MRT67307

Catalog No.S6386 Synonyms: IKKε/TBK1 Inhibitor II

For research use only.

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.

MRT67307 Chemical Structure

CAS No. 1190378-57-4

Selleck's MRT67307 has been cited by 1 Publication

Purity & Quality Control

Choose Selective TBK1 Inhibitors

Biological Activity

Description

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.

Targets
TBK1 [1]
(Cell-free assay)
ULK1 [2]
(Cell-free assay)
IKKϵ [1]
(Cell-free assay)
19 nM 45 nM 160 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 464.60
Formula

C26H36N6O2

CAS No. 1190378-57-4
Storage 3 years -20°C powder
2 years -80°C in solvent

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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