Metoclopramide HCl

For research use only.

Catalog No.S4289

Metoclopramide HCl Chemical Structure

CAS No. 7232-21-5

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

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Biological Activity

Description Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
Targets
D2 receptor [1]

Protocol

References

Solubility (25°C)

In vitro DMSO 67 mg/mL warmed (199.25 mM)
Water 67 mg/mL (199.25 mM)
Ethanol 67 mg/mL (199.25 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 336.26
Formula

C14H23Cl2N3O2

CAS No. 7232-21-5
Storage powder
in solvent
Synonyms N/A
Smiles CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02466984 Completed Drug: metoclopramide intravenous Nausea|Vomiting University Hospital Bordeaux July 2016 Phase 3
NCT02253524 Completed Drug: Dimenhydrinate|Drug: Metoclopramide Nausea|Vomiting|Vertigo Pamukkale University November 2012 Phase 4
NCT01907633 Completed Drug: No intervention Death Sudden Cardiac Janssen Research & Development LLC December 2011 --
NCT01220388 Completed Dietary Supplement: L-lysine|Dietary Supplement: placebo Male|Healthy Volunteers University Hospital Rouen October 2010 Not Applicable
NCT01289938 Terminated Drug: Diphenhydramine|Drug: Metoclopramide Drug Metabolism Poor CYP2D6-RELATED Matthias Schwab|University Hospital Tuebingen July 2009 Phase 1

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID