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7-Methoxyisoflavone AMPK activator

Name: 7-Methoxyisoflavone
Brand: Selleck Chemicals
SKU: S1323
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S1323

7-Methoxyisoflavone (MIF) is a potent activator of adenosine monophosphate-activated protein kinase (AMPK).

Chemical Structure

Molecular Weight: 252.26

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S132301 DMSO]30 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.80%

99.80

Related Targets	PI3K Akt mTOR GSK-3 ATM/ATR DNA-PK PDPK1 PTEN PP2A PDK PI4K PIKfyve MELK
Related Products	Dorsomorphin Dihydrochloride Dorsomorphin AICAR (Acadesine) A-769662 GSK621 WZ4003 ex229 (compound 991) Phenformin HCl HTH-01-015 BAY-3827 O-304 MK-3903 BAM 15 Danthron

Chemical Information, Storage & Stability

Molecular Weight	252.26	Formula	C₁₆H₁₂O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1621-56-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	MIF			Smiles	COC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=CC=C3

Solubility

In vitro
Batch:

DMSO : 30 mg/mL ( (118.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	AMPK ^[1]
References	https://link.springer.com/article/10.1007/s13765-016-0149-8

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06137716	Completed	Robotic Exoskeleton\|Post-acute Covid-19 Syndrome\|Rehabilitation Outcome\|Physical And Rehabilitation Medicine	University of Valladolid\|Centro Hospitalario Padre Benito Menni	July 1 2022	Not Applicable
NCT05175638	Unknown status	COVID-19 Pandemic	Assiut University	February 2022	--
NCT04315818	Unknown status	Rheumatoid Arthritis	Assiut University	March 2021	--

Tech Support

Handling Instructions

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