Mirdametinib (PD0325901)

Name: Mirdametinib (PD0325901)
Brand: Selleck Chemicals
SKU: S1036
Rating: 5 (525 reviews)

For research use only.

Licensed by Pfizer Catalog No.S1036

525 publications

Mirdametinib (PD0325901) Chemical Structure

CAS No. 391210-10-9

Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.

Selleck's Mirdametinib (PD0325901) has been cited by 525 publications

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Nat Genet, 2020, 52(3):264-272

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Cell, 2019, 179(3):687-702

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Cell, 2019, 179(6):1276-1288

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Nat Med, 2019, 25(1):130-140

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Nature, 2018, 553(7686):96-100

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Cell, 2018, 174(2):406-421

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Nat Methods, 2018, 15(3):213-220

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Cancer Discov, 2018, 8(5):568-581

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Cell Stem Cell, 2018, 23(3):382-395

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Cell Stem Cell, 2018, 23(5):727-741

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Cell Stem Cell, 2017, 20(5):720-731

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Nature, 2016, 17;539(7629):452-455.

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Cancer Cell, 2016, 12;30(3):499-500

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Nature, 2015, 10.1038/nature14413

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Nature, 2015, 517(7534):391-5

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Cell, 2015, 160(1-2):161-76

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Cell, 2012, 21;151(5):937-50.

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Cell Stem Cell, 2012, 10(2):210-7

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Nat Methods , 2011, 8(6):487-93

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Cell Res, 2020, 30(1):21-33

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Sci Adv, 2020, 6(24):eaba0777

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Nucleic Acids Res, 2020, 10.1093/nar/gkaa067

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Elife, 2020, 9e60541

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Stem Cell Reports, 2020, 15(3):646-661

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Cancers (Basel), 2020, 27;12(5)pii: E1087

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Br J Cancer, 2020, 10.1038/s41416-020-0952-1

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FASEB J, 2020, 34(5):7178-7191

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Cancer Discov, 2020, 4;CD-20-0329

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Cancer Discov, 2020, 10(7):1058-1077

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Mol Cancer Ther, 2020, 19;molcanther10162019

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J Cancer, 2020, 11(15):4464-4473

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Oxid Med Cell Longev, 2020, 20;2020:3237150

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Am J Cancer Res, 2020, 10(1):148-163

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FEBS J, 2020, 287(1):122-144

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Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0669

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J Biol Chem, 2020, 10.1074/jbc.RA119.011837

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J Biol Chem, 2020, 295(3):673-689

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Endocrinology, 2020, 1;161(1) pii: bqz024

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Toxicol In Vitro, 2020, 5;66:104852

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Sci China Life Sci, 2020, 63(1):1-17

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Transl Oncol, 2020, 13(4):100751

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J Neurosci Methods, 2020, 330:108486

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Biochem Biophys Res Commun, 2020, 23;S0006-291X(20)30951-7

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Oral Dis, 2020, 10.1111/odi.13638

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Nucleic Acids Res, 2020, 10.1093

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Elife, 2020, 9:e56008

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Theriogenology, 2020, 146:58-70

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Theriogenology, 2020, 146:120-132

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Int J Immunopathol Pharmacol, 2020, Dec;34:2058738420909041

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Sci Rep, 2020, 10(1):13124

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Cell Rep, 2020, 30(2):510-524

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Nucleic Acids Res, 2020, 48(14):7856-7863

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Front Cell Dev Biol, 2020, 8:482

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Nat Chem Biol, 2020, 10.1038/s41589-020-0621-y

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J Vis Exp, 2020, (160)

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Nat Genet, 2020, 10.1038/s41588-020-0677-3

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EMBO Rep, 2020, e49863

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Cell Syst, 2020, S2405-4712(20)30247-7

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Nat Cell Biol, 2019, 21(7):824-834

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Nat Cell Biol, 2019, 21(11):1449-1461

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Mol Cell, 2019, S1097-2765(19)30838-X

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Nat Commun, 2019, 10(1):2532

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Nat Commun, 2019, 10(1):4481

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Mol Psychiatry, 2019, 10.1038/s41380-018-0325-9

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Nat Commun, 2019, 10(1):4349

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Nucleic Acids Res, 2019, 10.1093/nar/gkz482

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Sci Adv, 2019, 5(11):eaax7525

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Nucleic Acids Res, 2019, 47(3):1532-1543

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Genome Res, 2019, 29(10):1622-1634

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Proc Natl Acad Sci U S A, 2019, 116(26):12986-12995

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PLoS Biol, 2019, 17(3):e3000178

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Haematologica, 2019, 10.3324/haematol.2019.223024

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Cell Syst, 2019, 8(5):427-445

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Kidney Int, 2019, 96(4):927-941

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Cell Rep, 2019, 29(3):573-588

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Cell Rep, 2019, 28(8):2012-2022

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Elife, 2019, 10.7554/eLife.41627

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Int J Cancer, 2019, 145(3):748-762

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Stem Cell Reports, 2019,

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Stem Cell Reports, 2019, 13(3):485-498

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J Invest Dermatol, 2019, 139(9):2004-2015

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J Exp Clin Cancer Res, 2019, 38(1):463

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Cancers (Basel), 2019, 11(12)

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Pigment Cell Melanoma Res, 2019, 32(6):829-841

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Cell Death Dis, 2019, 10(3):171

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Cell Death Discov, 2019, 5:104

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Cell Chem Biol, 2019, 26(3):366-377

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Exp Mol Med, 2019, 51(11):135

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Front Immunol, 2019, 10:2020

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Cancer Discov, 2019, 10.1158/2159-8290.CD-19-0209

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Development, 2019, 146(14)

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Mol Cancer Ther, 2019, 18(3):642-655

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Mol Cancer Ther, 2019, 10.1158/1535-7163

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Aging (Albany NY), 2019, 11(22):10513-10531

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Carcinogenesis, 2019, 10.1093/carcin/bgz200

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Am J Cancer Res, 2019, 9(6):1282-1292

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Mol Cancer Res, 2019, 10.1158/1541-7786.MCR-19-0077

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Artif Cells Nanomed Biotechnol, 2019, 47(1):3231-3238

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J Nutr Biochem, 2019, 69:108-119

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J Cell Sci, 2019, 132(19)

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J Cell Mol Med, 2019, 10.1111/jcmm.14598

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J Cell Mol Med, 2019, 23(5):3629-3640

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Int J Mol Sci, 2019, 20(23)

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Sci Rep, 2019, 9(1):2195

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J Biol Chem, 2019, 294(47):17863-17874

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Endocrinology, 2019, 10.1210/endocr/bqz024

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Front Mol Neurosci, 2019, 12:212

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Breast Cancer Res Treat, 2019, 177(2):325-333

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CNS Neurosci Ther, 2019, 25(6):759-771

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Cancer Biol Ther, 2019, 20(1):21-30

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BMC Cancer, 2019, 19(1):485

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Cell Biosci, 2019, 9:60

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Transl Oncol, 2019, 12(7):932-950

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Eur J Pharmacol, 2019, 856:172409

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FEBS Lett, 2019, 593(16):2162-2176

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J Neurosci Methods, 2019, 330:108486

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PLoS One, 2019, 14(3):e0211134

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PLoS One, 2019, 14(5):e0216603

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DNA Cell Biol, 2019, 38(5):410-422

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J Biomater Appl, 2019, 33(10):1394-1406

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PeerJ, 2019, 10.7717/peerj.6314

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Biol Open, 2019, 8(11)

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Theriogenology, 2019, 10.1016/j.theriogenology.2019.11.022

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SLAS Technol, 2019, 24(1):28-40

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J Vis Exp, 2019, 10.3791/59826

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Nucleic Acids Res, 2019, 47(11):5670-5683

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Methods Mol Biol, 2019, 2005:101-124

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Oncotarget, 2019, 10(56):5755-5767

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Blood Adv, 2019, 3(21):3214-3227

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Nat Cell Biol, 2018, 20(4):400-412

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Nat Cell Biol, 2018, 20(11):1315-1325

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Nat Biomed Eng, 2018, 2(8):578-588

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Nat Chem Biol, 2018, 14(8):768-777

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Nat Struct Mol Biol, 2018, 25(9):766-777

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Nat Commun, 2018, 9(1):5078

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Nat Commun, 2018, 9(1):2819

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Nat Commun, 2018, 9(1):1463

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J Exp Med, 2018, 215(1):319-336

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EMBO Mol Med, 2018, 10(5)

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Clin Cancer Res, 2018, 24(10):2417-2429

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Dev Cell, 2018, 45(4):526-536

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Proc Natl Acad Sci U S A, 2018, 115(47):E11071-E11080

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Proc Natl Acad Sci U S A, 2018, 115(33):E7776-E7785

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Genes Dev, 2018, 32(5-6):448-461

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PLoS Biol, 2018, 16(9):e2006347

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PLoS Biol, 2018, 16(9):e2006624

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Cancer Res, 2018, 78(2):436-450

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Cell Syst, 2018, 6(6):664-678

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EMBO Rep, 2018, 19(8)

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Cancer Res, 2018, 78(19):5680-5693

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Cancer Res, 2018, 78(15):4396-4410

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Cell Rep, 2018, 24(2):489-502

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Cell Rep, 2018, 25(9):2563-2576

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Elife, 2018, 10.7554/eLife.31098

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Protein Cell, 2018, 9(8):717-728

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Oncogene, 2018, 37(31):4226-4238

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Stem Cell Reports, 2018, 10(2):477-493

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Stem Cell Reports, 2018, 11(2):593-606

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Sci Signal, 2018, 11(547)

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Cell Death Dis, 2018, 9(2):31

PubMed: 29348467 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):187

PubMed: 29416007 ( click the link to review the publication )

Cell Chem Biol, 2018, 25(6):705-717

PubMed: 29628435 ( click the link to review the publication )
Oncoimmunology, 2018, 7(9):e1480286

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Development, 2018, 145(18)

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Hum Mol Genet, 2018, 27(6):1093-1105

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J Immunol, 2018, 200(7):2372-2390

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Mol Cancer Res, 2018, 16(4):599-609

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Bone, 2018, 106:103-111

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J Cell Sci, 2018, 131(15)

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J Cell Sci, 2018, 131(18)

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J Cell Mol Med, 2018, 22(9):4221-4235

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Int J Mol Sci, 2018, 19(5)

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Int J Mol Sci, 2018, 19(12)

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Int J Mol Sci, 2018, 19(2)

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Sci Rep, 2018, 8(1):4111

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Sci Rep, 2018, 8(1):16170

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Sci Rep, 2018, 8(1):14344

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J Biol Chem, 2018, 293(14):5230-5235

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J Biol Chem, 2018, 293(30):11913-11927

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Inflamm Bowel Dis, 2018, 24(6):1251-1265

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Endocrinology, 2018, 159(8):2939-2952

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Mol Genet Metab, 2018, 123(4):518-525

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Cell Signal, 2018, 50:72-79

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Invest Ophthalmol Vis Sci, 2018, 59(1):462-471

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Stem Cells Dev, 2018, 27(21):1479-1493

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Stem Cells Dev, 2018, 27(10):692-703

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Cell Cycle, 2018, 17(5):535-549

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Cell Cycle, 2018, 17(12):1487-1495

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Am J Transl Res, 2018, 10(10):3068-3085

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PLoS One, 2018, 13(11):e0201683

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PLoS One, 2018, 13(2):e0191890

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Biochem Biophys Res Commun, 2018, 500(4):958-965

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Biol Open, 2018, 7(1)

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SLAS Discov, 2018, 23(2):132-143

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Mol Med Rep, 2018, 17(4):4999-5006

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Oncol Lett, 2018, 15(2):2604-2610

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Sci Rep, 2018, 8(1):4111

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Commun Biol, 2018, 1:158

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Oncotarget, 2018, 9(60):31572-31589

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NPJ Breast Cancer, 2018, 4:36

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NPJ Precis Oncol, 2018, 2(1):7

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Assay Drug Dev Technol, 2018, 16(7):408-419

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Methods Mol Biol, 2018, 1649:473-488

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Stem Cell Reports, 2018, 10(2):477-493

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Stem Cell Reports, 2018, 11(2):593-606

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Commun Biol, 2018, 1:158

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Cancer Res, 2013, 73(9):2873-83

PubMed: 23536552 ( click the link to review the publication )

Stem Cell Rep, 2013, 1(4):360-9

PubMed: 24319670 ( click the link to review the publication )

Cancer Discov, 2013, 3(5):520-33

PubMed: 23365119 ( click the link to review the publication )

Development, 2013, 140(14):2961-71

PubMed: 23760955 ( click the link to review the publication )

Development, 2013, 140(1):126-35

PubMed: 23175628 ( click the link to review the publication )

Mol Cancer Ther, 2013, 12(10):2213-25

PubMed: 23918833 ( click the link to review the publication )

Hum Mol Genet, 2013, 22(2):313-27

PubMed: 23077213 ( click the link to review the publication )

Mol Cancer Res, 2013, 11(12):1530-41

PubMed: 24152792 ( click the link to review the publication )

Bone, 2013, 59:151-61

PubMed: 24269278 ( click the link to review the publication )

Int J Mol Sci, 2013, 14(7):13748-62

PubMed: 23820584 ( click the link to review the publication )

Eur Cell Mater, 2013, 26:208-21

PubMed: 24146213 ( click the link to review the publication )

Stem Cells Dev, 2013, 22(1):114-23

PubMed: 22671711 ( click the link to review the publication )

Exp Cell Res, 2013, 319(19):2928-37

PubMed: 24080014 ( click the link to review the publication )

Exp Biol Med (Maywood), 2013, 238(3):276-84

PubMed: 23598973 ( click the link to review the publication )

PLoS One, 2013, 8(12):e81156

PubMed: 24339907 ( click the link to review the publication )

PLoS One, 2013, 8(2):e56518

PubMed: 23437152 ( click the link to review the publication )

Oncotarget, 2013, 4(12):2512-22

PubMed: 24318272 ( click the link to review the publication )

J Exp Med, 2012, 209(1):109-21

PubMed: 22213806 ( click the link to review the publication )
Cancer Res, 2012, 72(13):3350-9

PubMed: 22573716 ( click the link to review the publication )

Cancer Lett, 2012, 324(1):98-108

PubMed: 22579651 ( click the link to review the publication )

Sci Signal, 2012, 5(224):rs4

PubMed: 22589389 ( click the link to review the publication )

Stem Cells, 2012, 30(11):2423-36

PubMed: 22948967 ( click the link to review the publication )

Br J Haematol, 2012, 159(4):430-40

PubMed: 22985491 ( click the link to review the publication )

Radiother Oncol, 2012, 105(1):64-71

PubMed: 22682746 ( click the link to review the publication )

J Genet Genomics, 2012, 39(12):643-51

PubMed: 23273768 ( click the link to review the publication )

Cell Signal, 2012, 24(12):2360-8

PubMed: 22917534 ( click the link to review the publication )

Stem Cells Dev, 2012, 21(14):2606-12

PubMed: 22455749 ( click the link to review the publication )

Mol Cell, 2011, 43(5):723-37

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Oncogene, 2011, 30(11):1341-50

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J Bone Miner Res, 2011, 26(10):2486-97

PubMed: 21812026 ( click the link to review the publication )

Breast Cancer Res, 2011, 13(2):R36

PubMed: 21457548 ( click the link to review the publication )

Neoplasia, 2011, 13(2):154-66

PubMed: 21403841 ( click the link to review the publication )

Antiviral Res, 2011, 92(2):195-203

PubMed: 21854809 ( click the link to review the publication )

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PubMed: 21489997 ( click the link to review the publication )

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Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description

Targets

MEK ^[1]
(Cell-free assay)

0.33 nM

In vitro

PD0325901 shows higher permeability than CI-1040, another MEK inhibitor. PD0325901 should be able to achieve higher systemic exposures than CI-1040. ^[1] PD0325901 is exquisitely specific and highly potent against purified MEK, revealing a K_i^app of 1 nM against activated MEK1 and MEK2. ^[2] PD0325901 is roughly 500-fold more potent than CI-1040 with respect to its cellular effects on phosphorylation of ERK1 and ERK2, displaying subnanomolar activity. ^[2] PD0325901 prevents the growth of melanoma cell lines. PD0325901 inhibits the growth of TPC-1 cells and K2 cells with GI50 of 11 nM and 6.3 nM, respectively. ^[3] PD0325901 significantly prevents the the growth of PTC cells harboring a BRAF mutation at very low concentration (10 nM) and only moderately increases the growth of the PTC cells carrying the RET/PTC1 rearrangement at the same concentration. PD0325901 effectively inhibits the phosphorylation of ERK1/2 in multiple PTC cell lines. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human CHP-212 cell	M4PPdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NWLRZ\|dKUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNlEzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC53Mkegcm0v	Mm\oV2FPT0WU
human M14 cell	M2rOSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MorBTY5pcWKrdHnvckBw\iCqdX3hckBOOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkS1JI5ONg>?	NXXhW3ZWW0GQR1XS
human SK-MEL-28 cell	M1z4R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			Mlr1TY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRVytNlgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV{IH7NMi=>	MXrTRW5ITVJ?
human NOMO-1 cell	M4\lb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M4PnWWlvcGmkaYTpc44hd2ZiaIXtZY4hVk:PTz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPyCwTT6=	MmnhV2FPT0WU
human A375 cell	NUPwNGRCT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MVHJcohq[mm2aX;uJI9nKGi3bXHuJGE{PzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5JI5ONg>?	M2DPe3NCVkeHUh?=
human DU-4475 cell	NI\6RXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MWjJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTR2N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlU4KG6PLh?=	MWPTRW5ITVJ?
human C32 cell	MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NX3ZNoE1UW6qaXLpeIlwdiCxZjDoeY1idiCFM{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlY4KG6PLh?=	NH3wb\|hUSU6JRWK=
human BPH-1 cell	M3XDeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NU\mSGRoUW6qaXLpeIlwdiCxZjDoeY1idiCEUFitNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvQTVibl2u	M4j5N3NCVkeHUh?=
human CP50-MEL-B cell	M3vkWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M{fp[mlvcGmkaYTpc44hd2ZiaIXtZY4hS1B3MD3NSWwuSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTRwNUigcm0v	M4HGenNCVkeHUh?=
human H9 cell	NWH3dXhDT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NIn4SIJKdmirYnn0bY9vKG:oIHj1cYFvKEh7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;NT63O{BvVS5?	NXLnUo1xW0GQR1XS
human HTC-C3 cell	NF\lO2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NHnpeXlKdmirYnn0bY9vKG:oIHj1cYFvKEiWQz3DN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQDlibl2u	NXfOTHNGW0GQR1XS
human BHT-101 cell	M2jme2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MUPJcohq[mm2aX;uJI9nKGi3bXHuJGJJXC1zMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlchdk1w	MkjyV2FPT0WU
human COLO-741 cell	MlnzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MofuTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUe0NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOSCwTT6=	NXniRVBLW0GQR1XS
human OVCAR-5 cell	M{jmUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M3\6cWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDJibl2u	NW\NT\|NGW0GQR1XS
human A549 cell	M1zMVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M{D1emlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUeuPFkhdk1w	NWPS[GlFW0GQR1XS
human SH-4 cell growth	NWjqc3pTT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M2jlPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0hvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUiuNlYhdk1w	M2L3TXNCVkeHUh?=
human SK-N-AS cell	NHfRSmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M1vWV2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTj3BV{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPDRibl2u	NGXkSGZUSU6JRWK=
human HT-144 cell	NGPRU25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MmqyTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24Mlk4KG6PLh?=	MonGV2FPT0WU
human MEL-HO cell	MmroS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MXLJcohq[mm2aX;uJI9nKGi3bXHuJG1GVC2KTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUmuOFkhdk1w	NVfTWoJKW0GQR1XS
human COLO-679 cell	NXL3dHpOT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			Ml;0TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLU[3PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjBzIH7N	MYrTRW5ITVJ?
human HuP-T4 cell	NGLVPZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NHjDb3dKdmirYnn0bY9vKG:oIHj1cYFvKEi3UD3UOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjl6IH7NMi=>	NWrPOFV{W0GQR1XS
human H-EMC-SS cell	MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NVHLfnpTUW6qaXLpeIlwdiCxZjDoeY1idiCKLVXNR{1UWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFzLkCyJI5ONg>?	NHfpelhUSU6JRWK=
human LB2518-MEL cell	NX3I[\|hrT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MnTITY5pcWKrdHnvckBw\iCqdX3hckBNSjJ3MUitUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUOgcm0v	MYrTRW5ITVJ?
human HL-60 cell	MkTjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NHiyWZRKdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOTVibl2u	MkK4V2FPT0WU
human NCI-H1666 cell	NIHzRmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MYHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[2OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjF5IH7NMi=>	NIj0VGtUSU6JRWK=
human A101D cell	MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MoT3TY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGxMlQ2KG6PLh?=	MUnTRW5ITVJ?
human RVH-421 cell	M1XZSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHJXUC12MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk43PCCwTT6=	Ml;EV2FPT0WU
human Hs-578-T cell	NW\OSFNkT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NX7lZVlsUW6qaXLpeIlwdiCxZjDoeY1idiCKcz21O\|guXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTF{Lke5JI5ONg>?	MkDVV2FPT0WU
human A375 cells	M4TVTnBzd2yrZnXyZZRqd25iYYPzZZk>		MlP1O\|IhcA>?	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF\|N{WgZ4VtdHNiZYjwdoV{e2mwZzDCVmFHKFZ4MEDFJI12fGGwdDDh[pRmeiB5MjDodpMh[nliQ3XscEB1cXSncj3ncI8h[XO\|YYmsJGlEPTB;MUOgcm0v	MkLRNlM1PzR\|OEi=
human DOK cell	MnriS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NFv3R3hKdmirYnn0bY9vKG:oIHj1cYFvKESRSzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGzMlQhdk1w	MUDTRW5ITVJ?
human Mewo cell	NEjTNVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MmCyTY5pcWKrdHnvckBw\iCqdX3hckBO\XexIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MUSuOFUhdk1w	M1rQbXNCVkeHUh?=
human ONS-76 cell	NHHZcopIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M3Tz[mlvcGmkaYTpc44hd2ZiaIXtZY4hV06VLUe2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPTFibl2u	Mo\RV2FPT0WU
human UACC-257 cell	MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHVCS0NvMkW3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPjJibl2u	M2mxTnNCVkeHUh?=
human SW626 cell	NVPqPVExT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M1vYN2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d4Mk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE46OSCwTT6=	M2S4e3NCVkeHUh?=
human SW620 cell	NXzGZms{T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NGXQO\|VKdmirYnn0bY9vKG:oIHj1cYFvKFOZNkKwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvQTVibl2u	NVztfGxJW0GQR1XS
human TYK-nu cell	NUHWTGczT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHR[Uy2wdTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUG1MlE{KG6PLh?=	M1\GS3NCVkeHUh?=
human ACN cell	M2\RZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MWfJcohq[mm2aX;uJI9nKGi3bXHuJGFEViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTF3Lke2JI5ONg>?	MYfTRW5ITVJ?
human MIAPaCa2 cells	NXLTR\|ZPWHKxbHnm[ZJifGmxbjDhd5NigQ>?			Ml6xRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPSVHQZWNiOiClZXzsd{whUUN3ME2xO{BvVS5?	MlK5NlM1PzR\|OEi=
human T-24 cell	NVnrdHNIT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NHK0T5lKdmirYnn0bY9vKG:oIHj1cYFvKFRvMkSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPU44OSCwTT6=	Mly5V2FPT0WU
human AGS cell	NVTpPY1PT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MWjJcohq[mm2aX;uJI9nKGi3bXHuJGFIWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTJyLkSxJI5ONg>?	MkC1V2FPT0WU
human SW872 cell	M1TkR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MWDJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MkeuPVkhdk1w	MmT0V2FPT0WU
human C2BBe1 cell	NHTNWmNIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NInYOmNKdmirYnn0bY9vKG:oIHj1cYFvKEN{QlLlNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI5NjV2IH7NMi=>	M1KzfXNCVkeHUh?=
human MZ7-mel cell	MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MVzJcohq[mm2aX;uJI9nKGi3bXHuJG1bPy2vZXygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU41OyCwTT6=	NWT3R41OW0GQR1XS
human HCC2998 cell	MlP1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MmT2TY5pcWKrdHnvckBw\iCqdX3hckBJS0N{OUm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N\|MvPjZibl2u	NWjaPWxUW0GQR1XS
human HO-1-N-1 cell	MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NFnnW3hKdmirYnn0bY9vKG:oIHj1cYFvKEiRLUGtUk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwNEOgcm0v	NFvRO2NUSU6JRWK=
human SW756 cell	NEXQNYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NV\1S4lHUW6qaXLpeIlwdiCxZjDoeY1idiCVV{e1OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjR3IH7NMi=>	M{PDV3NCVkeHUh?=
human NCI-H1437 cell	M4nkV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NFvLdWNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQ{PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTN2LkS5JI5ONg>?	MXLTRW5ITVJ?
human NCI-H747 cell	NIHaTmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NETWbHBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO\|Q4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwOUigcm0v	NHL3dW9USU6JRWK=
human SK-MEL-2 cell	NH;KdohIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MlTKTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRVytNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM2NjJibl2u	MojLV2FPT0WU
human MZ2-MEL cell	MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG1bOi2PRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOU43PSCwTT6=	MUTTRW5ITVJ?
human PSN1 cell	NFnURVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MVrJcohq[mm2aX;uJI9nKGi3bXHuJHBUVjFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1\|OD60OUBvVQ>?	Mk\nV2FPT0WU
human CAL-39 cell	MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NYjMXpdtUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytN\|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{QS5yNDDuUU4>	MXXTRW5ITVJ?
human LOXIMVI cell	NEHMZ2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M3X6[GlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjN7IH7NMi=>	NVjZT2tEW0GQR1XS
human COLO-792 cell	MmjyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3;rSmlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz23PVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oy5zNTDuUU4>	NIPnTpZUSU6JRWK=
human CAL-27 cell	NEj3TVdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NUPDTVB[UW6qaXLpeIlwdiCxZjDoeY1idiCFQVytNlch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PC57MTDuUS=>	NEHscGpUSU6JRWK=
human AsPC-1 cell	MnvhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M{HV[mlvcGmkaYTpc44hd2ZiaIXtZY4hSXOSQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFUvOjhibl2u	NUW2XHhtW0GQR1XS
human NCI-H2291 cell	NFK0b25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			Mn7JTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKyPVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Pi52NjDuUU4>	MmD6V2FPT0WU
human RCM-1 cell	NEDRe2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M1G4eGlvcGmkaYTpc44hd2ZiaIXtZY4hWkOPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Ok45PSCwTT6=	MVfTRW5ITVJ?
human NCI-H292 cell	MoPsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MknCTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjN7IH7NMi=>	NEPNXm5USU6JRWK=
human WM-115 cell	NFfrRpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MlLtTY5pcWKrdHnvckBw\iCqdX3hckBYVS1zMUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20PE42KG6PLh?=	MYrTRW5ITVJ?
human RT-112 cell	MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NWPjU5UzUW6qaXLpeIlwdiCxZjDoeY1idiCUVD2xNVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01QC56NDDuUU4>	M{LHdnNCVkeHUh?=
human HT-29 cell	NHzhdW9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MmXFTY5pcWKrdHnvckBw\iCqdX3hckBJXC1{OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUWwMlQ6KG6PLh?=	NVPMe\|Y1W0GQR1XS
human RKO cell growth	MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NVvRSHRuUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Nk4xOiCwTT6=	NXXV[JpHW0GQR1XS
human KY821 cell	NWfBVXI2T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NHPSbGRKdmirYnn0bY9vKG:oIHj1cYFvKEu\OEKxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVMvOyCwTT6=	NUmwdYpjW0GQR1XS
human LB1047-RCC cell	NWq1bW5uT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M33MXWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTV7Lk[1JI5ONg>?	MmqyV2FPT0WU
human SW1116 cell	NIDuW5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NXfFb\|BwUW6qaXLpeIlwdiCxZjDoeY1idiCVV{GxNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03OC52OTDuUU4>	MkTQV2FPT0WU
human P12-ICHIKAWA cell	MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			Ml\ETY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Mj6yO{BvVS5?	MVzTRW5ITVJ?
human HCC70 cell	NHzjWmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M1S1UmlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22N{4xOSCwTT6=	M4\oZ3NCVkeHUh?=
human MIA-PaCa-2 cell	NVnYd3dJT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NWrzWJYxUW6qaXLpeIlwdiCxZjDoeY1idiCPSVGtVIFE[S1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;NkOuOVMhdk1w	MkLUV2FPT0WU
human LoVo cell	M4S0Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M3\NeGlvcGmkaYTpc44hd2ZiaIXtZY4hVG:YbzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPU[1MlI6KG6PLh?=	M3TzdXNCVkeHUh?=
human LB2241-RCC cell	M{PX[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MkDSTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PjVwNUKgcm0v	MnP3V2FPT0WU
human GAK cell	NFHsSYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NX3nS2FYUW6qaXLpeIlwdiCxZjDoeY1idiCJQVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Ok45PyCwTT6=	NGO0VpRUSU6JRWK=
human RD cell	NHvSPJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MVnJcohq[mm2aX;uJI9nKGi3bXHuJHJFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PjdwMTDuUU4>	Mn;xV2FPT0WU
human KNS-62 cell	NWSzZoVDT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NV\leYtzUW6qaXLpeIlwdiCxZjDoeY1idiCNTmOtOlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03QS57OTDuUU4>	MlPPV2FPT0WU
human HD-MY-Z cell	MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MUTJcohq[mm2aX;uJI9nKGi3bXHuJGhFNU2\LWqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23NU4yOiCwTT6=	NWK5XXRSW0GQR1XS
human COR-L105 cell	NXjmfFk2T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OMUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O\|EvPzFibl2u	NWLV[WZPW0GQR1XS
human IA-LM cell	NFGxVHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M1;KOWlvcGmkaYTpc44hd2ZiaIXtZY4hUUFvTF2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23N{4zQCCwTT6=	NFXH[pNUSU6JRWK=
human EM-2 cell	M2\Vfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MorTTY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;N{SuO{BvVS5?	MoH6V2FPT0WU
human NB69 cell	MkmwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MWrJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeR?=	NEPWOZlUSU6JRWK=
human HuP-T3 cell	M1Lt[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NYewUIhCUW6qaXLpeIlwdiCxZjDoeY1idiCKdWCtWFMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05Oy57MzDuUU4>	NHX3SI9USU6JRWK=
human BB30-HNC cell	M{TmNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MUjJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PFUvPTFibl2u	MYPTRW5ITVJ?
human HT-1080 cell	M2iwUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NGGyNIhKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGwPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05PS56ODDuUU4>	NIjMNoFUSU6JRWK=
human RMG-I cell	M4f0XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M2DqcmlvcGmkaYTpc44hd2ZiaIXtZY4hWk2JLVmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24O{4{PCCwTT6=	M3XSWnNCVkeHUh?=
human HCC1419 cell	NFj0fGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NFnLVpFKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{G0NVkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06OS5\|ODDuUU4>	MXrTRW5ITVJ?
human SW780 cell	NGXxblJIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M2TReGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25Nk4{OiCwTT6=	MWHTRW5ITVJ?
human SNU-387 cell	NYPpc\|JpT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MmXOTY5pcWKrdHnvckBw\iCqdX3hckBUVlVvM{i3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PVMvOzZibl2=	MWjTRW5ITVJ?
human LAMA-84 cell	MmHBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NFztb4tKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06PC54ODDuUU4>	NFOyUW1USU6JRWK=
human MV-4-11 cell	M4fBdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MmnkTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PVQvPzNibl2u	M{nQbnNCVkeHUh?=
human EGI-1 cell	MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NIi0enFKdmirYnn0bY9vKG:oIHj1cYFvKEWJST2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PVUvQDFibl2u	NX;ybllRW0GQR1XS
human NCI-SNU-1 cell	MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NXzodVJtUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17Nj63N{BvVS5?	MUjTRW5ITVJ?
human MEG-01 cell	NHuwTINIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NETQemNKdmirYnn0bY9vKG:oIHj1cYFvKE2HRz2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVk4Njd5IH7NMi=>	NX\Hb\|g4W0GQR1XS
human OMC-1 cell	MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MVTJcohq[mm2aX;uJI9nKGi3bXHuJG9OSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MUCwMlI{KG6PLh?=	MWDTRW5ITVJ?
human NB10 cell	NUHtR\|hZT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M4W2cmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGwNE41OiCwTT6=	MkDnV2FPT0WU
human CAL-62 cell	Mk\TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			Mm\CTY5pcWKrdHnvckBw\iCqdX3hckBESUxvNkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNFAvPzhibl2u	MX3TRW5ITVJ?
human NCI-H2087 cell	NWL4e41DT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NX;sbFVrUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQDdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMEGuNVQhdk1w	NITYcZRUSU6JRWK=
human MDA-MB-175-VII cell	NEG3V\|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M13yUGlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVE4PS2YSVmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfS=>	NVy3cnN6W0GQR1XS
human LS-513 cell	NGDFZ2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MkTrTY5pcWKrdHnvckBw\iCqdX3hckBNWy13MUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNVQvQDNibl2u	NY\iOYd[W0GQR1XS
human HN cell growth	MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MkXsTY5pcWKrdHnvckBw\iCqdX3hckBJViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTF{Mj61PUBvVS5?	Mm\uV2FPT0WU
human ABC-1 cell	MlPlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MVnJcohq[mm2aX;uJI9nKGi3bXHuJGFDSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MUKzMlAzKG6PLh?=	MlHYV2FPT0WU
human SJSA-1 cell	MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MVTJcohq[mm2aX;uJI9nKGi3bXHuJHNLW0FvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGyN{4yQSCwTT6=	NYKxVlNxW0GQR1XS
human PANC1 cells	M1PmemZ2dmO2aX;uJIF{e2G7	NXPKR4lZOTBizszN	MYCxJIg>	Ml7ITY5pcWKrdHnvckBw\iCPRVuxJIlvKGi3bXHuJHBCVkNzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBxTXKtMT:yJIxmfmWuIHH0JFExKHWPIHHmeIVzKDFiaIKgZpkhX2W\|dHXyckBjdG:2dHnu[{BidmGueYPpdy=>	MWOyOVc3PjZ\|Mx?=
human MCF7 cells	M4i4VmZ2dmO2aX;uJIF{e2G7		NV3RenFqPzVibXnudy=>	MnnYTY5pcWKrdHnvckBw\iCPRXuxM\|IhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKGGodHXyJFc2KG2rboOgZpkhX2W\|dHXyckBjdG:2dHnu[{BidmGueYPpdy=>	Mk\6NlM{QTh2NUO=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ERK / p-AKT / Cyclin D1 / p27; PubMed: 22573716 Cancer Res parental or MEK inhibitor-resistant clonal populations (1182, 1183, and 1187) were treated with increasing doses of PD0325901 for 24 hours and subjected to immunoblot analysis using the indicated antibodies. p-p70S6K(T389) / p4EBP1(S65) / pS6(S235); PubMed: 27699948 Cancer Sci Sensitive (MKN-45, OKAJIMA, HSC-57, GUS, NUGC-4, OCUM-1, SNU-719, and IM95) and resistant (SH-10-TC, MKN-1, HSC-39, NCI-N87, H-111-TC, KE-97, SNU-484, and TMK-1) cell lines were treated with DMSO or PD0325901 (0.1 or 1 μM) for 24 h and then subjected to Western blotting using antibodies against pERK, pAKT, p-p70S6K, p4EBP1, pS6, and GAPDH. cleaved PARP; PubMed: 22573716 Cancer Res NF1-deficient U251 or LN229 GBM cells were treated with PD0325901 for 4 days and subjected to immunoblot analysis using the indicated antibodies. DR5; PubMed: 25867065 Oncogene The indicated cancer cell lines were exposed to the given concentrations of the inhibitors as indicated for 16 h.	22573716 27699948 25867065
Immunofluorescence	Fibronectin / Actin / pFAK; PubMed: 28187762 BMC Cancer Representative immunofluorescence images of FNMA by GBM-3 cells treated either with DMSO (b) or PD0325901 (c). Fibronectin is depicted in green and DAPI (blue) was used as counterstain. PD0325901 did not appear to induce FNMA by GBM-3 cells. Rhodamine-phalloidin staining of actin in DMSO-treated (d) or PD0325901-treated GBM-3 cells (e). Note significant cell shape change and actin fiber organization. Scale bar in (e) is 5 μm. Triple stain for actin (red), p-FAK (green) and DAPI (blue) in DMSO-treated (f) and PD0325901-treated (g) GBM-3 cells. PD0325901 appears to induce the localization of p-FAK at sites of cell-ECM attachment. Thirty-micron thick z-stack of DMSO (h) and PD0325901-treated (i) collected by confocal microscopy of multicellular aggregates of GBM-3. Note marked change in actin organization from cortical to stress fibers. Scale bar in (i) is 30 μm. ZO-1; PubMed: 25394671 EMBO Rep 16HBE cells were fixed and stained for ZO-1 and DNA. Scale bar, 20 μm.	28187762 25394671

In vivo

The improved potency of PD0325901 relative to CI-1040 is evident. A single oral dose of PD0325901 (25 mg/kg) inhibits phosphorylation of ERK by more than 50% at 24 hours post-dosing. In contrast, CI-1040 at a much higher dose (150 mg/kg) only inhibit pERK levels for roughly 8 hours, returning to control levels by 24 hours after treatment. ^[2] Therefore, the dose required to produce a 70% incidence of complete tumor responses (C26 model) is 25 mg/kg/day versus 900 mg/kg/day for PD0325901 and CI-1040, respectively. Anticancer activity of PD 0325901 has been demonstrated for a broad spectrum of human tumor xenografts. ^[2] After 1 week of oral administration of PD0325901 (20–25 mg/kg/day) in mice, no tumor growth is detected in mice inoculated with PTC cells bearing a BRAF mutation. ^[3] For PTC with the RET/PTC1 rearrangement, the average tumor volume of the orthotopic tumor is decreased by 58% as compared with controls. In conclusion, PTC cells carrying a BRAF mutation are more sensitive to PD0325901 than are PTC cells carrying the RET/PTC1 rearrangement. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse In vitro cascade assay: Incorporation of ³²P into myelin basic protein (MBP) is assayed in the presence of a glutathione S-transferase fusion protein containing p44MAP kinase (GST-MAPK) and a glutathione S-transferase protein containing p45MEK (GST-MEK). The assay solution contained 20 mM HEPES, pH 7.4, 10 mM MgCl₂, 1 mM MnCl₂, 1 mM EGTA, 50 mM [gamma-³²P]ATP, 10 mg GST-MEK, 0.5 mg GST-MAPK and 40 mg MBP in a final volume of 100 mL. Reactions are stopped after 20 minutes by addition of trichloroacetic acid and filtered through a GF/C filter mat. ³²P retained on the filter mat is determined using a 1205 Betaplate. PD0325901 is assessed at various dose ranges in order to determine dose response curves.
Cell Research: ^[3]	- Collapse Cell lines: PTC cells Concentrations: 0.1 nM- 1 μM Incubation Time: 48 hours Method: PTC cells (1 × 10⁴) are seeded in 24-well plates with 1 mL of medium for 4 days in a 37 °C incubator. MEK inhibitor PD0325901 at varying concentrations is added to the cells in triplicate on day 0. MTT dissolved in 0.8% NaCl solution at 5 mg/mL is added to each well (0.2 mL) on day 2 to test GI50 or every day for cell growth curves. The cells are incubated at 37 °C for 3 hours with MTT. The liquid is then aspirated from the wells and discarded. Stained cells are dissolved in 0.5 mL of DMSO and their absorption at 570 nm is measured using a Synergy HT multidetection microplate reader. For GI50, cell growth is calculated as 100 × (T − T₀)/(C − T₀), where T is the optical density of the wells treated with inhibitors after a 48-hour period, T₀ is the optical density at time zero, and C is the control optical density with DMSO only. (Only for Reference)
Animal Research: ^[3]	- Collapse Animal Models: Ncr-nu/nu mice bearing PTC cells Dosages: 20-25 mg/kg Administration: Oral gavage (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	96 mg/mL (199.09 mM)
	Water	Insoluble
	Ethanol	'40 mg/mL
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Mirdametinib (PD0325901) SDF

Molecular Weight	482.19
Formula	C₁₆H₁₄F₃IN₂O₄
CAS No.	391210-10-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
Whether the inhibitor PD0325901 interacts with other targets other than MEK?
Answer:
PD0325901 has very high selectivity to MEK. In addition, it can also inhibits VEGF activity according to the reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713590/

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Selective MEK Inhibitor

Selumetinib (AZD6244) : MEK1-selective, IC50=14 nM.
FDA-approved MEK Inhibitor

Trametinib (GSK1120212) : Approved by FDA against BRAF V600E mutated metastatic melanoma.
Newest MEK Inhibitor

Binimetinib (MEK162, ARRY-162, ARRY-438162) : Potent inhibitor of MEK1/2 with IC50 of 12 nM.
Classic MEK Inhibitor

SL-327 : Water soluble MEK1/2 inhibitor, which can cross the blood-brain barrier.

Related MEK Products

Cobimetinib (GDC-0973) ^New

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.
BI-847325 ^New

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
GDC-0623 ^New

GDC-0623 (G-868) is a potent and ATP-uncompetitive MEK1 inhibitor with K_i of 0.13 nM. Phase 1.
Trametinib (GSK1120212)

Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.

Features:More potent than PD0325901 or AZD6244.
Selumetinib (AZD6244)

Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.

Features:First MEK inhibitor being tested in Phase II clinical trials.
U0126-EtOH

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.

Features:A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2.
PD98059

PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.

Features:Does not inhibit c-Raf phosphorylated MEK1.
PD184352 (CI-1040)

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis. Phase 2.

Features:First MEK inhibitor to begin clinical development.
Binimetinib (MEK162)

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.
Refametinib (RDEA119)

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

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Mirdametinib (PD0325901)