Montelukast

Catalog No.S5783 Synonyms: MK0476

For research use only.

Montelukast(MK0476) is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.

Montelukast Chemical Structure

CAS No. 158966-92-8

Selleck's Montelukast has been cited by 6 Publications

Purity & Quality Control

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Biological Activity

Description Montelukast(MK0476) is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 586.18
Formula

C35H36ClNO3S

CAS No. 158966-92-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04351698 Not yet recruiting Drug: Montelukast|Other: Oral Placebo Anemia Sickle Cell|Sleep-Disordered Breathing Great Ormond Street Hospital for Children NHS Foundation Trust|Guy''s and St Thomas'' NHS Foundation Trust|University College London Hospitals|North Middlesex University Hospital|King''s College Hospital NHS Trust|The Whittington Hospital NHS Trust March 30 2022 Phase 2|Phase 3
NCT05064631 Not yet recruiting Drug: Bacterial Lysate Respiratory Tract Infections|Pediatric ALL|Wheezing Queen Mary University of London|Queensland University of Technology November 19 2021 Phase 2
NCT03545997 Terminated Drug: Montelukast 10mg|Drug: Placebo Sleep Apnea Obstructive University Hospital Grenoble|Act For Chronic Diseases|Direction Générale de l''Offre de Soins November 29 2019 Phase 3
NCT03991988 Active not recruiting Drug: Montelukast|Drug: Placebo oral tablet Alzheimer Disease Emory University September 25 2019 Phase 2
NCT03898193 Completed Drug: Montelukast|Drug: Singulair Healthy Adults Pharmtechnology LLC|ClinPharmInvest LLC March 23 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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