Catalog No.S2487 Synonyms: Mycophenolate, RS-61443
Molecular Weight(MW): 320.34
Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
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|Description||Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.|
Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.  Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs.  Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells.  Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells. 
|In vivo||Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects. |
|In vitro||DMSO||64 mg/mL (199.78 mM)|
|Ethanol||5 mg/mL (15.6 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02630628||Recruiting||Lupus Nephritis||The University of Hong Kong||December 5 2015||Phase 4|
|NCT03128359||Recruiting||Acute Leukemia|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Chronic Myelogenous Leukemia BCR-ABL1 Positive|Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Graft Versus Host Disease|Hodgkin Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma|Secondary Myelodysplastic Syndrome||City of Hope Medical Center|National Cancer Institute (NCI)||May 30 2017||Phase 2|
|NCT01011205||Completed||Liver Transplantation||Astellas Pharma Inc||September 30 2009||Phase 3|
|NCT03221257||Recruiting||Scleroderma Systemic|Interstitial Lung Disease||Michael Roth|University of Michigan|Genentech Inc.|University of California Los Angeles||November 28 2017||Phase 2|
|NCT02991768||Recruiting||Diarrhea||Pooja Budhiraja MD|University of Kansas Medical Center||January 27 2017||Phase 2|
|NCT02383589||Active not recruiting||Pemphigus Vulgaris||Hoffmann-La Roche|Genentech Inc.||May 26 2015||Phase 3|
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