Name: Metoclopramide hydrochloride hydrate
Brand: Selleck Chemicals
SKU: S5949
Rating: 5 (2 reviews)

Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.

Metoclopramide hydrochloride hydrate Chemical Structure

CAS: 54143-57-6

Selleck's Metoclopramide hydrochloride hydrate has been cited by 2 publications

Purity & Quality Control

Batch: S594901 DMSO] 71 mg/mL] false] Water] 71 mg/mL] false] Ethanol] 71 mg/mL] false Purity: 99.96%

99.96

Metoclopramide hydrochloride hydrate Related Products

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Signaling Pathway

Dopamine Receptor Signaling Pathway

Choose Selective Dopamine Receptor Inhibitors

Biological Activity

Description

Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.

Targets

Dopamine receptor ^[1]

5HT3 receptor ^[1]

5HT4 receptor ^[1]

In Vivo
In vivo	Metoclopramide attenuates MSG-induced lying-on-belly behaviours of rats.^[2]
Animal Research	Animal Models	Male and Female Sprague Dawley rats
	Dosages	5 mg/ml
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05759481	Not yet recruiting	Post-operative Nausea and Vomiting	Milton S. Hershey Medical Center	January 2024	Phase 2
NCT05832151	Recruiting	Diabetic Gastroparesis	CinDome Pharma Inc.	March 27 2023	Phase 2
NCT05008926	Recruiting	Brain Injuries	University Hospital Brest	March 15 2022	Phase 3
NCT04748133	Unknown status	Treatment Complication	Zagazig University	February 20 2021	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	354.27	Formula	C₁₄H₂₅Cl₂N₃O₃
CAS No.	54143-57-6	SDF	--
Smiles	O.Cl.CCN(CC)CCNC(=O)C1=CC(=C(N)C=C1OC)Cl
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 71 mg/mL ( (200.41 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 71 mg/mL

Ethanol : 71 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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