For research use only.
CAS No. 150-76-5
Mequinol (4-Methoxyphenol) is a depigmentation agent.
Purity & Quality Control
|Description||Mequinol (4-Methoxyphenol) is a depigmentation agent.|
Mequinol, diluted in the culture medium or used topically at the top of the RE, leads to a decrease in pigmentation with a diminished melanin transfer human keratinocytes and melanocytes. Mequinol induces a diminution of dopa-positive melanocyte counts.  Mequinol is available in the United States in 2% concentration and is commercially marketed as a prescription skin lightener in combination with 0.01% tretinoin, functioning as a penetration enhancer, and vitamin C, in the form of ascorbic acid and ascorbyl palmitate, to enhance skin lightening. Mequinol is a substrate for tyrosinase thereby acting as a competitive inhibitor in the formation of melanin precursors. 
|In vitro||DMSO||25 mg/mL (201.38 mM)|
|Water||25 mg/mL (201.38 mM)|
|Ethanol||25 mg/mL (201.38 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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