Name: Methyl-β-cyclodextrin (MβCD)
Brand: Selleck Chemicals
SKU: S6827
Rating: 5 (11 reviews)

Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities.

Methyl-β-cyclodextrin (MβCD) Chemical Structure

CAS: 128446-36-6

Selleck's Methyl-β-cyclodextrin (MβCD) has been cited by 11 publications

Purity & Quality Control

Batch: S682701 Purity: 98%

98

Methyl-β-cyclodextrin (MβCD) Related Products

Biological Activity

Description

Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities.

Targets

cholesterol ^[1]

lipid raft ^[1]

In vitro
In vitro	Methyl-β-cyclodextrin Inhibits SDF-1α-induced platelet aggregation and Akt phosphorylation by raft disruption.^[2]
Cell Research	Cell lines	Platelets
	Concentrations	2%
	Incubation Time	15 min
	Method	Freshly isolated human platelets are incubated with SDF-1α and centrifuged for 1 min at 3000 rpm. The resulting pellet is resuspended and boiled in Laemmli sample buffer containing phosphatase inhibitor cocktails 2 and 3. Phosphorylations of Akt (Ser473) is detected by western blotting. Platelet aggregation is measured as the optical density of PRP during aggregation using a platelet aggregometer, with the platelet-poor plasma 100% standard for change in optical density.

In Vivo
In vivo	In a Primary effusion lymphoma (PEL) xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice.^[1]

References

Chemical Information & Solubility

Molecular Weight		Formula
CAS No.	128446-36-6	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

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In vivo
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