Micafungin (FK 463) Sodium

For research use only.

Catalog No.S4287 Synonyms: Mycamine Sodium

11 publications

Micafungin (FK 463) Sodium Chemical Structure

CAS No. 208538-73-2

Micafungin Sodium (FK463, Mycamine) is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.

Selleck's Micafungin (FK 463) Sodium has been cited by 11 publications

3 Customer Reviews

  • Effect of Micafungin on erythrocyte forward scatter. A. Original histogram of forward scatter of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presense of 25 µg/ml Micafungin. B. Arithmetic means ± SEM (n = 14) of the erythrocyte forward scatter (FSC) following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). C. Arithmetic means ± SEM (n = 14) of the percentage of erythrocytes with forward scatter(FSC) <200 following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). D. Arithmetic means ± SEM (n = 14) of the percentage of erythrocytes with forward scatter (FSC) >800 following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). ***(p<0.001) indicates significant difference from the absence of Micafungin (ANOVA).

    Cell Physiol Biochem, 2016, 584-95. Micafungin (FK 463) Sodium purchased from Selleck.

    Micafungin potently inhibits EV71 proliferation in LLC-MK2 Derivative cells. LLC-MK2 Derivative cells were infected with EV71 (100 CCID50) and immediately treated with increasing concentrations of micafungin. Twenty hours post-infection, dsRNAs were stained by using specific antibody and visualized by FITC-conjugated secondary antibody (green). Nuclear DNA was also visualized by DAPI staining (blue).

    Virol J, 2016, 13(1):99.. Micafungin (FK 463) Sodium purchased from Selleck.

  • Cell-to-cell transmission levels of CHIKV under micafungin treatment.

    Antiviral Res, 2018, 159:134-142. Micafungin (FK 463) Sodium purchased from Selleck.

Purity & Quality Control

Choose Selective Fungal Inhibitors

Biological Activity

Description Micafungin Sodium (FK463, Mycamine) is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.
In vitro

Micafungin is an antifungal agent that does not inhibit bacteria. Although micafungin does not inhibit the bacteria directly, it does promote the survival of G. mellonella[1]. Micafungin inhibits biofilm formation by impeding 1,3-β-D-glucan synthesis in Candida albicans[2].

Protocol

Cell Research:

[2]

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  • Cell lines: bactrial cells
  • Concentrations: 10 mg/ml
  • Incubation Time: --
  • Method:

    --


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: CD1 mice
  • Dosages: 5 mg/kg/day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (77.38 mM)
Ethanol '''-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1292.26
Formula

C56H70N9NaO23S

CAS No. 208538-73-2
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms Mycamine Sodium
Smiles CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC(=C(C=C7)O)OS(=O)(=O)[O-])O)O)C(CC(=O)N)O)C)O)O)O.[Na+]

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID