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Molsidomine

Name: Molsidomine
Brand: Selleck Chemicals
SKU: S4664
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S4664

Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. This compound is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

Chemical Structure

Molecular Weight: 242.23

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: 99.92%

99.92

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Chemical Information, Storage & Stability

Molecular Weight	242.23	Formula	C₉H₁₄N₄O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	25717-80-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SIN-10, Corvaton, Morsydomine			Smiles	CCOC(=NC1=C[N+](=NO1)N2CCOCC2)[O-]

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (202.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 24 mg/mL

Ethanol : 24 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vivo

Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by this compound. This chemical decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by it. Stroke volume and cardiac output fall after this agent. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart^[1].

References

[1] http://link.springer.com/article/10.1007/BF00506260

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