For research use only.
CAS No. 50-44-2
Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
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Choose Selective DNA/RNA Synthesis Inhibitors
|Description||Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.|
Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection.  Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. 
|In vitro||DMSO||30 mg/mL (197.13 mM)|
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|% DMSO % % Tween 80 % ddH2O|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03022747||Unknown status||Drug: Allopurinol|Drug: Standard treatment||Lymphoblastic Leukemia Acute Childhood||Vastra Gotaland Region||January 2017||Phase 2|
|NCT04304950||Recruiting||Drug: Evening Group|Drug: Morning Group||Inflammatory Bowel Diseases||Rush University Medical Center||April 25 2016||Phase 4|
|NCT03920813||Enrolling by invitation||Drug: Mercaptopurine||Acute Lymphoblastic Leukemia||Shandong University||January 2015||Phase 4|
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