Mercaptopurine (6-MP)

For research use only.

Catalog No.S1305

4 publications

Mercaptopurine (6-MP) Chemical Structure

CAS No. 50-44-2

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

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Selleck's Mercaptopurine (6-MP) has been cited by 4 publications

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Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
Targets
PRPP Amidotransferase [2]
In vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 leukemia cells NXLnb2NFTnWwY4Tpc44h[XO|YYm= M4PZZWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDvckBufWy2aXTyeYcuemW|aYP0ZY51KExzMkGwJIxmfWunbXnhJINmdGy|LDDJR|UxRTBwMEK0JO69VQ>? M{[4WlE6ODZzMEe=
MT4 cells MnP5VJJwdGmoZYLheIlwdiCjc4PhfS=> MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2WNDDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6xJO69VQ>? NYXZTJkzOTd{NUS2Olk>
human CCRF-CEM cells NHvQe|lRem:uaX\ldoF1cW:wIHHzd4F6 MnvERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFQ2LGMWNGVSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OSEQvF2= MVSxO|I2PDZ4OR?=
human CCRF-SB cells NED3PZpRem:uaX\ldoF1cW:wIHHzd4F6 NUDXN4xYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNVOEIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1zIN88US=> M1LCcVE4OjV2Nk[5
human SK-MEL-28 cells NFrLbZZRem:uaX\ldoF1cW:wIHHzd4F6 M2\0V2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1utUWVNNTJ6IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1zNTFOwG0> MWixO|I2PDZ4OR?=
human MCF7 cells M1j4N3Bzd2yrZnXyZZRqd25iYYPzZZk> MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUOg{txO M4f4[lE4OjV2Nk[5
human HepG2 cells MYTQdo9tcW[ncnH0bY9vKGG|c3H5 M1\1cWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVgh|ryP M4rYNVE4OjV2Nk[5
human DU145 cells NEfFc|FRem:uaX\ldoF1cW:wIHHzd4F6 M1XZUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIh|ryP MV2xO|I2PDZ4OR?=
mouse J774.A1 cells NYDTZZNTWHKxbHnm[ZJifGmxbjDhd5NigQ>? NVXwNVNoOyCmYYnz MoTZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCMN{e0MmEyKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[2:wdnXyd4lwdiCjc4PhfUwhUUN3ME2wMlAxOyEQvF2= M{e4[lE3PjR|MESw
HEK293 cells NHXqdWRRem:uaX\ldoF1cW:wIHHzd4F6 NWLPUIRJOyCmYYnz M1u0OWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTGVMOjl|IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiY3;ueoVze2mxbjDhd5NigSxiSVO1NF0xNjByNzFOwG0> NXnwU4hrOTZ4NEOwOFA>
mouse J774 cells MXrQdo9tcW[ncnH0bY9vKGG|c3H5 NXjJNFlXPzJiaB?= MkDKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCMN{e0JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iClZXzsJIdzd3e2aDDh[pRmeiB5MjDodpMh[nliTWTUJI1mfGixZDygTWM2OD1yLkCwN{DPxE1? MYCxNFc2PzdyOB?=
human PBMC NUHjPIpXTnWwY4Tpc44h[XO|YYm= NXG0N3VnPCCmYYnz MYLJcohq[mm2aX;uJI9nKFRiY3XscEBucXSxZ3XuMYlv\HWlZXSgZoxie3SxZ3Xu[ZNqeyCrbjDoeY1idiCSQl3DJIFnfGW{IESg[IF6eyxiSVO1NF0xNjF2OUWg{txO M2fYT|E5PDZ5MEC3
HeLa cells NH6xO5FEgXSxdH;4bYNqfHliYYPzZZk> Mn3BOFghcA>? MmXKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BifCCuYXegdIhie2Vib3[g[5Jwf3SqIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oi57IN88US=> M4i3UVE6PzFzOUi3
A549 cells M2D0dGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYn6[nJuPDhiaB?= M1fDN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XRibHHnJJBp[XOnIH;mJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTR5IN88US=> Ml\sNVk4OTF7OEe=
MCF7 cells MoLHR5l1d3SxeHnjbZR6KGG|c3H5 MWC0PEBp M2ftSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XRibHHnJJBp[XOnIH;mJIdzd3e2aDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTFwNDFOwG0> MW[xPVcyOTl6Nx?=
MT4 cells MYrDfZRwfG:6aXPpeJkh[XO|YYm= NHjud4w6PiCq NEHjSVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXDRiY3XscJMhcW6oZXP0[YQhf2m2aDDIWGxXNTFiYX\0[ZIhQTZiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NF0xNjFizszN M1nPfFIyPzRzMUOw
CCRF-CEM cells NYLUdndmWHKxbHnm[ZJifGmxbjDhd5NigQ>? NWK1UFdwQTZiaB?= NYnD[ok6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNUOHTTDj[YxteyCjZoTldkA6PiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwQVEh|ryP M{nq[|IyPzRzMUOw
WIL2-NS cells MnnFVJJwdGmoZYLheIlwdiCjc4PhfS=> MXe5OkBp Ml;kRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZSVyyMW5UKGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;MzFOwG0> NXrFVVBKOjF5NEGxN|A>
CCRF-SB cells NUHmVHpUWHKxbHnm[ZJifGmxbjDhd5NigQ>? MoTiPVYhcA>? NGq1W5dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuW0JiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhS0N3ME2xMlEh|ryP NILpPHYzOTd2MUGzNC=>
human DU145 cells M2PvdXBzd2yrZnXyZZRqd25iYYPzZZk> NYjXd4JlQTZiaB?= NHfqS5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;MjFOwG0> MYGyNVc1OTF|MB?=
human HepG2 cells NGDwXYVRem:uaX\ldoF1cW:wIHHzd4F6 MUK5OkBp M{e1e2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IF3UWEBie3OjeTygR2M2OD16IN88US=> MmjzNlE4PDFzM{C=
MCF7 cells MWjQdo9tcW[ncnH0bY9vKGG|c3H5 MUS5OkBp M4j6S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliTWTUJIF{e2G7LDDDR|UxRTNwMjFOwG0> NVK4Z493OjF5NEGxN|A>
SK-MEL-28 cells NYK3WlBbWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1G3Nlk3KGh? MmjpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSz3NSWwuOjhiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhS0N3ME2xOUDPxE1? MXWyNVc1OTF|MB?=
MCF7 cells NID3SYZEgXSxdH;4bYNqfHliYYPzZZk> MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzMEBKSzVyPUKuO|kh|ryP MojINlM1OTF7MUW=
mouse S49 cells MofCR5l1d3SxeHnjbZR6KGG|c3H5 NFPmOWg4OiCq NVvyd4RRS3m2b4TvfIlkcXS7IHHnZYlve3Rid3ns[EB1gXCnIH3veZNmKFN2OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nlidIL5dIFvKGKudXWg[ZhkdHW|aX;uJIF{e2G7LDDFR|UxRThizszN M3yyflIzOTZ3OB?=
Colo-357 cells M1jSd2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDc4xwNTN3NzDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF03NjF{IN88US=> MXWyNFk{ODF{Mx?=
Aspc-1 cells NX\3SnBCS3m2b4TvfIlkcXS7IHHzd4F6 MmTqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRZNx[y1zIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVIvPDVizszN NHSzZVMzODl|MEGyNy=>
A549 cells MXvDfZRwfG:6aXPpeJkh[XO|YYm= M3W2elQ5KGh? Mne3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUS3JO69VQ>? M{TUSVIzPzB3MECx
MCF7 cells NXzabnoyS3m2b4TvfIlkcXS7IHHzd4F6 NWW3XWtQPDhiaB?= NEnJU|NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NU41KM7:TR?= NWnZR4J4OjJ5MEWwNFE>
Patu-02 cells NF;6eG9EgXSxdH;4bYNqfHliYYPzZZk> Mn3DR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS1yMjDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF06NjZ7IN88US=> MUWyNFk{ODF{Mx?=
Patu-T cells NWOy[XF4S3m2b4TvfIlkcXS7IHHzd4F6 MknnR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVIF1fS2WIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVQvODlizszN NEHkZZAzODl|MEGyNy=>
Patu-S cells NGL2NWFEgXSxdH;4bYNqfHliYYPzZZk> NVf1RohCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWGG2dT3TJINmdGy|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pLDDJR|UxRTFzLkC3JO69VQ>? NWT5PZlSOjB7M{CxNlM>
T3M4 cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= NXTXNIxRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXDOPNDDj[YxteyCkeTDjdpl{fGGuII\pc4xmfCC|dHHpcolv\yxiSVO1NF0zNjZ|IN88US=> NHLUUnAzODl|MEGyNy=>
human PANC1 cells Mnm1R5l1d3SxeHnjbZR6KGG|c3H5 M4jjZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBCVkNzIHPlcIx{KGK7IHPyfZN1[WxidnnvcIV1KHO2YXnubY5oNCCLQ{WwQVYvOzlizszN NWXuRmZ1OjB7M{CxNlM>
human DAN-G cells MVrDfZRwfG:6aXPpeJkh[XO|YYm= MlXBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSGFPNUdiY3XscJMh[nliY4L5d5RidCC4aX;s[ZQhe3SjaX7pcoctKEmFNUC9OE4xPiEQvF2= Mk\FNlA6OzBzMkO=
HeLa cells M2n2TmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYC0PEBp NUizVIJZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIvQSEQvF2= NGLhclEzOjdyNUCwNS=>
WEHI164 cells M3fxeXBzd2yrZnXyZZRqd25iYYPzZZk> NIWwd3k{KGSjeYO= NYi3WlhOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDXSWhKOTZ2IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiY3;ueoVze2mxbjDhd5NigSxiSVO1NF0xNjBzNTFOwG0> MnHCNVY3PDNyNEC=
WIL-2NS cells MW\Qdo9tcW[ncnH0bY9vKGG|c3H5 Mn;3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCZSVytNm5UKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{KM7:TR?= MXWxO|I2PDZ4OR?=
WEHI164 cells NUXSc4VWWHKxbHnm[ZJifGmxbjDhd5NigQ>? NUnP[Zp1PzJiaB?= MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKFeHSFmxOlQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIHPlcIwh\3Kxd4ToJIFnfGW{IEeyJIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyPUCuNFE4KM7:TR?= MYOxNFc2PzdyOB?=

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Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (197.13 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 152.18
Formula

C5H4N4S

CAS No. 50-44-2
Storage powder
in solvent
Synonyms N/A
Smiles C1=NC2=C(N1)C(=S)N=CN2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022747 Unknown status Drug: Allopurinol|Drug: Standard treatment Lymphoblastic Leukemia Acute Childhood Vastra Gotaland Region January 2017 Phase 2
NCT04304950 Recruiting Drug: Evening Group|Drug: Morning Group Inflammatory Bowel Diseases Rush University Medical Center April 25 2016 Phase 4
NCT03920813 Enrolling by invitation Drug: Mercaptopurine Acute Lymphoblastic Leukemia Shandong University January 2015 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID