Mercaptopurine (6-MP)

Catalog No.S1305

Mercaptopurine (6-MP) Chemical Structure

Molecular Weight(MW): 152.18

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Size Price Stock Quantity  
In DMSO USD 100 In stock
USD 97 In stock
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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Targets
PRPP Amidotransferase [2]
In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 leukemia cells MmPuSpVv[3Srb36gZZN{[Xl? MmHHTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIH;uJI12dHSrZIL1[{1z\XOrc4ThcpQhVDF{MUCgcIV2c2WvaXGgZ4VtdHNuIFnDOVA:OC5yMkSg{txO M3rZRlE6ODZzMEe=
MT4 cells M1:zOHBzd2yrZnXyZZRqd25iYYPzZZk> MkjpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPVESgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNUDPxE1? M3S5fFE4OjV2Nk[5
human CCRF-CEM cells MlPUVJJwdGmoZYLheIlwdiCjc4PhfS=> M1\HWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1PSSk1ETU1iY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTFizszN MU[xO|I2PDZ4OR?=
human CCRF-SB cells NHvoXJJRem:uaX\ldoF1cW:wIHHzd4F6 NHW3SZRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuW0JiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTFizszN MnPsNVczPTR4Nkm=
human SK-MEL-28 cells MVjQdo9tcW[ncnH0bY9vKGG|c3H5 Mm[4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSz3NSWwuOjhiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTF3IN88US=> MYqxO|I2PDZ4OR?=
human MCF7 cells M3e5VnBzd2yrZnXyZZRqd25iYYPzZZk> M2fWZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9N{DPxE1? Ml3zNVczPTR4Nkm=
human HepG2 cells MVjQdo9tcW[ncnH0bY9vKGG|c3H5 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3ME24JO69VQ>? NWnzXlJSOTd{NUS2Olk>
human DU145 cells MV7Qdo9tcW[ncnH0bY9vKGG|c3H5 NVPXSXVtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OiEQvF2= MVixO|I2PDZ4OR?=
mouse J774.A1 cells MX;Qdo9tcW[ncnH0bY9vKGG|c3H5 NVTQW4tMOyCmYYnz MnvrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCMN{e0MmEyKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[2:wdnXyd4lwdiCjc4PhfUwhUUN3ME2wMlAxOyEQvF2= NV61OohIOTZ4NEOwOFA>
HEK293 cells MkmzVJJwdGmoZYLheIlwdiCjc4PhfS=> NFnRNpQ{KGSjeYO= MoD1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDISWszQTNiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCClb372[ZJ{cW:wIHHzd4F6NCCLQ{WwQVAvODB5IN88US=> NX\3fGY6OTZ4NEOwOFA>
mouse J774 cells M2CzenBzd2yrZnXyZZRqd25iYYPzZZk> MVq3NkBp M2\MVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViSke3OEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiY3XscEBoem:5dHigZYZ1\XJiN{KgbJJ{KGK7IF3UWEBu\XSqb3SsJGlEPTB;MD6wNFMh|ryP Mn7ONVA4PTd5MEi=
human PBMC MnK4SpVv[3Srb36gZZN{[Xl? MVO0JIRigXN? NYDD[YN5UW6qaXLpeIlwdiCxZjDUJINmdGxibXn0c4dmdi2rbnT1Z4VlKGKuYYP0c4dmdmW|aYOgbY4hcHWvYX6gVGJOSyCjZoTldkA1KGSjeYOsJGlEPTB;MD6xOFk2KM7:TR?= NGLKXoQyQDR4N{CwOy=>
HeLa cells M3HrdmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVK0PEBp MkTHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BifCCuYXegdIhie2Vib3[g[5Jwf3SqIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oi57IN88US=> MX:xPVcyOTl6Nx?=
A549 cells M1rB[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVi0PEBp NEnUbVREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG2IHzh[{BxcGG|ZTDv[kBoem:5dHigZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12NzFOwG0> M4fZSlE6PzFzOUi3
MCF7 cells NVjaTJI6S3m2b4TvfIlkcXS7IHHzd4F6 MXi0PEBp NHTabY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG2IHzh[{BxcGG|ZTDv[kBoem:5dHigZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zLkSg{txO NUjiS4FHOTl5MUG5PFc>
MT4 cells NIX3cZBEgXSxdH;4bYNqfHliYYPzZZk> NHTIbnY6PiCq NELWb4pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXDRiY3XscJMhcW6oZXP0[YQhf2m2aDDIWGxXNTFiYX\0[ZIhQTZiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NF0xNjFizszN NFjo[m0zOTd2MUGzNC=>
CCRF-CEM cells Mom1VJJwdGmoZYLheIlwdiCjc4PhfS=> NYfDdnBLQTZiaB?= M{jmdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1PSSk1ETU1iY3XscJMh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhS0N3ME2xJO69VQ>? NIDMdG8zOTd2MUGzNC=>
WIL2-NS cells NILRbIpRem:uaX\ldoF1cW:wIHHzd4F6 MVe5OkBp NYjlN5ZrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDXTWwzNU6VIHPlcIx{KGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEOFNUC9N{DPxE1? NHjOfpQzOTd2MUGzNC=>
CCRF-SB cells NILMPHZRem:uaX\ldoF1cW:wIHHzd4F6 MX65OkBp MlnFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFQ2LGMXNDKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;MT6xJO69VQ>? NYG0WFBNOjF5NEGxN|A>
human DU145 cells MXfQdo9tcW[ncnH0bY9vKGG|c3H5 MVu5OkBp NFPG[FZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;MjFOwG0> MV:yNVc1OTF|MB?=
human HepG2 cells NF[wTmVRem:uaX\ldoF1cW:wIHHzd4F6 M1vlOVk3KGh? MnW4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRThizszN MUSyNVc1OTF|MB?=
MCF7 cells NX7FfIR5WHKxbHnm[ZJifGmxbjDhd5NigQ>? NIXjflg6PiCq M2TibmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTNwMjFOwG0> NFz4bmQzOTd2MUGzNC=>
SK-MEL-28 cells M4rKV3Bzd2yrZnXyZZRqd25iYYPzZZk> NWT2UpAxQTZiaB?= NVr6fHRoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NF0yPSEQvF2= M2Hv[|IyPzRzMUOw
MCF7 cells M1nsOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF63Om9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{NCCLQ{WwQVIvPzlizszN NHrqO4szOzRzMUmxOS=>
mouse S49 cells NFvmU4lEgXSxdH;4bYNqfHliYYPzZZk> MnH2O|IhcA>? MnfhR5l1d3SxeHnjbZR6KGGpYXnud5Qhf2muZDD0fZBmKG2xdYPlJHM1QSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhfHK7cHHuJIJtfWViZYjjcJV{cW:wIHHzd4F6NCCHQ{WwQVgh|ryP NXrpUnc{OjJzNkW4
Colo-357 cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= M4DXXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNwdG9vM{W3JINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxRTZwMUKg{txO NUSxZXlnOjB7M{CxNlM>
Aspc-1 cells MlLaR5l1d3SxeHnjbZR6KGG|c3H5 MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBd5BkNTFiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUC9Nk41PSEQvF2= M{ez[|IxQTNyMUKz
A549 cells NYXOVG01S3m2b4TvfIlkcXS7IHHzd4F6 NGLHeVY1QCCq MonaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUS3JO69VQ>? MknwNlI4ODVyMEG=
MCF7 cells MYXDfZRwfG:6aXPpeJkh[XO|YYm= Mkj2OFghcA>? MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT60JO69VQ>? MlXsNlI4ODVyMEG=
Patu-02 cells NW\4e2lWS3m2b4TvfIlkcXS7IHHzd4F6 MoPjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS1yMjDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF06NjZ7IN88US=> MX[yNFk{ODF{Mx?=
Patu-T cells M{HsUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQZZR2NVRiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUC9OE4xQSEQvF2= NWT3fGhwOjB7M{CxNlM>
Patu-S cells NHmzXJdEgXSxdH;4bYNqfHliYYPzZZk> MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQZZR2NVNiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUC9NVEvODdizszN M4KxUVIxQTNyMUKz
T3M4 cells M4KwVmN6fG:2b4jpZ4l1gSCjc4PhfS=> MknMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFNOPCClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3ME2yMlY{KM7:TR?= MWSyNFk{ODF{Mx?=
human PANC1 cells M2r0dWN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml;4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUC9Ok4{QSEQvF2= NIfSZ4gzODl|MEGyNy=>
human DAN-G cells Mn;hR5l1d3SxeHnjbZR6KGG|c3H5 NIrrcoNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFSU5vRzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF01NjB4IN88US=> MmTUNlA6OzBzMkO=
HeLa cells NVjUW|dOS3m2b4TvfIlkcXS7IHHzd4F6 NVfTVoJpPDhiaB?= NInheoFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Nk46KM7:TR?= MW[yNlcxPTByMR?=
WEHI164 cells MWXQdo9tcW[ncnH0bY9vKGG|c3H5 NHnQTHI{KGSjeYO= NED1W3JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGfFTGkyPjRiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCClb372[ZJ{cW:wIHHzd4F6NCCLQ{WwQVAvODF3IN88US=> NULzdop{OTZ4NEOwOFA>
WIL-2NS cells MUfQdo9tcW[ncnH0bY9vKGG|c3H5 M1H0emFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iV1nMMVJPWyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OyEQvF2= M33JO|E4OjV2Nk[5
WEHI164 cells Mo\3VJJwdGmoZYLheIlwdiCjc4PhfS=> NFL3XWM4OiCq NFnqfGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGfFTGkyPjRiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czDifUBOXFRibXX0bI9lNCCLQ{WwQVAvODF5IN88US=> NF36XnIyODd3N{ewPC=>

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Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (197.13 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 152.18
Formula

C5H4N4S

CAS No. 50-44-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022747 Unknown status Drug: Allopurinol|Drug: Standard treatment Lymphoblastic Leukemia Acute Childhood Vastra Gotaland Region January 2017 Phase 2
NCT03920813 Enrolling by invitation Drug: Mercaptopurine Acute Lymphoblastic Leukemia Shandong University January 2015 Phase 4
NCT02046694 Recruiting Drug: Allopurinol Acute Lymphoblastic Leukemia (ALL) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins January 2014 Early Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID