Mozavaptan

Synonyms: OPC-31260

Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.

Mozavaptan Chemical Structure

Mozavaptan Chemical Structure

CAS: 137975-06-5

Selleck's Mozavaptan has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.91%
99.91

Mozavaptan Related Products

Choose Selective Vasopressin Receptor Inhibitors

Biological Activity

Description Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.
Targets
Vasopressin receptor 2 [2] Vasopressin receptor 1 [2]
14 nM 1.2 μM
In vitro
In vitro Mozavaptan (OPC-31260) is a nonpeptide, orally effective competitive inhibitor of AVP with a V2:V1 receptor selectivity ratio of 25:1 indicating relative V2 receptor selectivity. [1] Mozavaptan (OPC-31260) inhibits AVP binding to V1 and V2 receptors in a competitive manner. [2]
In Vivo
In vivo Mozavaptan (OPC-31260) inhibits the antidiuretic action of exogenously administered AVP in water-loaded, alcohol-anaesthetized rats in a dose-dependent manner. OPC-31260 dose-dependently increases urine flow and decreased urine osmolality after oral administration at doses of 1 to 30 mg/kg in normal conscious rats. [2]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 10, 30, 100μg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 427.54 Formula

C27H29N3O2

CAS No. 137975-06-5 SDF Download Mozavaptan SDF
Smiles CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 85 mg/mL ( (198.81 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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