Mobocertinib (TAK788)

Catalog No.S6813 Synonyms: AP32788

For research use only.

Mobocertinib (TAK788, AP32788), an investigational TKI, is a potent, selective preclinical inhibitor of epidermal growth factor receptor (EGFR) and HER2 mutations. Mobocertinib (TAK788) is an antineoplastic agent.

Mobocertinib (TAK788) Chemical Structure

CAS No. 1847461-43-1

Selleck's Mobocertinib (TAK788) has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Mobocertinib (TAK788, AP32788), an investigational TKI, is a potent, selective preclinical inhibitor of epidermal growth factor receptor (EGFR) and HER2 mutations. Mobocertinib (TAK788) is an antineoplastic agent.
Targets
EGFR [1]
()
HER2 [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 9 mg/mL
(15.36 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 585.70
Formula

C32H39N7O4

CAS No. 1847461-43-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)OC(=O)C1=CN=C(N=C1C2=CN(C3=CC=CC=C32)C)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04576208 Withdrawn Drug: TAK-788|Drug: Antidiarrheal prophylaxis Non-Small Cell Lung Cancer (NSCLC) Takeda November 30 2020 Phase 2
NCT04441255 Completed Drug: TAK-788 Healthy Volunteers Takeda July 1 2020 Phase 1
NCT04056455 Recruiting Drug: Mobocertinib Renal Impairment|Healthy Volunteers Millennium Pharmaceuticals Inc.|Takeda March 10 2020 Phase 1
NCT04056468 Recruiting Drug: Mobocertinib Hepatic Impairment|Healthy Volunteers Millennium Pharmaceuticals Inc.|Takeda August 23 2019 Phase 1
NCT03928327 Completed Drug: TAK-788|Drug: Itraconazole|Drug: Rifampin Healthy Volunteers Millennium Pharmaceuticals Inc.|Takeda May 2 2019 Phase 1
NCT03807778 Active not recruiting Drug: TAK-788 Non-Small Cell Lung Cancer Takeda February 4 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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