ML 210

Catalog No.S0788 Synonyms: CID 49766530

For research use only.

ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.

ML 210 Chemical Structure

CAS No. 1360705-96-9

Selleck's ML 210 has been cited by 5 Publications

Purity & Quality Control

Choose Selective Peroxidases Inhibitors

Biological Activity

Description ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.
Targets
RAS [1] GPX4 [2]
(Cell-free assay)
0.04 μM(EC50)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BJeLR NX7ZPGRWS3m2b4TvfIlkcXS7IHHzd4F6 MmDhOFghcHK| M1XVR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJL\UyUIHPlcIx{KGW6cILld5NqdmdiSGLBV{BIOTKYIH31eIFvfCCjZoTldkA1QCCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUAxNjB5MTFOwG0v MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ7N{GwPUc,OjJ{OUexNFk9N2F-
BJ NEf1ZYpEgXSxdH;4bYNqfHliYYPzZZk> NUfBN4k1PDhiaILz M2niVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJLKGOnbHzzJIV5eHKnc4PpcochUFKDUzDHNVJXKG23dHHueEB4cXSqIHHseIVzdmG2aY\lJI9v[2:pZX7pZ{Bkd26|dIL1Z5R{KGGodHXyJFQ5KGi{czDifUBidGGvYYKgZox2\SCjc4PhfUwhUUN3MDC9JFAvOTB5IN88UU4> M{jLbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mkm3NVA6Lz5{MkK5O|ExQTxxYU6=
BJeH-LT MkjxR5l1d3SxeHnjbZR6KGG|c3H5 Mn7mOFghcHK| Mn7wR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmpmUC2OVDDj[YxteyCjZoTldkA1QCCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUAxNjJ5MjFOwG0v M1XBd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mkm3NVA6Lz5{MkK5O|ExQTxxYU6=
BJeH NUPGSoNtS3m2b4TvfIlkcXS7IHHzd4F6 MUO0PEBpenN? NXfid25rS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkqnSDDj[YxteyCjZoTldkA1QCCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUAxNjZ{ODFOwG0v MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ7N{GwPUc,OjJ{OUexNFk9N2F-

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 475.32
Formula

C22H20Cl2N4O4

CAS No. 1360705-96-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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