Metoclopramide HCl

Catalog No.S4289

Metoclopramide HCl Chemical Structure

Molecular Weight(MW): 336.26

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

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Biological Activity

Description Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
D2 receptor [1]



Solubility (25°C)

In vitro DMSO 67 mg/mL warmed (199.25 mM)
Water 67 mg/mL (199.25 mM)
Ethanol 67 mg/mL (199.25 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 336.26


CAS No. 7232-21-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02466984 Completed Drug: metoclopramide intravenous Nausea|Vomiting University Hospital Bordeaux July 2016 Phase 3
NCT02253524 Completed Drug: Dimenhydrinate|Drug: Metoclopramide Nausea|Vomiting|Vertigo Pamukkale University November 2012 Phase 4
NCT01907633 Completed Drug: No intervention Death Sudden Cardiac Janssen Research & Development LLC December 2011 --
NCT01220388 Completed Dietary Supplement: L-lysine|Dietary Supplement: placebo Male|Healthy Volunteers University Hospital Rouen October 2010 Not Applicable
NCT01289938 Terminated Drug: Diphenhydramine|Drug: Metoclopramide Drug Metabolism Poor CYP2D6-RELATED Matthias Schwab|University Hospital Tuebingen July 2009 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID