Home Neuronal Signaling Dopamine Receptor antagonist Metoclopramide

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Metoclopramide Dopamine Receptor antagonist

Cat.No.S5862

Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting.
Metoclopramide Dopamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 299.80

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S586201 DMSO]60 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.95%
99.95

Chemical Information, Storage & Stability

Molecular Weight 299.80 Formula

C14H22ClN3O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 364-62-5 -- Storage of Stock Solutions

Synonyms N/A Smiles CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl

Solubility

In vitro
Batch:

DMSO : 60 mg/mL (200.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Dopamine receptor [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Recruiting
Post-operative Nausea and Vomiting
Milton S. Hershey Medical Center
 February 1 2024 Phase 2
NCT06297954 Recruiting
Upper Gastrointestinal Bleeding
Universidad Autonoma de Nuevo Leon
 March 16 2023 Phase 3
NCT05832151 Recruiting
Diabetic Gastroparesis
CinDome Pharma Inc.
 March 27 2023 Phase 2
NCT05008926 Recruiting
Brain Injuries
University Hospital Brest
 March 15 2022 Phase 3
NCT04748133 Unknown status
Treatment Complication
Zagazig University
 February 20 2021 Not Applicable

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