5-methoxyflavone

Catalog No.S4782

5-methoxyflavone Chemical Structure

Molecular Weight(MW): 252.26

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

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Biological Activity

Description 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
Targets
DNA polymerase β [1]
()
In vitro

The treatment with 5-methoxyflavone (5-MF) at various times (3, 6, 12, 18 and 24 h) in MOLT-4 cells results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner[2].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: human leukemic MOLT-4, U937 cell lines and PBMCs
  • Concentrations: 0-100 μg/ml
  • Incubation Time: 24 h
  • Method: MOLT-4 or U937 or PBMC cells are treated with DMF or TMF or PMF, 5-MF or 2'-MF at various concentrations for 24 h, then the cell viability is determined by the MTT assay.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (198.2 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 252.26
Formula

C16H12O3

CAS No. 42079-78-7
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID