Mitiglinide Calcium

Synonyms: KAD-1229

Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

Mitiglinide Calcium Chemical Structure

Mitiglinide Calcium Chemical Structure

CAS No. 207844-01-7, 145525-41-3

Purity & Quality Control

Batch: S207301 Ethanol]2 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 99.90%
99.90

Mitiglinide Calcium Related Products

Biological Activity

Description Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
Targets
Potassium channel [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04349696 Completed
Type 2 Diabetes Mellitus|Liver Dysfunction
Orient Europharma Co. Ltd.
February 11 2014 Phase 4
NCT01403818 Completed
Healthy|Pharmacokinetics of ASP1941|Pharmacokinetics of Mitiglinide
Astellas Pharma Inc
June 2011 Phase 1
NCT00566865 Completed
Type 2 Diabetes Mellitus
Elixir Pharmaceuticals
November 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 668.88 Formula

(C19H24NO3)2.Ca

CAS No. 207844-01-7, 145525-41-3 SDF Download Mitiglinide Calcium SDF
Smiles C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].[Ca+2]
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 2 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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