Metoclopramide hydrochloride hydrate

For research use only.

Catalog No.S5949 Synonyms: Clorpa, Gimoti, Maxolon, Reglan

1 publication

Metoclopramide hydrochloride hydrate Chemical Structure

CAS No. 54143-57-6

Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.

Selleck's Metoclopramide hydrochloride hydrate has been cited by 1 publication

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Biological Activity

Description Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.
Targets
Dopamine receptor [1]
()
5HT3 receptor [1]
()
5HT4 receptor [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 71 mg/mL (200.41 mM)
Water 71 mg/mL (200.41 mM)
Ethanol ''71 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 354.27
Formula

C14H25Cl2N3O3

CAS No. 54143-57-6
Storage powder
in solvent
Synonyms Clorpa, Gimoti, Maxolon, Reglan

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05008926 Not yet recruiting Drug: Naloxegol|Drug: Placebo Brain Injuries University Hospital Brest October 2021 Phase 3
NCT04771481 Not yet recruiting Drug: Metoclopramide|Drug: Normal Saline 10 mL Injection Acute Upper Gastrointestinal Bleeding|Effect of Drug King Chulalongkorn Memorial Hospital March 2021 Phase 4
NCT04748133 Recruiting Device: acupuncture needles|Other: placebo Treatment Complication Zagazig University February 20 2021 Not Applicable
NCT02466984 Completed Drug: metoclopramide intravenous Nausea|Vomiting University Hospital Bordeaux July 2016 Phase 3

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID