MT-802

Catalog No.S6966

For research use only.

MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).

MT-802 Chemical Structure

CAS No. 2231744-29-7

Purity & Quality Control

Choose Selective BTK Inhibitors

Biological Activity

Description MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).
Targets
BTK [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(126.93 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 787.82
Formula

C41H41N9O8

CAS No. 2231744-29-7
Storage 3 years -20°C powder
2 years -80°C in solvent

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