For research use only.

Catalog No.S2125

Mestranol Chemical Structure

Molecular Weight(MW): 310.43

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.
Estrogen receptor [1]
In vitro

Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized. [1]

In vivo Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. [1] Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus. [2]


Solubility (25°C)

In vitro Ethanol 25 mg/mL (80.53 mM)
DMSO 15 mg/mL (48.32 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 310.43


CAS No. 72-33-3
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC2=C(C=C1)C3CCC4(C)C(CCC4(O)C#C)C3CC2

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Estrogen/progestogen Receptor Signaling Pathway Map

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