For research use only.

Catalog No.S4077

Mequinol Chemical Structure

CAS No. 150-76-5

Mequinol (4-Methoxyphenol) is a depigmentation agent.

Purity & Quality Control

Biological Activity

Description Mequinol (4-Methoxyphenol) is a depigmentation agent.
In vitro

Mequinol, diluted in the culture medium or used topically at the top of the RE, leads to a decrease in pigmentation with a diminished melanin transfer human keratinocytes and melanocytes. Mequinol induces a diminution of dopa-positive melanocyte counts. [1] Mequinol is available in the United States in 2% concentration and is commercially marketed as a prescription skin lightener in combination with 0.01% tretinoin, functioning as a penetration enhancer, and vitamin C, in the form of ascorbic acid and ascorbyl palmitate, to enhance skin lightening. Mequinol is a substrate for tyrosinase thereby acting as a competitive inhibitor in the formation of melanin precursors. [2]


Solubility (25°C)

In vitro DMSO 25 mg/mL (201.38 mM)
Water 25 mg/mL (201.38 mM)
Ethanol 25 mg/mL (201.38 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 124.14


CAS No. 150-76-5
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC=C(C=C1)O

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID