Mizagliflozin

For research use only.

Catalog No.S8939 Synonyms: KWA 0711

Mizagliflozin Chemical Structure

Molecular Weight(MW): 564.67

Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.

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Biological Activity

Description Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
Targets
human SGLT1 [1]
(Cell-free assay)
27 nM(Ki)

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 564.67
Formula

C28H44N4O8

CAS No. 666843-10-3
Storage powder
in solvent
Synonyms KWA 0711

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID