Mycophenolic acid

Catalog No.S2487 Synonyms: Mycophenolate, RS-61443

Mycophenolic acid Chemical Structure

Molecular Weight(MW): 320.34

Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

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In DMSO USD 130 In stock
USD 60 In stock
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Biological Activity

Description Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
In vitro

Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. [1] Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. [2] Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. [3] Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells. [4]

In vivo Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects. [3]


Solubility (25°C)

In vitro DMSO 64 mg/mL (199.78 mM)
Ethanol 5 mg/mL (15.6 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.34


CAS No. 24280-93-1
Storage powder
in solvent
Synonyms Mycophenolate, RS-61443

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04039373 Recruiting Drug: BMS-986256|Drug: Mycophenolate Mofetil Healthy Participants Bristol-Myers Squibb July 22 2019 Phase 1
NCT03920059 Recruiting Drug: Mycophenolate Mofetil Lupus Nephritis Chulalongkorn University|Berlin Pharmaceutical Industry May 1 2019 Phase 4
NCT03591380 Recruiting Drug: Belimumab Kidney Transplantation University of Wisconsin Madison|GlaxoSmithKline|American College of Surgeons May 14 2019 Phase 1
NCT03769298 Recruiting Drug: Envarsus XR Kidney Pancreas Transplantation University of Wisconsin Madison|Veloxis Pharmaceuticals February 27 2019 Phase 2|Phase 3
NCT03678987 Enrolling by invitation Diagnostic Test: P-MPA concentration|Drug: mycophenolic acid Systemic Sclerosis|Gastrointestinal Complication Region Skane September 13 2018 --

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Dehydrogenase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID