For research use only.
Catalog No.S1987 Synonyms: SCH-32088
CAS No. 83919-23-7
Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
Purity & Quality Control
Choose Selective Glucocorticoid Receptor Inhibitors
|Description||Mometasone Furoate is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.|
Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response. 
|In vivo||Mometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats.  Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule.  Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect.  Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice. |
-  Magari M, et al. Immunopharmacol Immunotoxicol,?006, 28(3), 491-500.
-  Tsumuro T, et al. Eur J Pharmacol,?005, 524(1-3), 155-158.
-  Wyss D, et al. Br J Pharmacol,?007, 152(1), 83-90.
|In vitro||DMSO||6 mg/mL (11.5 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02967731||Completed||Drug: 480 Mometasone Furoate Sinus Drug Depot||Chronic Sinusitis||480 Biomedical Inc.|480 Biomedical||June 6 2017||Phase 1|
|NCT01894503||Completed||Drug: S8 Sinus Implant (mometasone furoate 1350 mcg)||Chronic Sinusitis||Intersect ENT||June 2013||Phase 2|
|NCT01702103||Unknown status||Drug: Mometasone furoate||Nasal Obstruction|Sneezing|Itching||PH&T S.p.A.||October 2012||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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