Mercaptopurine (6-MP)

For research use only.

Catalog No.S1305

2 publications

Mercaptopurine (6-MP) Chemical Structure

Molecular Weight(MW): 152.18

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

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10mM (1mL in DMSO) USD 100 In stock
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USD 170 In stock
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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Targets
PRPP Amidotransferase [2]
In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 leukemia cells MmK2SpVv[3Srb36gZZN{[Xl? M{TuUGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDvckBufWy2aXTyeYcuemW|aYP0ZY51KExzMkGwJIxmfWunbXnhJINmdGy|LDDJR|UxRTBwMEK0JO69VQ>? MXyxPVA3OTB5
MT4 cells NFi0UplRem:uaX\ldoF1cW:wIHHzd4F6 NYXiZZFESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWFQh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOSEQvF2= NW\menU1OTd{NUS2Olk>
human CCRF-CEM cells MVHQdo9tcW[ncnH0bY9vKGG|c3H5 NWLUfHBUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNUOHTTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MTFOwG0> MXWxO|I2PDZ4OR?=
human CCRF-SB cells NHnBfGJRem:uaX\ldoF1cW:wIHHzd4F6 NXO1SFZKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNVOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1zIN88US=> M4n3cFE4OjV2Nk[5
human SK-MEL-28 cells Mke4VJJwdGmoZYLheIlwdiCjc4PhfS=> NFvYZ2lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMW1GVC1{ODDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MUWg{txO MUGxO|I2PDZ4OR?=
human MCF7 cells MYnQdo9tcW[ncnH0bY9vKGG|c3H5 Mny2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3ME2zJO69VQ>? M3jRZVE4OjV2Nk[5
human HepG2 cells MYPQdo9tcW[ncnH0bY9vKGG|c3H5 M2XqZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVgh|ryP NXf0eGQ3OTd{NUS2Olk>
human DU145 cells MnLzVJJwdGmoZYLheIlwdiCjc4PhfS=> NVXlbFBtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OiEQvF2= NGDybGkyPzJ3NE[2PS=>
mouse J774.A1 cells MVzQdo9tcW[ncnH0bY9vKGG|c3H5 NFvCSmY{KGSjeYO= NHrwRpZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFq3O|QvSTFiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCClb372[ZJ{cW:wIHHzd4F6NCCLQ{WwQVAvODB|IN88US=> NID3VZUyPjZ2M{C0NC=>
HEK293 cells NVfWbVV5WHKxbHnm[ZJifGmxbjDhd5NigQ>? MUKzJIRigXN? MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFjFT|I6OyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGOxbo\ldpNqd25iYYPzZZktKEmFNUC9NE4xODdizszN NHvSbGwyPjZ2M{C0NC=>
mouse J774 cells NYjB[4xUWHKxbHnm[ZJifGmxbjDhd5NigQ>? M2LiZ|czKGh? MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEp5N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxRTBwMECzJO69VQ>? NX\v[lhzOTB5NUe3NFg>
human PBMC MlnQSpVv[3Srb36gZZN{[Xl? MknoOEBl[Xm| NX\lb5dtUW6qaXLpeIlwdiCxZjDUJINmdGxibXn0c4dmdi2rbnT1Z4VlKGKuYYP0c4dmdmW|aYOgbY4hcHWvYX6gVGJOSyCjZoTldkA1KGSjeYOsJGlEPTB;MD6xOFk2KM7:TR?= M3fOWlE5PDZ5MEC3
HeLa cells MlzSR5l1d3SxeHnjbZR6KGG|c3H5 M17EWFQ5KGh? MnX3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BifCCuYXegdIhie2Vib3[g[5Jwf3SqIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oi57IN88US=> MmrYNVk4OTF7OEe=
A549 cells MoLDR5l1d3SxeHnjbZR6KGG|c3H5 MVy0PEBp M1S2ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XRibHHnJJBp[XOnIH;mJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTR5IN88US=> NF\vSIYyQTdzMUm4Oy=>
MCF7 cells MYXDfZRwfG:6aXPpeJkh[XO|YYm= M1jseFQ5KGh? M4LBb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XRibHHnJJBp[XOnIH;mJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTFwNDFOwG0> M2PMZVE6PzFzOUi3
MT4 cells M3TYb2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHz6d4Y6PiCq MnfWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXQ1KGOnbHzzJIlv\mWldHXkJJdqfGhiSGTMWk0yKGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEOFNUC9NE4yKM7:TR?= M4LFXVIyPzRzMUOw
CCRF-CEM cells MXnQdo9tcW[ncnH0bY9vKGG|c3H5 MmryPVYhcA>? MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tR2VOKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;MTFOwG0> MVmyNVc1OTF|MB?=
WIL2-NS cells MYrQdo9tcW[ncnH0bY9vKGG|c3H5 MnzTPVYhcA>? NWPPeVZ3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDXTWwzNU6VIHPlcIx{KGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEOFNUC9N{DPxE1? NYW0TFN4OjF5NEGxN|A>
CCRF-SB cells NHXPcVZRem:uaX\ldoF1cW:wIHHzd4F6 M3TUNlk3KGh? MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tV2Ih[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygR2M2OD1zLkGg{txO NFzzNXozOTd2MUGzNC=>
human DU145 cells NEiyemxRem:uaX\ldoF1cW:wIHHzd4F6 NGTLSXg6PiCq NUf6fpM6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBESzVyPUKg{txO NFW0XGYzOTd2MUGzNC=>
human HepG2 cells MUTQdo9tcW[ncnH0bY9vKGG|c3H5 M3v5Olk3KGh? NY\xZpdPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBESzVyPUig{txO M1HHdFIyPzRzMUOw
MCF7 cells MWfQdo9tcW[ncnH0bY9vKGG|c3H5 NFnXRXU6PiCq M1W4ZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTNwMjFOwG0> M3LwcVIyPzRzMUOw
SK-MEL-28 cells M{LUW3Bzd2yrZnXyZZRqd25iYYPzZZk> M37hXFk3KGh? MmLRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSz3NSWwuOjhiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhS0N3ME2xOUDPxE1? MlLmNlE4PDFzM{C=
MCF7 cells MX\DfZRwfG:6aXPpeJkh[XO|YYm= NUD4U3NoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyxiSVO1NF0zNjd7IN88US=> NFTVe4UzOzRzMUmxOS=>
mouse S49 cells M4jWSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIHqWG04OiCq MVzDfZRwfG:6aXPpeJkh[WejaX7zeEB4cWymIIT5dIUhdW:3c3WgV|Q6KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUB1enmyYX6gZox2\SCneHPseZNqd25iYYPzZZktKEWFNUC9PEDPxE1? NI\B[nczOjF4NUi=
Colo-357 cells M3K0WGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDc4xwNTN3NzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF03NjF{IN88US=> M4D0W|IxQTNyMUKz
Aspc-1 cells MofmR5l1d3SxeHnjbZR6KGG|c3H5 M2DtO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{eGNvMTDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF0zNjR3IN88US=> M3fuOFIxQTNyMUKz
A549 cells NH\0SIlEgXSxdH;4bYNqfHliYYPzZZk> NXewTlhwPDhiaB?= M4rNOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20O{DPxE1? MX2yNlcxPTByMR?=
MCF7 cells NYrCUXhZS3m2b4TvfIlkcXS7IHHzd4F6 NEnuOIo1QCCq MknYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGuOEDPxE1? NH\1OZczOjdyNUCwNS=>
Patu-02 cells MYPDfZRwfG:6aXPpeJkh[XO|YYm= Ml;DR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS1yMjDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF06NjZ7IN88US=> M{LGcVIxQTNyMUKz
Patu-T cells NYS2RYZLS3m2b4TvfIlkcXS7IHHzd4F6 Mk\qR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVQvODlizszN M2nMUFIxQTNyMUKz
Patu-S cells NV34b4hzS3m2b4TvfIlkcXS7IHHzd4F6 Mn7CR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS2VIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVEyNjB5IN88US=> MWOyNFk{ODF{Mx?=
T3M4 cells NUPIXpp[S3m2b4TvfIlkcXS7IHHzd4F6 MkOxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFNOPCClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3ME2yMlY{KM7:TR?= NV\sXIVTOjB7M{CxNlM>
human PANC1 cells MXTDfZRwfG:6aXPpeJkh[XO|YYm= NVOxZVExS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVA:Pi5|OTFOwG0> NF3u[GwzODl|MEGyNy=>
human DAN-G cells MnzQR5l1d3SxeHnjbZR6KGG|c3H5 NGG4eVVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFSU5vRzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF01NjB4IN88US=> NUfMPGtIOjB7M{CxNlM>
HeLa cells NHLoV3hEgXSxdH;4bYNqfHliYYPzZZk> M{fWbVQ5KGh? MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Mj65JO69VQ>? M13DcVIzPzB3MECx
WEHI164 cells NITQd5pRem:uaX\ldoF1cW:wIHHzd4F6 NHX3XXU{KGSjeYO= NYf4OpNGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDXSWhKOTZ2IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiY3;ueoVze2mxbjDhd5NigSxiSVO1NF0xNjBzNTFOwG0> MVOxOlY1OzB2MB?=
WIL-2NS cells MmHZVJJwdGmoZYLheIlwdiCjc4PhfS=> MnPDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZSVytNm5UKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{KM7:TR?= NWLFZ5ZFOTd{NUS2Olk>
WEHI164 cells MWjQdo9tcW[ncnH0bY9vKGG|c3H5 NULVW4Y{PzJiaB?= MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKFeHSFmxOlQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIHPlcIwh\3Kxd4ToJIFnfGW{IEeyJIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyPUCuNFE4KM7:TR?= MUCxNFc2PzdyOB?=

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Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (197.13 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 152.18
Formula

C5H4N4S

CAS No. 50-44-2
Storage powder
in solvent
Synonyms N/A
Smiles S=C1N=CNC2=C1[NH]C=N2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022747 Unknown status Drug: Allopurinol|Drug: Standard treatment Lymphoblastic Leukemia Acute Childhood Vastra Gotaland Region January 2017 Phase 2
NCT04304950 Recruiting Drug: Evening Group|Drug: Morning Group Inflammatory Bowel Diseases Rush University Medical Center April 25 2016 Phase 4
NCT03920813 Enrolling by invitation Drug: Mercaptopurine Acute Lymphoblastic Leukemia Shandong University January 2015 Phase 4

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID