Metyrapone

Catalog No.S5416 Synonyms: NSC-25265, SU-4885

Metyrapone Chemical Structure

Molecular Weight(MW): 226.27

Metyrapone is an inhibitor of the enzyme steroid 11-beta-monooxygenase that inhibits adrenal steroid synthesis.

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Biological Activity

Description Metyrapone is an inhibitor of the enzyme steroid 11-beta-monooxygenase that inhibits adrenal steroid synthesis.
Targets
11β-HSD1 [1]
()
30 μM(Ki)
In vitro

Metyrapone is a well known inhibitor of 11β-hydroxylase, a key enzyme involved in the final step of cortisol biosynthesis. At higher concentrations, it also inhibits other steroidogenic enzymes such as cholesterol side chain cleavage enzyme. It is specific for 11β-HSD1 while it has little effect on 11β-HSD2 activity[1].

In vivo The administration of metyrapone to man, and animals such as the dog and sheep thus leads to a decrease in circulating levels of cortisol[1].

Protocol

Solubility (25°C)

In vitro DMSO 46 mg/mL (203.29 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 226.27
Formula

C14H14N2O

CAS No. 54-36-4
Storage powder
in solvent
Synonyms NSC-25265, SU-4885

Bio Calculators

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03491696 Recruiting Depressive Disorder|Hormone Disturbance Centre Hospitalier Rouffach|University Hospital Strasbourg France December 22 2018 Phase 4
NCT03491696 Recruiting Depressive Disorder|Hormone Disturbance Centre Hospitalier Rouffach|University Hospital Strasbourg France December 22 2018 Phase 4
NCT02297945 Unknown status Cushing''s Syndrome HRA Pharma April 2015 Phase 3
NCT02297945 Unknown status Cushing''s Syndrome HRA Pharma April 2015 Phase 3
NCT02406066 Completed Cocaine Use Disorder|Tobacco Use Disorder Embera NeuroTherapeutics Inc.|National Institute on Drug Abuse (NIDA) March 2015 Phase 1
NCT02406066 Completed Cocaine Use Disorder|Tobacco Use Disorder Embera NeuroTherapeutics Inc.|National Institute on Drug Abuse (NIDA) March 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID