For research use only.
Catalog No.S9709 Synonyms: MDP
CAS No. 53678-77-6
Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.
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|Description||Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.|
MDP directly augments osteoblast differentiation and bone-forming gene expression by Runx2 activation. Despite no direct effect, MDP indirectly attenuates osteoclast differentiation through down-regulation of the RANKL/OPG ratio. MDP increases the expression of the MDP receptor, Nod2, and MDP-induced bone formation and osteoblast activation does not occur during Nod2-deficiency.
Increased bone and mineral density by enhanced bone formation are observed in mice administered with Muramyl dipeptide (MDP). Remarkably, pre-treatment or post-treatment with MDP alleviates bone loss in RANKL-induced osteoporosis mouse models.
|In vitro||DMSO||98 mg/mL (198.99 mM)|
|Water||98 mg/mL (198.99 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04888767||Not yet recruiting||Other: Interval Training Hight Intensity Program||Cystic Fibrosis||Fondation Ildys|Lille Catholic University||September 1 2021||Not Applicable|
|NCT04341753||Recruiting||Other: pulmonary rehabilitation||Chronic Obstructive Pulmonary Disease||University Hospital Brest||September 14 2020||Not Applicable|
|NCT04087590||Recruiting||Drug: Formoterol-glycopyrronium co suspension (PT003)||Copd||University Hospital Lille|AstraZeneca||January 14 2020||Phase 2|
|NCT04370990||Recruiting||Device: O2matic||COPD|Hypoxia|Closed-Loop Communication|Dyspnea|Anxiety|Depression||Copenhagen University Hospital Hvidovre||September 1 2019||Not Applicable|
|NCT04375917||Recruiting||Device: O2matic||COPD|Dyspnea|Anxiety|Depressive Symptoms|Hypoxia|Closed-Loop Communication||Copenhagen University Hospital Hvidovre||September 1 2019||Not Applicable|
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