Mycophenolic acid

Catalog No.S2487 Synonyms: Mycophenolate, RS-61443

Mycophenolic acid Chemical Structure

Molecular Weight(MW): 320.34

Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 990 In stock
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Biological Activity

Description Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
Targets
IMPDH [1]
In vitro

Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. [1] Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. [2] Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. [3] Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells. [4]

In vivo Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects. [3]

Protocol

Solubility (25°C)

In vitro DMSO 64 mg/mL (199.78 mM)
Ethanol 5 mg/mL (15.6 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.34
Formula

C17H20O6

CAS No. 24280-93-1
Storage powder
in solvent
Synonyms Mycophenolate, RS-61443

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02630628 Recruiting Lupus Nephritis The University of Hong Kong December 5 2015 Phase 4
NCT03128359 Recruiting Acute Leukemia|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Chronic Myelogenous Leukemia BCR-ABL1 Positive|Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Graft Versus Host Disease|Hodgkin Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma|Secondary Myelodysplastic Syndrome City of Hope Medical Center|National Cancer Institute (NCI) May 30 2017 Phase 2
NCT01011205 Completed Liver Transplantation Astellas Pharma Inc September 30 2009 Phase 3
NCT03221257 Recruiting Scleroderma Systemic|Interstitial Lung Disease Michael Roth|University of Michigan|Genentech Inc.|University of California Los Angeles November 28 2017 Phase 2
NCT02991768 Recruiting Diarrhea Pooja Budhiraja MD|University of Kansas Medical Center January 27 2017 Phase 2
NCT02383589 Active not recruiting Pemphigus Vulgaris Hoffmann-La Roche|Genentech Inc. May 26 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dehydrogenase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID