Home Protein Tyrosine Kinase c-Kit inhibitor Masitinib mesylate

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Masitinib mesylate c-Kit inhibitor

Cat.No.E0814

Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit with IC50 of 200 nM for human recombinant c-Kit, also inhibits PDGFRα/β with IC50s of 540/800 nM, Lyn with IC50 of 510 nM for LynB, and, to a lesser extent, FGFR3 and FAK.
Masitinib mesylate c-Kit inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 594.75

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Quality Control

Batch: E081401 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]Insoluble]false Purity: 99.99%
99.99

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (168.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 594.75 Formula

C28H30N6OS.CH4O3S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1048007-93-7 Download SDF Storage of Stock Solutions

Synonyms AB-1010 mesylate Smiles CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC(=CS4)C5=CN=CC=C5.C[S](O)(=O)=O

Mechanism of Action

Targets/IC50/Ki
FGFR3
FAK
human recombinant c-Kit
200 nM
LynB
510 nM
PDGFRα
540 nM
PDGFRβ
800 nM
References

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