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MS023 hydrochloride PRMT inhibitor

Name: MS023 hydrochloride
Brand: Selleck Chemicals
SKU: E2887
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E2887

MS023 hydrochloride(Compound 3) is a potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases (PRMT), with IC50 values of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

Chemical Structure

Molecular Weight: 396.78

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Quality Control

Batch: E288701 DMSO]57 mg/mL]false]Ethanol]57 mg/mL]false]Water]Insoluble]false Purity: 99.56%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.56

Related Targets	HDAC JAK BET Histone Methyltransferase PKC PARP HIF EZH2 AMPK Histone Acetyltransferase
Other PRMT Inhibitors	TNG908 (Ralometostat) GSK3326595 (Pemrametostat, EPZ015938) LLY-283 C7280948 GSK3368715 3HCl TC-E 5003 MRTX1719 (Navlimetostat) TP-064 BRD0639 Furamidine dihydrochloride

Solubility

In vitro
Batch:

DMSO : 57 mg/mL (143.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	396.78	Formula	C₁₇H₂₅N₃O.3ClH	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2108631-19-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	PRMT6 4 nM PRMT8 5 nM PRMT1 30 nM PRMT4 83 nM PRMT3 119 nM
References	[1] https://pubmed.ncbi.nlm.nih.gov/26598975/

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Handling Instructions

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