For research use only.

Catalog No.S8236 Synonyms: L-663,536

5 publications

MK-886 Chemical Structure

CAS No. 118414-82-7

MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.

Selleck's MK-886 has been cited by 5 publications

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  • HepG2 cells were subjected to the PPARα antagonist MK886 (20 μM) or the PPARγ antagonist T0070907 (20 μM) for 2 h, followed by N15 (100 μM) treatment for an additional 12h.

    Eur J Pharmacol, 2018, 826:1-8. MK-886 purchased from Selleck.

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Biological Activity

Description MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
5-lipoxygenase-activating protein (FLAP) [1] PPARα [3] COX-1 [1] COX-2 [1]
8 μM 58 μM
In vitro

MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the 5-lipoxygenase (EC pathway in cellular or animal models of inflammation, allergy, cancer, and cardiovascular disease. MK-886 inhibits isolated COX-1 (IC50=8 μM) and blocks the formation of the COX-1-derived products 12(S)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid (12-HHT) and thromboxane B2 in washed human platelets in response to collagen as well as from exogenous arachidonic acid (IC50=13–15 μM).Isolated COX-2 was less affected (IC50=58 μM), and in A549 cells, MK-886 (33 μM) failed to suppress COX-2-dependent 6-ketoprostaglandin (PG)F1α formation. MK-886 (10 μM) inhibits COX-1-mediated platelet aggregation induced by collagen or arachidonic acid whereas thrombin- or U-46619-induced (COX-independent) aggregation is not affected[1].

In vivo Repeated daily i.p. injections of MK-886 results in increased GluR1 phosphorylation in brain samples obtained from the prefrontal cortex. In contrast, a single injection of MK-886 does not alter cortical GluR1 phosphorylation[2].


Cell Research:


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  • Cell lines:  A549 cells
  • Concentrations: 33 μM
  • Incubation Time: 15 min
  • Method:

    IL-1β-stimulated A549 cells (5×106/ml) are pre-incubated with MK-886 (MK, 33 μM), indomethacin (Indo, 10 μM), celecoxib (Cele, 5 μM) or vehicle (DMSO) for 15 min prior to the addition of 30 μM arachidonic acid. After 15 min at 37 °C, the amount of released 6-keto PGF1α was assessed by ELISA as described in the Materials and methods section.

    (Only for Reference)
Animal Research:


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  • Animal Models: Male C57BL/6J mice
  • Dosages: 3 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 94 mg/mL (199.11 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 472.08


CAS No. 118414-82-7
Storage powder
in solvent
Synonyms L-663,536
Smiles CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID