Home Epigenetics Sirtuin activator MDL-800 For research use only.

MDL-800

MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM.

MDL-800 Chemical Structure

MDL-800 Chemical Structure

CAS: 2275619-53-7

Purity & Quality Control

Batch: E126701 DMSO] 100 mg/mL] false] Ethanol] 13 mg/mL] false] Water] Insoluble] false Purity: 99.06%
99.06

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Biological Activity

Description MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM.
Targets
sirtuin 6 [1]

Chemical Information & Solubility

Molecular Weight 626.30 Formula

C21H16BrCl2FN2O6S2
CAS No. 2275619-53-7 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (159.66 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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