MRT67307

Synonyms: IKKε/TBK1 Inhibitor II

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.

MRT67307 Chemical Structure

MRT67307 Chemical Structure

CAS: 1190378-57-4

Selleck's MRT67307 has been cited by 2 publications

Purity & Quality Control

Batch: S638601 DMSO] 92 mg/mL] false] Ethanol] 92 mg/mL] false] Water] Insoluble] false Purity: 99.58%
99.58

MRT67307 Related Products

Choose Selective TBK1 Inhibitors

Biological Activity

Description

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.

Targets
TBK1 [1]
(Cell-free assay)
ULK1 [2]
(Cell-free assay)
IKKϵ [1]
(Cell-free assay)
19 nM 45 nM 160 nM

Chemical Information & Solubility

Molecular Weight 464.60 Formula

C26H36N6O2

CAS No. 1190378-57-4 SDF --
Smiles O=C(NCCCNC1=NC(=NC=C1C2CC2)NC3=CC=CC(=C3)CN4CCOCC4)C5CCC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (198.01 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 92 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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