Home Metabolism P450 (e.g. CYP17) inhibitor Metyrapone For research use only.

Metyrapone

Synonyms: NSC-25265, SU-4885

Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.

Metyrapone Chemical Structure

Metyrapone Chemical Structure

CAS: 54-36-4

Selleck's Metyrapone has been cited by 1 publication

Purity & Quality Control

Batch: S541601 DMSO] 46 mg/mL] false] ] ] false] ] ] false Purity: 99.97%
99.97

Metyrapone Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.
Targets
11β-HSD1 [1]
30 μM(Ki)
In vitro
In vitro Metyrapone is a well known inhibitor of 11β-hydroxylase, a key enzyme involved in the final step of cortisol biosynthesis. At higher concentrations, it also inhibits other steroidogenic enzymes such as cholesterol side chain cleavage enzyme. It is specific for 11β-HSD1 while it has little effect on 11β-HSD2 activity[1].
In Vivo
In vivo The administration of metyrapone to man, and animals such as the dog and sheep thus leads to a decrease in circulating levels of cortisol[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03491696 Unknown status
Depressive Disorder|Hormone Disturbance
Centre Hospitalier Rouffach|University Hospital Strasbourg France
 December 22 2018 Phase 4
NCT02406066 Completed
Cocaine Use Disorder|Tobacco Use Disorder
Embera NeuroTherapeutics Inc.|National Institute on Drug Abuse (NIDA)
 March 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 226.27 Formula

C14H14N2O
CAS No. 54-36-4 SDF --
Smiles CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 46 mg/mL ( (203.29 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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