MG-132

For research use only.

Catalog No.S2619 Synonyms: Z-Leu-Leu-Leu-al

1335 publications

MG-132 Chemical Structure

CAS No. 1211877-36-9

MG132 (Z-Leu-Leu-Leu-al) is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 μM and 1.2 μM for the inhibition of proteasome and calpain, respectively. MG132 activates autophagy and induces apoptosis in tumor cells.

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Selleck's MG-132 had a noticeably greater effect when compared with similar products from Sigma: This is directly due to using the (S, R, S) - (-) - 2 configuration.

P21 protein can be degraded through ubiquitylation pathway. Inhibition of proteasome activities results in the accumulation of P21 protein, therefore, the more powerful the inhibiting effect, the more P21 protein is accumulated. (testing protein: P21; Cell line: Hela; treatment condition: final concentration of MG-132 is 5μM, with a 6 hour treatment time)

Selleck's MG-132 has been cited by 1335 publications

Purity & Quality Control

Choose Selective Proteasome Inhibitors

Biological Activity

Description MG132 (Z-Leu-Leu-Leu-al) is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 μM and 1.2 μM for the inhibition of proteasome and calpain, respectively. MG132 activates autophagy and induces apoptosis in tumor cells.
Targets
Proteasome [9]
(Cell-free assay)
100 nM
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LP-1 NV:3cWVISXCxcITvd4l{KEG|c3H5 NFTzV2Y{ODBibl2= MnzYNlQhcA>? NYqyZ2RyTE2VTx?= MkHYTY5lfWOnczDhdI9xfG:|aYOgZpkhcW6lcnXhd4lv\yClbHXheoVlKFCDUmCgcIV3\WxiYX7kJJJm\HWlaX7nJG1kdC1zIIDyc5RmcW5ibHX2[Yw> M{LRblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OUW4OVg6Lz5zNUm1PFU5QTxxYU6=
PC3 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nibFIxKM7:TR?= MWe0PEBp MWjEUXNQ M4\zZWlEPTB;MD62JO69VQ>? NFy5UZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[4OlU{Pyd-MU[2PFY2Ozd:L3G+
PC12 MlXUSpVv[3Srb36gRZN{[Xl? MUWxNFAh|ryPwrC= NXvoUod[OjRiaB?= NEL0WoZFVVOR NFLBXYFKdmirYnn0d{A3NU:KRFGtJIFv\CCKMl:yMYlv\HWlZXSgZ5l1d3SxeHnjbZR6 M3\4SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW4OFU1Lz5zN{G1PFQ2PDxxYU6=
LPS-stimulated RAW264.7 cells NYC0T3ZjTnWwY4Tpc44hSXO|YYm= NHP6U4ZFVVOR MlXFTY5pcWKrdIOgUmYuc2GycHHCJGRPSSCkaX7kbY5o MmHvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MEeyO|coRjF5NEC3Nlc4RC:jPh?=
OCI-Ly3 MnS2SpVv[3Srb36gRZN{[Xl? NHXhT2YyOCEQvF5CpC=> NVXZWYFkPCCq M4HZOGROW09? NWXZN5g5UW6mdXPld{BpfW2jbjDJb4FxeGGEYXzwbIEhe3SjYnnsbZpifGmxbjD3bZRpKEWFNUCgc4YhOSEQvF2= NVy2boRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwNlQyOTNpPkG4NFI1OTF|PD;hQi=>
A2780 cDDP NHrkcnhCeG:ydH;zbZMhSXO|YYm= NFvCXIkzPCCq MkTWSG1UVw>? NX\EbpBJUW6mdXPld{BieG:ydH;zbZMh[nliaX7obYJqfGmwZzDQWGVPKGSnZ4Lh[IF1cW:w NHXSZ4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[4OFAyQCd-MUe2PFQxOTh:L3G+
COS-7 Mm\GR5l1d3SxeHnjJGF{e2G7 NF\R[YEyOCEQvF2= MWfEUXNQ NHnK[oJKSzVyPEGwJO69VQ>? MlTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyOEiwPVcoRjF6MEi4NFk4RC:jPh?=
HuH-7 M13t[GN6fG:2b4jpZ{BCe3OjeR?= MnrqNVAh|ryP MUHEUXNQ M2n1PWlEPTB:MUCg{txO MnG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyOEiwPVcoRjF6MEi4NFk4RC:jPh?=
Hepa-1c1c7 M1POS2Z2dmO2aX;uJGF{e2G7 M13WN|I2KM7:TR?= M3[zelYhcA>? NVvGdYg1TE2VTx?= NWLxRZVJUW6lcnXhd4V{KE6{ZkKgdJJwfGWrbjDs[ZZmdA>? M{PNR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{myOVQ1Lz5{MEO5NlU1PDxxYU6=
IPC227F NInrcotEgXSxdH;4bYMhSXO|YYm= M2HxTFEh|ryP M2Xa[|Q5KGh? MmDVSG1UVw>? MoXUTWM2OD1yLkC3O{DPxE1? MlH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7MkS1NlgoRjJzOUK0OVI5RC:jPh?=
Calu6 MoDtSpVv[3Srb36gRZN{[Xl? MlXsNVAh|ryP MVuxPEBp MUPEUXNQ MYjTbYdvcW[rY3HueIx6KGGlY4XteYxifGW|IH\yZZRigGmwIIDy[YN2enOxch?= NUnKN3Y3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1NFY1QDZpPkKzOVA3PDh4PD;hQi=>
IFN-gamma-induced RAW264.7 M2T5[GZ2dmO2aX;uJGF{e2G7 NVPORXNLTE2VTx?= MofuTY5pcWKrdIOgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvODd5IN88US=> NEnGdGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3O|I4Pyd-MkKyO|czPzd:L3G+
HEK-293 M132U2tqdmG|ZTDBd5NigQ>? NH;tSY4zKGGwZDCyNEDPxE1? MWSyJIg> NXzI[YU4TE2VTx?= NGDySJpKdmirYnn0d{BEcFRvTDDhZ5Rqfmm2eTD3bZRpKEmFNUCgc4YhQSCwTR?= M3zyVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUSwO|kxLz5{M{W0NFc6ODxxYU6=
MCF10A MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofPNUDPxE1? M4f5N|czKGh? NGDUNotFVVOR NGrSVotKSzVyPUCuNlkh|ryP NYTieWt3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxOVMzODZpPkK0NVU{OjB4PD;hQi=>
MCF-7 NFPyR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HJcVEh|ryP NVOw[HJEPzJiaB?= MoTpSG1UVw>? NH7OfopKSzVyPUCuNVMh|ryP M2n2N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUWzNlA3Lz5{NEG1N|IxPjxxYU6=
HeLa MormT4lv[XOnIFHzd4F6 M4nSXVExKM7:TR?= M2[4TlEhcA>? MULEUXNQ NXnGNXl4UW6mdXPld{BRSVKSIHPs[YF3[WenIHL5JIlvcGmkaYTpcocheHKxc3Xhd49u\SCjY4Tpeol1gQ>? M1\0OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{KxPFM{Lz5{NEOyNVg{OzxxYU6=
MDA-MB-231 M3jwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLhNUDPxE1? NFrkb4o4OiCq M1LsemROW09? M1rNNmlEPTB;MD6xPEDPxE1? MlK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNUOyNFYoRjJ2MUWzNlA3RC:jPh?=
293T MnX0R5l1d3SxeHnjJGF{e2G7 NY[xWGJROTBizszN M1vkbFczKGh? NGjrWmxFVVOR Mn74TWM2ODx{IN88US=> NYO1T2d1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2NlUxQDhpPkK0OlI2ODh6PD;hQi=>
293T NVLmOXAyTnWwY4Tpc44hSXO|YYm= NWnNW2YyOTBizszN M{iyZ|I1KGh? NGi0XWdFVVOR MmTLUY9l\XKjdHXsfUBqdmS3Y3XzJIhm[XRvc3jvZ4s> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ{NUC4PEc,OjR4MkWwPFg9N2F-
NCI-H929 MWDDfZRwfG:6aXOgRZN{[Xl? MV2xJO69VQ>? NVXDfZFxPzJiaB?= Mn[wSG1UVw>? MlXoTWM2OD1yLkG3JO69VQ>? NGfSVYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[yOVA5QCd-MkS2NlUxQDh:L3G+
A-549 MXLDfZRwfG:6aXOgRZN{[Xl? NUfHbFFNPDBizszN Ml;VOFghcA>? M3[3fWROW09? NU\PVWRzUUN3MEyxNEDPxE1? M2\G[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nkm3OFk3Lz5{NE[5O|Q6PjxxYU6=
MCF-7 NGjTdoJEgXSxdH;4bYMhSXO|YYm= M4LOO|QxKM7:TR?= NUPhVXd2PDhiaB?= MmmwSG1UVw>? MVTJR|UxRTdwMzFOwG0> Mn3GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OUe0PVYoRjJ2Nkm3OFk3RC:jPh?=
SW-480 NFO3U2NEgXSxdH;4bYMhSXO|YYm= NUjWTGJqPDBizszN M3HUOlQ5KGh? NEDNUYtFVVOR NWDUb2JKUUN3ME20JO69VQ>? NHLRdFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[5O|Q6Pid-MkS2PVc1QTZ:L3G+
HL-60 MlGyR5l1d3SxeHnjJGF{e2G7 NHm2WXc1OCEQvF2= NXrmVVlCPDhiaB?= NFjQe|FFVVOR MXLJR|UxRDFyIN88US=> Ml\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OUe0PVYoRjJ2Nkm3OFk3RC:jPh?=
SMMC-7721 NXjLN4dpS3m2b4TvfIlkKEG|c3H5 NFPyS2c1OCEQvF2= NWfnVoNjPDhiaB?= M2fuWGROW09? NVPMN4R[UUN3ME23MlEh|ryP MlXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OUe0PVYoRjJ2Nkm3OFk3RC:jPh?=
LPS-stimulated RAW264.7 cells M2Lkb2Z2dmO2aX;uJGF{e2G7 NX7OUndjOjVizszN Mn\iSG1UVw>? NYj5NoFVUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMTFOwG0> MnLnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OUe0PVYoRjJ2Nkm3OFk3RC:jPh?=
lymphoblastoid NXvEOY9GTnWwY4Tpc44h[XO|YYm= MVXJR|UxKD1iMD6wNFIh|ryP NFjkZ3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m5Olk5Pyd-MUe5PVY6QDd:L3G+
LCL MYPGeY5kfGmxbjDhd5NigQ>? M3;Pd|EzKGh? Mk\zTWM2OCB;IECuNFAzKM7:TR?= NFrIXFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4O|YxQSd-MkC2PFc3ODl:L3G+
HL-60 MmjVSpVv[3Srb36gZZN{[Xl? MVPJR|UxKD1iMD6wOlgh|ryP M2jUU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{iwOlI{Lz5zNUe4NFYzOzxxYU6=
IPC227F NXrQUWdGTnWwY4Tpc44h[XO|YYm= Mmi3NUBp M3vRcWlEPTBiPTCwMlA4PyEQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJ{MEm4PEc,OTZ{MkC5PFg9N2F-
RAW264.7 NXzObGpkSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBie3OjeR?= MXSxPEBp MVnJR|UxKD1iMD6wPEDPxE1? NYG0[I1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlA3PzdpPkKyOlIxPjd5PD;hQi=>
RAW264.7 M3;NS2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZZN{[Xl? MoO5NVghcA>? NUPYXYtbUUN3MDC9JFAvOSEQvF2= M4HnflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEG5PFcyLz5{M{ixPVg4OTxxYU6=
RAW264.7 M4\ieWZ2dmO2aX;uJIF{e2G7 NHS0N5lKSzVyIE2gNE4yKM7:TR?= Ml;OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3OUe4PVQoRjJ2NUm3PFk1RC:jPh?=
RAW264.7 NXW1S4JZTnWwY4Tpc44h[XO|YYm= NXuybmVWOThiaB?= MoK5TWM2OCB;IECuNUDPxE1? NV73PGx{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVk5ODlpPkK0NlE6QDB7PD;hQi=>
RAW264.7 M37sPWZ2dmO2aX;uJIF{e2G7 MmW3NVghcA>? NH22ZpVKSzVyIE2gNE4yPSEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN{N{[2PEc,OjN|Mke2Olg9N2F-
RAW264.7 NH3aVJNHfW6ldHnvckBie3OjeR?= M{T6S|E5KGh? MWTJR|UxKD1iMD6xOUDPxE1? M2LHb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{W3NFE6Lz5{Nke1O|AyQTxxYU6=
RAW264.7 NFWyfnVCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIF{e2G7 NID5VnEyQCCq NWXpRmRLUUN3MDC9JFAvOThizszN NXT3cnZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNFMzQTFpPkK3NlA{OjlzPD;hQi=>
RAW264.7 MYDBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHHzd4F6 MkfQNUBp NHnl[oNKSzVyIE2gNE4zKM7:TR?= NYH2N|V[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzN|gzPjBpPkK5N|M5OjZyPD;hQi=>
MDA-MB-231 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MWnJR|UxKD1iMD6yOUDPxE1? NEDMdHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
MCF7 M{SxW2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFrJOHRKSzVyIE2gNE4{KM7:TR?= NXr0eIpbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
RAW264.7 Mk\iSpVv[3Srb36gZZN{[Xl? M{TkflE5KGh? M1OxXWlEPTBiPTCwMlM2KM7:TR?= M4HUNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMES0PFQ4Lz5{MUC0OFg1PzxxYU6=
RAW264.7 MWLBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHHzd4F6 Mm\RTWM2OCB;IECuOFM6KM7:TR?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4MUC2NEc,OjF3NkGwOlA9N2F-
HEK293 MULGeY5kfGmxbjDhd5NigQ>? MmH4NkBp NVTqNXE1UUN3MDC9JFAvPiEQvF2= NIXJUmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W0NFc6OCd-MkO1OFA4QTB:L3G+
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HAL-01 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTF|Nj60Nlkh|ryP NVXTSHFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjR7MkWvK|5USU6JRWK8M4E,
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CPC-N NHLsVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv6TWM2OD1zOEiuPVQ2KM7:TR?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OFkzPS9pPmPBUmdGWjxxYU6=
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NCI-H889 NFziVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLZVGhWUUN3ME2yNFkvPjB{IN88US=> NFm2bnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PDl{NT:nQnNCVkeHUkyvZV4>
MHH-CALL-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDJTWM2OD1{M{CuNlk5KM7:TR?= NYjiTFVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjR7MkWvK|5USU6JRWK8M4E,
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CHP-126 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?</