MC180295

Catalog No.S8809 Synonyms: (rel)-MC180295

For research use only.

MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.

MC180295 Chemical Structure

CAS No. 2237942-08-2

Purity & Quality Control

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Biological Activity

Description MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.
Targets
CDK9-Cyclin T1 [1]
(Cell-free assay)
CDK4-Cyclin D [1]
(Cell-free assay)
CDK1-Cyclin B [1]
(Cell-free assay)
CDK5-P35 [1]
(Cell-free assay)
CDK5-P25 [1]
(Cell-free assay)
Click to View More Targets
5 nM 112 nM 138 nM 159 nM 186 nM
In vitro

MC180295 has broad anti-cancer activity in vitro[1].

In vivo

MC180295 shows promising anti-tumoral and immunosensitization activity[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Normal lung fibroblast (IMR90) and cancer cell lines (HCT116, KG-1, HL-60, SW48, MCF7, DU145 and LnCaP)
  • Concentrations: 0.1 μM
  • Incubation Time: 4 days
  • Method:

    --

Animal Research:

[1]

  • Animal Models: NSG mice
  • Dosages: 5-20mg/kg
  • Administration: IP

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 358.41
Formula

C17H18N4O3S

CAS No. 2237942-08-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC2CC1CC2NC3=NC(=C(S3)C(=O)C4=CC=CC=C4[N+](=O)[O-])N

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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