Mercaptopurine (6-MP)

For research use only.

Catalog No.S1305

6 publications

Mercaptopurine (6-MP) Chemical Structure

CAS No. 50-44-2

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

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10mM (1mL in DMSO) USD 100 In stock
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Selleck's Mercaptopurine (6-MP) has been cited by 6 publications

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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Targets
PRPP Amidotransferase [2]
In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 leukemia cells NXTY[nloTnWwY4Tpc44h[XO|YYm= MV3Jcohq[mm2b4L5JINwdmOnboTyZZRqd25ib36gcZVtfGmmcoXnMZJme2m|dHHueEBNOTJzMDDs[ZVs\W2rYTDj[YxteyxiSVO1NF0xNjB{NDFOwG0> NGnBZYMyQTB4MUC3
MT4 cells NFz6c5VRem:uaX\ldoF1cW:wIHHzd4F6 M3;3S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTWS0JINmdGy|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlEh|ryP M{PjRlE4OjV2Nk[5
human CCRF-CEM cells NFPudZZRem:uaX\ldoF1cW:wIHHzd4F6 NFjVU3dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuS0WPIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1zIN88US=> NHLSTokyPzJ3NE[2PS=>
human CCRF-SB cells NYH0UZhLWHKxbHnm[ZJifGmxbjDhd5NigQ>? MnrNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFQ2LGMXNDKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0yKM7:TR?= MX[xO|I2PDZ4OR?=
human SK-MEL-28 cells NUHJRYd5WHKxbHnm[ZJifGmxbjDhd5NigQ>? MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLV3FUE0zQCClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OTVizszN M{m0[lE4OjV2Nk[5
human MCF7 cells NUXGeWUzWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1vFXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9N{DPxE1? MWKxO|I2PDZ4OR?=
human HepG2 cells NUXuU5RIWHKxbHnm[ZJifGmxbjDhd5NigQ>? MkDaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9PEDPxE1? Mkf2NVczPTR4Nkm=
human DU145 cells MWjQdo9tcW[ncnH0bY9vKGG|c3H5 M{TDcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIh|ryP NEXJT3MyPzJ3NE[2PS=>
mouse J774.A1 cells NWjiWnlwWHKxbHnm[ZJifGmxbjDhd5NigQ>? NWLXZ|B4OyCmYYnz NFXadYRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFq3O|QvSTFiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCClb372[ZJ{cW:wIHHzd4F6NCCLQ{WwQVAvODB|IN88US=> M3nre|E3PjR|MESw
HEK293 cells MXnQdo9tcW[ncnH0bY9vKGG|c3H5 NWPk[pYxOyCmYYnz M4PGNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTGVMOjl|IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiY3;ueoVze2mxbjDhd5NigSxiSVO1NF0xNjByNzFOwG0> M1qyPVE3PjR|MESw
mouse J774 cells MkLQVJJwdGmoZYLheIlwdiCjc4PhfS=> M3r1PVczKGh? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEp5N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxRTBwMECzJO69VQ>? NHfpXo0yODd3N{ewPC=>
human PBMC MX;GeY5kfGmxbjDhd5NigQ>? MkHYOEBl[Xm| MX\Jcohq[mm2aX;uJI9nKFRiY3XscEBucXSxZ3XuMYlv\HWlZXSgZoxie3SxZ3Xu[ZNqeyCrbjDoeY1idiCSQl3DJIFnfGW{IESg[IF6eyxiSVO1NF0xNjF2OUWg{txO NXO0fYpnOTh2NkewNFc>
HeLa cells Mkf2R5l1d3SxeHnjbZR6KGG|c3H5 NWjrSIJRPDhiaB?= MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF1KGyjZzDwbIF{\SCxZjDndo94fGhiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0zNjlizszN MlHuNVk4OTF7OEe=
A549 cells MV;DfZRwfG:6aXPpeJkh[XO|YYm= MW[0PEBp M4PkNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XRibHHnJJBp[XOnIH;mJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTR5IN88US=> MnnPNVk4OTF7OEe=
MCF7 cells NUXyXXNuS3m2b4TvfIlkcXS7IHHzd4F6 NU\HVVByPDhiaB?= MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF1KGyjZzDwbIF{\SCxZjDndo94fGhiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yNjRizszN MXexPVcyOTl6Nx?=
MT4 cells M{jEbmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVy5OkBp MoLIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXQ1KGOnbHzzJIlv\mWldHXkJJdqfGhiSGTMWk0yKGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEOFNUC9NE4yKM7:TR?= MXSyNVc1OTF|MB?=
CCRF-CEM cells M4LGXXBzd2yrZnXyZZRqd25iYYPzZZk> MmnnPVYhcA>? M1rHTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1PSSk1ETU1iY3XscJMh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhS0N3ME2xJO69VQ>? MlXTNlE4PDFzM{C=
WIL2-NS cells MmHUVJJwdGmoZYLheIlwdiCjc4PhfS=> NF\memo6PiCq MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFeLTEKtUnMh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygR2M2OD1|IN88US=> M1rOPVIyPzRzMUOw
CCRF-SB cells NFi3RmZRem:uaX\ldoF1cW:wIHHzd4F6 MnS1PVYhcA>? MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tV2Ih[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygR2M2OD1zLkGg{txO NITaclQzOTd2MUGzNC=>
human DU145 cells MV3Qdo9tcW[ncnH0bY9vKGG|c3H5 MWG5OkBp NXWwephGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBESzVyPUKg{txO MnHPNlE4PDFzM{C=
human HepG2 cells M1jEfnBzd2yrZnXyZZRqd25iYYPzZZk> NWTkbGRFQTZiaB?= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDl4IHjyd{BjgSCPVGSgZZN{[XluIFPDOVA:QCEQvF2= M1rocFIyPzRzMUOw
MCF7 cells MlKzVJJwdGmoZYLheIlwdiCjc4PhfS=> NIO2O|E6PiCq M3fCeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTNwMjFOwG0> MoS3NlE4PDFzM{C=
SK-MEL-28 cells MXLQdo9tcW[ncnH0bY9vKGG|c3H5 M17mWlk3KGh? NEXYO|RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjZoTldkA6PiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwQVE2KM7:TR?= M3;Re|IyPzRzMUOw
MCF7 cells MontR5l1d3SxeHnjbZR6KGG|c3H5 M1PYVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMtKEmFNUC9Nk44QSEQvF2= NVLwSGNOOjN2MUG5NVU>
mouse S49 cells M4\2bGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4HzO|czKGh? Ml3vR5l1d3SxeHnjbZR6KGGpYXnud5Qhf2muZDD0fZBmKG2xdYPlJHM1QSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhfHK7cHHuJIJtfWViZYjjcJV{cW:wIHHzd4F6NCCHQ{WwQVgh|ryP MkPmNlIyPjV6
Colo-357 cells NFjWNG1EgXSxdH;4bYNqfHliYYPzZZk> NF7zWlNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEd2yxLUO1O{Bk\WyuczDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzygTWM2OD14LkGyJO69VQ>? M1W3OlIxQTNyMUKz
Aspc-1 cells MYjDfZRwfG:6aXPpeJkh[XO|YYm= MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBd5BkNTFiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUC9Nk41PSEQvF2= NG\MXpYzODl|MEGyNy=>
A549 cells NWruRWFWS3m2b4TvfIlkcXS7IHHzd4F6 NGH3eJI1QCCq MmXTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUS3JO69VQ>? MUOyNlcxPTByMR?=
MCF7 cells NHe0UWVEgXSxdH;4bYNqfHliYYPzZZk> NUfsXm0{PDhiaB?= Ml3TR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGuOEDPxE1? M3PPVVIzPzB3MECx
Patu-02 cells M1rVSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmSyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS1yMjDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF06NjZ7IN88US=> MXKyNFk{ODF{Mx?=
Patu-T cells Ml3PR5l1d3SxeHnjbZR6KGG|c3H5 NIXmOJpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBR[XS3LWSgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVA:PC5yOTFOwG0> MUWyNFk{ODF{Mx?=
Patu-S cells M1vjOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX3kOWs5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWGG2dT3TJINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxRTFzLkC3JO69VQ>? MW[yNFk{ODF{Mx?=
T3M4 cells M4HyWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmnaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFNOPCClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3ME2yMlY{KM7:TR?= MlfsNlA6OzBzMkO=
human PANC1 cells MnjGR5l1d3SxeHnjbZR6KGG|c3H5 NH;4d4lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSU6FMTDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF03NjN7IN88US=> NVq0OppXOjB7M{CxNlM>
human DAN-G cells MYHDfZRwfG:6aXPpeJkh[XO|YYm= NIrqU3BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFSU5vRzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF01NjB4IN88US=> MmT1NlA6OzBzMkO=
HeLa cells NULpW41KS3m2b4TvfIlkcXS7IHHzd4F6 MXm0PEBp MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Mj65JO69VQ>? M{XmRVIzPzB3MECx
WEHI164 cells NHLxfHFRem:uaX\ldoF1cW:wIHHzd4F6 NXrHZoZ[OyCmYYnz MoTMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCZRVjJNVY1KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[2:wdnXyd4lwdiCjc4PhfUwhUUN3ME2wMlAyPSEQvF2= MnTUNVY3PDNyNEC=
WIL-2NS cells NH\rbYNRem:uaX\ldoF1cW:wIHHzd4F6 M4PF[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iV1nMMVJPWyClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OyEQvF2= NIS1UIMyPzJ3NE[2PS=>
WEHI164 cells NEnBVXpRem:uaX\ldoF1cW:wIHHzd4F6 NXjJblFwPzJiaB?= NXfINYZwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDXSWhKOTZ2IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NF0xNjBzNzFOwG0> Mn3vNVA4PTd5MEi=

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Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (197.13 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 152.18
Formula

C5H4N4S

CAS No. 50-44-2
Storage powder
in solvent
Synonyms N/A
Smiles C1=NC2=C(N1)C(=S)N=CN2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04770922 Enrolling by invitation -- Acute Lymphoblastic Leukemia Pediatric|Adverse Drug Event Cipherome Inc.|Stanford University February 23 2021 --
NCT03022747 Unknown status Drug: Allopurinol|Drug: Standard treatment Lymphoblastic Leukemia Acute Childhood Vastra Gotaland Region January 2017 Phase 2
NCT03920813 Enrolling by invitation Drug: Mercaptopurine Acute Lymphoblastic Leukemia Shandong University January 2015 Phase 4
NCT02046694 Completed Drug: Allopurinol Acute Lymphoblastic Leukemia (ALL) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins January 6 2014 Early Phase 1
NCT01324336 Completed Drug: 6-Mercaptopurine Acute Lymphoblastic Leukemia Children''s Mercy Hospital Kansas City|Midwest Cancer Alliance July 2011 --

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID