Malotilate

For research use only.

Catalog No.S1137 Synonyms: NKK105

Malotilate Chemical Structure

Molecular Weight(MW): 288.38

Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
USD 297 In stock
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Choose Selective Lipoxygenase Inhibitors

Biological Activity

Description Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
In vitro

Malotilate at concentrations of 0.1–100 μM increases collagenase activity in a concentration-dependent manner in the multilayered cultures, but not in the monolayers. Malotilate increases the secretion of MMP-1 and MMP-3 in the wounded multilayered cultures, but not in the wounded monolayers. [1] Malotilate significantly reduces the invasion of the RLE monolayer by c-SST-2 cells. Malotilate prevents the increase in permeability of the RLE monolayer by serum starvation. Malotilate suppresses tumour metastasis by intensifying the cell-to-cell contact of endothelial cells, thus preventing tumour cells from invading vascular endothelium. [2]

In vivo Malotilate suppresses pulmonary metastasis and lung metastasis in rats. [2] Malotilate prevents increases in serum markers of type III and IV collagen synthesis as well as accumulation of the collagens, laminin and fibronectin in the liver of rats. [3] Malotilate combined with CCl4 significantly decreases hydroxyproline accumulation in the liver of rat, liver prolyl 4-hydroxylase and liver and serum galactosylhydroxylysyl glucosyltransferase activities. Malotilate is also able to prevent the development of morphological changes in the liver of rats such as focal necrosis, fatty infiltration and inflammatory changes. Malotilate also normalizes almost completely the standard liver-function tests. [4] Malotilate decreases CYP2E1 levels and increases CYP2B1 levels in hepatic microsomes of rats, while CYP1A expression is not changed. [5]

Protocol

Solubility (25°C)

In vitro DMSO 58 mg/mL (201.12 mM)
Ethanol 58 mg/mL (201.12 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 288.38
Formula

C12H16O4S2

CAS No. 59937-28-9
Storage powder
in solvent
Synonyms NKK105
Smiles CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID