ALCL model, cAC10-vcMMAE (1 mg/kg, i.v.) induces complete, durable tumor regression, while free MMAE (0.36 mg/kg) doesn’t produce detectable antitumor activity. [1] In mouse xenograft models of NHL, anti–CD79b-vcMMAE (7 mg/kg, p.o.) strikingly results in sustained complete tumor remission. [2]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: CD30+ Karpas 299 cells
  • Concentrations: ~1000 ng/mL
  • Incubation Time: 96 h
  • Method:

    Cytotoxicity is measured using Alamar Blue dye reduction assay according to the manufacturer's directions. Briefly, a 40% solution (wt/vol) of Alamar Blue is freshly prepared in complete media just before cultures are added. Ninety-two hours after drug exposure, Alamar Blue solution is added to cells to constitute 10% culture volume. Cells are incubated for 4 hours, and dye reduction is measured on a Fusion HT fluorescent plate reader (Packard Instruments, Meriden, CT).

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 717.98
Formula
C39H67N5O7
 
CAS No. 474645-27-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04879329 Not yet recruiting Drug: Disitamab vedotin Urothelial Carcinoma Seagen Inc.|RemeGen Co. Ltd. March 31 2022 Phase 2
NCT05126719 Recruiting Drug: MRG003 Recurrent or Metastatic Nasopharyngeal Carcinoma Shanghai Miracogen Inc. August 4 2021 Phase 2
NCT05188209 Recruiting Drug: MRG003 Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Carcinoma Shanghai Miracogen Inc. May 24 2021 Phase 2
NCT04492488 Recruiting Drug: MRG002 Advanced Solid Tumors|Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Cancer Shanghai Miracogen Inc. May 24 2021 Phase 1|Phase 2
NCT04868162 Recruiting Drug: MRG003 Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck Shanghai Miracogen Inc. April 23 2021 Phase 2
NCT04617314 Recruiting Drug: RC108 Solid Tumor RemeGen Co. Ltd. March 10 2021 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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