Metoclopramide hydrochloride hydrate

Catalog No.S5949 Synonyms: Clorpa, Gimoti, Maxolon, Reglan

For research use only.

Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.

Metoclopramide hydrochloride hydrate Chemical Structure

CAS No. 54143-57-6

Selleck's Metoclopramide hydrochloride hydrate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.
Targets
Dopamine receptor [1]
()
5HT3 receptor [1]
()
5HT4 receptor [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 71 mg/mL
(200.41 mM)
Water 71 mg/mL
(200.41 mM)
Ethanol ''71 mg/mL

Chemical Information

Molecular Weight 354.27
Formula

C14H25Cl2N3O3

CAS No. 54143-57-6
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05008926 Not yet recruiting Drug: Naloxegol|Drug: Placebo Brain Injuries University Hospital Brest October 2021 Phase 3
NCT04771481 Not yet recruiting Drug: Metoclopramide|Drug: Normal Saline 10 mL Injection Acute Upper Gastrointestinal Bleeding|Effect of Drug King Chulalongkorn Memorial Hospital March 2021 Phase 4
NCT04748133 Recruiting Device: acupuncture needles|Other: placebo Treatment Complication Zagazig University February 20 2021 Not Applicable
NCT02466984 Completed Drug: metoclopramide intravenous Nausea|Vomiting University Hospital Bordeaux July 2016 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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