Mercaptopurine (6-MP)

For research use only.

Catalog No.S1305

6 publications

Mercaptopurine (6-MP) Chemical Structure

CAS No. 50-44-2

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

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Selleck's Mercaptopurine (6-MP) has been cited by 6 publications

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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Targets
PRPP Amidotransferase [2]
In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 leukemia cells NXPGcok2TnWwY4Tpc44h[XO|YYm= M4fyZ2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDvckBufWy2aXTyeYcuemW|aYP0ZY51KExzMkGwJIxmfWunbXnhJINmdGy|LDDJR|UxRTBwMEK0JO69VQ>? NHX3dYMyQTB4MUC3
MT4 cells MkfVVJJwdGmoZYLheIlwdiCjc4PhfS=> MoXVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPVESgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNUDPxE1? M1Sxd|E4OjV2Nk[5
human CCRF-CEM cells M2XXdXBzd2yrZnXyZZRqd25iYYPzZZk> Ml70RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFQ2LGMWNGVSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OSEQvF2= MnrNNVczPTR4Nkm=
human CCRF-SB cells Mly1VJJwdGmoZYLheIlwdiCjc4PhfS=> NV24bY9lSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNVOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1zIN88US=> NI\HSmUyPzJ3NE[2PS=>
human SK-MEL-28 cells M3nXSHBzd2yrZnXyZZRqd25iYYPzZZk> Ml;yRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSz3NSWwuOjhiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTF3IN88US=> M1X6b|E4OjV2Nk[5
human MCF7 cells NFLaNZZRem:uaX\ldoF1cW:wIHHzd4F6 M3fxXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9N{DPxE1? MkfQNVczPTR4Nkm=
human HepG2 cells NWXJeGw3WHKxbHnm[ZJifGmxbjDhd5NigQ>? NXLjcFZwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:QCEQvF2= M3LEbFE4OjV2Nk[5
human DU145 cells NHvZWFFRem:uaX\ldoF1cW:wIHHzd4F6 M2ruR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIh|ryP M1PwR|E4OjV2Nk[5
mouse J774.A1 cells MoPMVJJwdGmoZYLheIlwdiCjc4PhfS=> M2jE[FMh\GG7cx?= MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEp5N{SuRVEh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBkd264ZYLzbY9vKGG|c3H5MEBKSzVyPUCuNFA{KM7:TR?= NX[5UmdxOTZ4NEOwOFA>
HEK293 cells MYjQdo9tcW[ncnH0bY9vKGG|c3H5 MnrKN{Bl[Xm| NHTpR2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhGUzJ7MzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHPvcpZmenOrb36gZZN{[XluIFnDOVA:OC5yMEeg{txO NGPjelcyPjZ2M{C0NC=>
mouse J774 cells Mn\mVJJwdGmoZYLheIlwdiCjc4PhfS=> M1rhbVczKGh? MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEp5N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxRTBwMECzJO69VQ>? M2jWUlExPzV5N{C4
human PBMC NUH4bVBPTnWwY4Tpc44h[XO|YYm= M4P1V|Qh\GG7cx?= M1HRcmlvcGmkaYTpc44hd2ZiVDDj[YxtKG2rdH;n[Y4ucW6mdXPl[EBjdGG|dH;n[Y5me2m|IHnuJIh2dWGwIGDCUWMh[W[2ZYKgOEBl[Xm|LDDJR|UxRTBwMUS5OUDPxE1? NX;5UodlOTh2NkewNFc>
HeLa cells MXLDfZRwfG:6aXPpeJkh[XO|YYm= NYjBVFB2PDhiaB?= NGLlc5NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG2IHzh[{BxcGG|ZTDv[kBoem:5dHigZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{Lkmg{txO NYOyXVR6OTl5MUG5PFc>
A549 cells MX;DfZRwfG:6aXPpeJkh[XO|YYm= NFzk[5k1QCCq M2LGe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XRibHHnJJBp[XOnIH;mJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTR5IN88US=> MWexPVcyOTl6Nx?=
MCF7 cells MX\DfZRwfG:6aXPpeJkh[XO|YYm= NWTJSYtoPDhiaB?= MoW4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BifCCuYXegdIhie2Vib3[g[5Jwf3SqIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OS52IN88US=> MUGxPVcyOTl6Nx?=
MT4 cells NYfUWmxDS3m2b4TvfIlkcXS7IHHzd4F6 NVXlfJVxQTZiaB?= NXzvZYZMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVR2IHPlcIx{KGmwZnXjeIVlKHerdHigTHRNXi1zIHHmeIVzKDl4IHjyd{BjgSCPVGSgZZN{[XluIFPDOVA:OC5zIN88US=> MkHMNlE4PDFzM{C=
CCRF-CEM cells M1T6bXBzd2yrZnXyZZRqd25iYYPzZZk> MY[5OkBp MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tR2VOKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;MTFOwG0> NXT0WWU{OjF5NEGxN|A>
WIL2-NS cells MVnQdo9tcW[ncnH0bY9vKGG|c3H5 MlrRPVYhcA>? NGWyXYtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGfJUFIuVlNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhS0N3ME2zJO69VQ>? MV[yNVc1OTF|MB?=
CCRF-SB cells NYnkTZRJWHKxbHnm[ZJifGmxbjDhd5NigQ>? NYTrVG5uQTZiaB?= NWfSXlI6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNVOEIHPlcIx{KGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEOFNUC9NU4yKM7:TR?= NX3r[Yx3OjF5NEGxN|A>
human DU145 cells M1vzN3Bzd2yrZnXyZZRqd25iYYPzZZk> NYm3R5J6QTZiaB?= M2HJNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygR2M2OD1{IN88US=> MlvsNlE4PDFzM{C=
human HepG2 cells Mo\yVJJwdGmoZYLheIlwdiCjc4PhfS=> MXK5OkBp NWXUW41RSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBESzVyPUig{txO M4W3WVIyPzRzMUOw
MCF7 cells M1j0ZXBzd2yrZnXyZZRqd25iYYPzZZk> Mlq0PVYhcA>? MkPYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDl4IHjyd{BjgSCPVGSgZZN{[XluIFPDOVA:Oy5{IN88US=> MofRNlE4PDFzM{C=
SK-MEL-28 cells M3TtNHBzd2yrZnXyZZRqd25iYYPzZZk> MYq5OkBp M{XKd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1utUWVNNTJ6IHPlcIx{KGGodHXyJFk3KGi{czDifUBOXFRiYYPzZZktKEOFNUC9NVUh|ryP NXXBc4JlOjF5NEGxN|A>
MCF7 cells M{PmVGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyPUKuO|kh|ryP MXOyN|QyOTlzNR?=
mouse S49 cells MXvDfZRwfG:6aXPpeJkh[XO|YYm= MUi3NkBp Mn;OR5l1d3SxeHnjbZR6KGGpYXnud5Qhf2muZDD0fZBmKG2xdYPlJHM1QSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhfHK7cHHuJIJtfWViZYjjcJV{cW:wIHHzd4F6NCCHQ{WwQVgh|ryP M1fyfFIzOTZ3OB?=
Colo-357 cells MUDDfZRwfG:6aXPpeJkh[XO|YYm= M33hfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNwdG9vM{W3JINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxRTZwMUKg{txO MnvNNlA6OzBzMkO=
Aspc-1 cells NWHzcGlRS3m2b4TvfIlkcXS7IHHzd4F6 M1H4eGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{eGNvMTDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF0zNjR3IN88US=> NYfUfms3OjB7M{CxNlM>
A549 cells MWDDfZRwfG:6aXPpeJkh[XO|YYm= M3zHNFQ5KGh? MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NEeg{txO Mo\6NlI4ODVyMEG=
MCF7 cells NETlRlFEgXSxdH;4bYNqfHliYYPzZZk> MYm0PEBp MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT60JO69VQ>? M2\0W|IzPzB3MECx
Patu-02 cells NWC2b|JuS3m2b4TvfIlkcXS7IHHzd4F6 MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQZZR2NTB{IHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVkvPjlizszN NGjocVYzODl|MEGyNy=>
Patu-T cells NYj4WHp4S3m2b4TvfIlkcXS7IHHzd4F6 MknER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVQvODlizszN Ml7MNlA6OzBzMkO=
Patu-S cells MYrDfZRwfG:6aXPpeJkh[XO|YYm= M3rDe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBifHVvUzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF0yOS5yNzFOwG0> MkXjNlA6OzBzMkO=
T3M4 cells NHLyfpBEgXSxdH;4bYNqfHliYYPzZZk> MojsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFNOPCClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3ME2yMlY{KM7:TR?= MUKyNFk{ODF{Mx?=
human PANC1 cells MYXDfZRwfG:6aXPpeJkh[XO|YYm= NVvse4ZzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmduIFnDOVA:Pi5|OTFOwG0> MXqyNFk{ODF{Mx?=
human DAN-G cells MWnDfZRwfG:6aXPpeJkh[XO|YYm= MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDERW4uTyClZXzsd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{whUUN3ME20MlA3KM7:TR?= MXmyNFk{ODF{Mx?=
HeLa cells NX3VR|k{S3m2b4TvfIlkcXS7IHHzd4F6 M13Wd|Q5KGh? NELuNWlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Nk46KM7:TR?= NFTOb24zOjdyNUCwNS=>
WEHI164 cells NHe1UFRRem:uaX\ldoF1cW:wIHHzd4F6 Ml3VN{Bl[Xm| M2foWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViV1XITVE3PCClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGOxbo\ldpNqd25iYYPzZZktKEmFNUC9NE4xOTVizszN MYSxOlY1OzB2MB?=
WIL-2NS cells M2DZeHBzd2yrZnXyZZRqd25iYYPzZZk> MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFeLTD2yUnMh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVMh|ryP MXqxO|I2PDZ4OR?=
WEHI164 cells Mle2VJJwdGmoZYLheIlwdiCjc4PhfS=> NH;neJo4OiCq NWe1cVRHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDXSWhKOTZ2IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA4OiCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NF0xNjBzNzFOwG0> NUnJZZBtOTB5NUe3NFg>

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Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (197.13 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 152.18
Formula

C5H4N4S

CAS No. 50-44-2
Storage powder
in solvent
Synonyms N/A
Smiles C1=NC2=C(N1)C(=S)N=CN2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022747 Unknown status Drug: Allopurinol|Drug: Standard treatment Lymphoblastic Leukemia Acute Childhood Vastra Gotaland Region January 2017 Phase 2
NCT04304950 Recruiting Drug: Evening Group|Drug: Morning Group Inflammatory Bowel Diseases Rush University Medical Center April 25 2016 Phase 4
NCT03920813 Enrolling by invitation Drug: Mercaptopurine Acute Lymphoblastic Leukemia Shandong University January 2015 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID