ML167

Catalog No.S7509 Synonyms: CID 44968231

For research use only.

ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.

ML167 Chemical Structure

CAS No. 1285702-20-6

Selleck's ML167 has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
Targets
CLK4 [1] CLK1 [1] CLK2 [1] Dyrk1B [1]
136 nM 1522 nM 1648 nM 4420 nM
In vitro

ML167, as a probe of Clk4, shows high cell permeability in a Caco-2 assay. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 67 mg/mL
(199.78 mM)
Ethanol 13 mg/mL warmed
(38.76 mM)
Water Insoluble

Chemical Information

Molecular Weight 335.36
Formula

C19H17N3O3

CAS No. 1285702-20-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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