research use only

Mequinol

Name: Mequinol
Brand: Selleck Chemicals
SKU: S4077
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4077

Mequinol (4-Methoxyphenol) is a depigmentation agent. This compound is a depigmentation agent. This chemical is a depigmentation agent. This compound is a depigmentation agent.

Chemical Structure

Molecular Weight: 124.14

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Quality Control

Batch: S407701 DMSO]25 mg/mL]false]Water]25 mg/mL]false]Ethanol]25 mg/mL]false Purity: 99.84%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.84

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Solubility

In vitro
Batch:

DMSO : 25 mg/mL (201.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 25 mg/mL

Ethanol : 25 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	124.14	Formula	C₇H₈O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	150-76-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	COC1=CC=C(C=C1)O

Mechanism of Action

In vitro

Mequinol, diluted in the culture medium or used topically at the top of the RE, leads to a decrease in pigmentation with a diminished melanin transfer human keratinocytes and melanocytes. This compound induces a diminution of dopa-positive melanocyte counts. It is available in the United States in 2% concentration and is commercially marketed as a prescription skin lightener in combination with 0.01% tretinoin, functioning as a penetration enhancer, and vitamin C, in the form of ascorbic acid and ascorbyl palmitate, to enhance skin lightening. This chemical is a substrate for tyrosinase thereby acting as a competitive inhibitor in the formation of melanin precursors.

References

[1] https://pubmed.ncbi.nlm.nih.gov/9080893/
[2] https://pubmed.ncbi.nlm.nih.gov/18045355/

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