Mometasone furoate

For research use only.

Catalog No.S1987 Synonyms: SCH-32088

Mometasone furoate Chemical Structure

CAS No. 83919-23-7

Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.

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Biological Activity

Description Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
Glucocorticoid receptor [1]
In vitro

Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response. [1]

In vivo Mometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats. [2] Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule. [3] Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect. [4] Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice. [5]


Solubility (25°C)

In vitro DMSO 6 mg/mL (11.5 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.43


CAS No. 83919-23-7
Storage powder
in solvent
Synonyms SCH-32088
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04589663 Recruiting Drug: Mometasone furoate|Drug: QMF149 Asthma Novartis Pharmaceuticals|Novartis June 7 2021 Phase 2
NCT02967731 Completed Drug: 480 Mometasone Furoate Sinus Drug Depot Chronic Sinusitis Lyra Therapeutics June 6 2017 Phase 1
NCT01894503 Completed Drug: S8 Sinus Implant (mometasone furoate 1350 mcg) Chronic Sinusitis Intersect ENT June 2013 Phase 2
NCT01702103 Unknown status Drug: Mometasone furoate Nasal Obstruction|Sneezing|Itching PH&T S.p.A. October 2012 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID