Catalog No.S1987 Synonyms: SCH-32088
Molecular Weight(MW): 521.43
Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
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Choose Selective Glucocorticoid Receptor Inhibitors
|Description||Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.|
Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response. 
|In vivo||Mometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats.  Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule.  Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect.  Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice. |
-  Magari M, et al. Immunopharmacol Immunotoxicol,?006, 28(3), 491-500.
-  Tsumuro T, et al. Eur J Pharmacol,?005, 524(1-3), 155-158.
-  Wyss D, et al. Br J Pharmacol,?007, 152(1), 83-90.
|In vitro||DMSO||6 mg/mL (11.5 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02967731||Completed||Drug: 480 Mometasone Furoate Sinus Drug Depot||Chronic Sinusitis||480 Biomedical Inc.|480 Biomedical||June 6 2017||Phase 1|
|NCT01894503||Completed||Drug: S8 Sinus Implant (mometasone furoate 1350 mcg)||Chronic Sinusitis||Intersect ENT||June 2013||Phase 2|
|NCT01702103||Unknown status||Drug: Mometasone furoate||Nasal Obstruction|Sneezing|Itching||PH&T S.p.A.||October 2012||Phase 3|
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