MC180295

Catalog No.S8809

MC180295 Chemical Structure

Molecular Weight(MW): 358.41

MC180295 is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.

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Biological Activity

Description MC180295 is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.
Targets
CDK9-Cyclin T1 [1]
(Cell-free assay)
CDK4-Cyclin D [1]
(Cell-free assay)
CDK1-Cyclin B [1]
(Cell-free assay)
CDK5-P35 [1]
(Cell-free assay)
CDK5-P25 [1]
(Cell-free assay)
5 nM 112 nM 138 nM 159 nM 186 nM
In vitro

MC180295 has broad anti-cancer activity in vitro[1].

In vivo

MC180295 shows promising anti-tumoral and immunosensitization activity[1].

Protocol

Cell Research:

[1]

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  • Cell lines: Normal lung fibroblast (IMR90) and cancer cell lines (HCT116, KG-1, HL-60, SW48, MCF7, DU145 and LnCaP)
  • Concentrations: 0.1 μM
  • Incubation Time: 4 days
  • Method:

    --


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: NSG mice
  • Formulation: NMP, Captisol (20% w/v), PEG-400 and normal saline (PBS) in a ratio of 1:4:4:11
  • Dosages: 5-20mg/kg
  • Administration: IP
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 72 mg/mL (200.88 mM)
Ethanol 72 mg/mL (200.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 358.41
Formula

C17H18N4O3S

CAS No. 2237942-08-2
Storage powder
in solvent
Synonyms N/A

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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CDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID