Mycophenolic acid

For research use only.

Catalog No.S2487 Synonyms: Mycophenolate, RS-61443

8 publications

Mycophenolic acid Chemical Structure

CAS No. 24280-93-1

Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

Selleck's Mycophenolic acid has been cited by 8 publications

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Biological Activity

Description Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
In vitro

Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. [1] Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. [2] Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. [3] Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells. [4]

In vivo Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects. [3]


Solubility (25°C)

In vitro DMSO 64 mg/mL (199.78 mM)
Water Insoluble
Ethanol '5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.34


CAS No. 24280-93-1
Storage powder
in solvent
Synonyms Mycophenolate, RS-61443
Smiles CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04473924 Not yet recruiting Drug: Mycophenolate Mofetil Infection|Transplant;FailureKidney University of California San Francisco February 1 2022 Phase 2
NCT05005221 Not yet recruiting Behavioral: Automated text messages Kidney Transplant University of Michigan September 1 2021 Not Applicable
NCT04645589 Recruiting Drug: Myfortic Lupus Nephritis Novartis Pharmaceuticals|Novartis March 16 2021 --
NCT04622956 Recruiting Drug: Methotrexate Injectable Solution Graft Vs Host Disease|Hematopoietic Neoplasm University of Sao Paulo General Hospital|Libbs Farmacêutica LTDA October 7 2020 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID