PD0325901

Licensed by Pfizer Catalog No.S1036

Molecular Weight(MW): 482.19

PD0325901 is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.

Cited by 164 Publications

Nat Med, 2019, 25(1):130-140

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Nature, 2018, 553(7686):96-100

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Cell, 2018, 174(2):406-421

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Cell Stem Cell, 2018, 23(3):382-395

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Cell Stem Cell, 2018, 23(5):727-741

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Cancer Cell, 2018, 33(6):985-1003

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Cell Stem Cell, 2017, 20(5):720-731

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Cancer Cell, 2017, 32(6):748-760

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Nature, 2016, 539(7629):452-455

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Nature, 2015, 10.1038/nature14413

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Nature, 2015, 517(7534):391-5

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Cell, 2015, 160(1-2):161-76

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Cell, 2012, 151(5):937-50

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Cell Stem Cell, 2012, 10(2):210-7

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Nat Methods , 2011, 8(6):487-93

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Mol Psychiatry, 2019, 10.1038/s41380-018-0325-9

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Nucleic Acids Res, 2019, 10.1093/nar/gkz482

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PLoS Biol, 2019, 17(3):e3000178

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Elife, 2019, 10.7554/eLife.41627

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Cell Death Discov, 2019, 5:104

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Development, 2019, 146(14)

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Mol Cancer Ther, 2019, 18(3):642-655

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Mol Cancer Ther, 2019, 10.1158/1535-7163

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Mol Cancer Res, 2019, 10.1158/1541-7786.MCR-19-0077

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J Cell Mol Med, 2019, 10.1111/jcmm.14598

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J Cell Mol Med, 2019, 23(5):3629-3640

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Sci Rep, 2019, 9(1):2195

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CNS Neurosci Ther, 2019, 25(6):759-771

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BMC Cancer, 2019, 19(1):485

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Eur J Pharmacol, 2019, 856:172409

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PLoS One, 2019, 14(3):e0211134

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DNA Cell Biol, 2019, 38(5):410-422

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PeerJ, 2019, 10.7717/peerj.6314

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Methods Mol Biol, 2019, 2005:101-124

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Nat Commun, 2018, 9(1):5078

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Clin Cancer Res, 2018, 24(10):2417-2429

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Clin Cancer Res, 2018, 24(19):4771-4784

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Dev Cell, 2018, 45(4):526-536

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Cancer Res, 2018, 78(2):436-450

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Cell Rep, 2018, 25(9):2563-2576

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J Immunol, 2018, 200(7):2372-2390

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Int J Mol Sci, 2018, 19(2)

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J Biol Chem, 2018, 293(14):5230-5235

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J Biol Chem, 2018, 293(30):11913-11927

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Invest Ophthalmol Vis Sci, 2018, 59(1):462-471

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Stem Cells Dev, 2018, 27(21):1479-1493

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Cell Cycle, 2018, 17(5):535-549

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Cell Cycle, 2018, 17(12):1487-1495

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Biochem Biophys Res Commun, 2018, 500(4):958-965

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Mol Med Rep, 2018, 17(4):4999-5006

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Methods Mol Biol, 2018, 1649:473-488

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Blood, 2017, 129(12):1691-1701

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Nat Protoc, 2017, 12(10):2097-2109

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Nat Commun, 2017, 8(1):672

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Clin Cancer Res, 2017, 23(21):6567-6579

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Dev Cell, 2017, 41(3):274-286

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Cancer Res, 2017, 77(7):1599-1610

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Cell Rep, 2017, 18(13):3167-3177

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Stem Cells Transl Med, 2017, 6(2):340-351

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Mol Cell Neurosci, 2017, 82:66-75

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PLoS One, 2017, 12(4):e0176120

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PLoS One, 2017, 12(8):e0183343

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Methods Mol Biol, 2017, 1487:163-174

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Oncotarget, 2017, 8(24):39460-39475

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Oncotarget, 2017, 8(20):32977-32989

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Oncotarget, 2017, 8(29):47574-47585

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Cell, 2017, 168(3):473-486

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Oncotarget, 2017, 9(1):249-267

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Proc Natl Acad Sci U S A, 2016, 113(44):12478-12483

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Cell Death Differ, 2016, 23(3):430-41

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J Exp Clin Cancer Res, 2016, 35:68

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FASEB J, 2016, 31(3):1046-1058

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Mol Pharm, 2016, 13(11):3724-3735

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Int J Oncol, 2016, 49(6):2236-2244

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Cell Tissue Res, 2016, 364(2):429-41

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FEBS Lett, 2016, 590(19):3416-3424

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PLoS One, 2016, 11(1):e0147682

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PLoS One, 2016, 11(7):e0158655

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PLoS One, 2016, 11(6):e0158046

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J Surg Res, 2016, 206(2):371-379

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J Vet Med Sci, 2016, 78(4):709-13

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Tumour Biol, 2016, 37(4):4767-76

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Methods Mol Biol, 2016, 1480:153-65

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EMBO Rep, 2015, 16(1):87-96

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Oncogene, 2015, 10.1038/onc.2015.97

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J Neurosci, 2015, 35(9):3893-902

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FASEB J, 2015, 10.1096/fj.14-267278

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Stem Cells, 2015, 33(3):686-98

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Stem Cells, 2015, 33(11):3228-38

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Stem Cells, 2015, 10.1002/stem.1990

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Stem Cells, 2015, 33(3):686-98

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Mol Cancer Ther, 2015, 14(1):298-306

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J Thromb Haemost, 2015, 10.1111/jth.12954

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Am J Cancer Res, 2015, 5(4):1507-18

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Int J Biol Sci, 2015, 11(4):411-422

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Biomed Pharmacother, 2015, 75:40-50

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J Dermatol Sci, 2015, 78(1):44-50

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Int J Oncol, 2015, 47(1):71-80

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Exp Cell Res, 2015, 335(2):197-206

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Int J Biochem Cell Biol, 2015, 60C:34-42

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Biol Reprod, 2015, 10.1095/biolreprod.114.127647

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PLoS One, 2015, 10(3):e0120396

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PLoS One, 2015, 10(3):e0119387

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J Reprod Dev, 2015, 61(5):473-84

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Cell Biology International Reports, 2015, 10.1002/cbi3.10019

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Nature, 2015, 521(7551):232-6

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Blood, 2014, 123(18):2838-42

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J Exp Med, 2014, 211(3):395-404

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Clin Cancer Res, 2014, 20(9):2410-23

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Proc Natl Acad Sci USA, 2014, 111(29):10678-83

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Proc Natl Acad Sci USA, 2014, 10.1073/pnas.1319738111

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Kidney Int, 2014, 10.1038/ki.2014.107

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Oncogene, 2014, 33(14):1828-39

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Cancer Lett, 2014, 347(2):212-24

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Mol Cancer Ther, 2014, 13(8):2073-80

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Mol Cancer Ther, 2014, 13(12):3098-106

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J Bone Joint Surg Am, 2014, 96(14):e117

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J Immunol, 2014, 192(4):1351-5

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J Biol Chem, 2014, 10.1074/jbc.M114.580076

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Cell Signal, 2014, 26(10):2276-2283

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Stem Cells Dev, 2014, 23(17):2030-45

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Biol Reprod, 2014, 91(4):88

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Pancreas, 2014, 43(1):88-92

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PLoS One, 2014, 9(4):e92304

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PLoS One, 2014, 9(1):e85089

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Theriogenology, 2014, 82(2):283-93

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Mol Med Rep, 2014, 10.3892/mmr.2014.2793

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Oncotarget, 2014, 5(23):12189-202

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Oncotarget, 2014, 5(2):351-62.

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Blood, 2013, 122,215045

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Proc Natl Acad Sci USA, 2013, 110(10):4015-20

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Cancer Res, 2013, 73(9):2873-83

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Stem Cell Rep, 2013, 1(4):360-9

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Development, 2013, 140(14):2961-71

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Mol Cancer Ther, 2013, 12(10):2213-25

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Bone, 2013, 59:151-61

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Eur Cell Mater, 2013, 26:208-21

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Stem Cells Dev, 2013, 22(1):114-23

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Exp Cell Res, 2013, 319(19):2928-37

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Exp Biol Med (Maywood), 2013, 238(3):276-84

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PLoS One, 2013, 8(12):e81156

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PLoS One, 2013, 8(2):e56518

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Cancer Res, 2012, 72(13):3350-9

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Cancer Lett, 2012, 324(1):98-108

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Sci Signal, 2012, 5(224):rs4

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Stem Cells, 2012, 30(11):2423-36

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Br J Haematol, 2012, 159(4):430-40

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Radiother Oncol, 2012, 105(1):64-71

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J Genet Genomics, 2012, 39(12):643-51

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Cell Signal, 2012, 24(12):2360-8

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Stem Cells Dev, 2012, 21(14):2606-12

PubMed: 22455749 ( click the link to review the publication )

Mol Cell, 2011, 43(5):723-37

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Oncogene, 2011, 30(11):1341-50

PubMed: 21057530 ( click the link to review the publication )

J Bone Miner Res, 2011, 26(10):2486-97

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Breast Cancer Res, 2011, 13(2):R36

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Neoplasia, 2011, 13(2):154-66

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Antiviral Res, 2011, 92(2):195-203

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J Biol Chem, 2011, 286(24):21062-72

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Pharm Res, 2011, 28(12):3069-78

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PLoS One, 2011, 6(10):e26755

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Sci Signal, 2010, 3(149):ra84

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J Biol Chem, 2010, 285(42):32370-7

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Genes Cancer, 2010, 1(10):994-1007

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Cancer Res, 2009, 69(17):6839-47

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Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Description

Targets

MEK ^[1]
(Cell-free assay)

0.33 nM

In vitro

PD0325901 shows higher permeability than CI-1040, another MEK inhibitor. PD0325901 should be able to achieve higher systemic exposures than CI-1040. ^[1] PD0325901 is exquisitely specific and highly potent against purified MEK, revealing a K_i^app of 1 nM against activated MEK1 and MEK2. ^[2] PD0325901 is roughly 500-fold more potent than CI-1040 with respect to its cellular effects on phosphorylation of ERK1 and ERK2, displaying subnanomolar activity. ^[2] PD0325901 prevents the growth of melanoma cell lines. PD0325901 inhibits the growth of TPC-1 cells and K2 cells with GI50 of 11 nM and 6.3 nM, respectively. ^[3] PD0325901 significantly prevents the the growth of PTC cells harboring a BRAF mutation at very low concentration (10 nM) and only moderately increases the growth of the PTC cells carrying the RET/PTC1 rearrangement at the same concentration. PD0325901 effectively inhibits the phosphorylation of ERK1/2 in multiple PTC cell lines. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human CHP-212 cell	MlWzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MnzITY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42Ojdibl2u	MX;TRW5ITVJ?
human M14 cell	M3u0WGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MWPJcohq[mm2aX;uJI9nKGi3bXHuJG0yPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwNEWgcm0v	NXvIXWpmW0GQR1XS
human SK-MEL-28 cell	NHXie\|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2HTD2yPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTJibl2u	MVzTRW5ITVJ?
human NOMO-1 cell	NFXHNohIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NFLFdGJKdmirYnn0bY9vKG:oIHj1cYFvKE6RTV:tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODdibl2u	M{DhcXNCVkeHUh?=
human A375 cell	M3v1Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			Mn;MTY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;Mj62PUBvVS5?	MlHRV2FPT0WU
human DU-4475 cell	MoLwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MlHXTY5pcWKrdHnvckBw\iCqdX3hckBFXS12NEe1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42PyCwTT6=	NEDBbnpUSU6JRWK=
human C32 cell	NXnmToRIT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MWfJcohq[mm2aX;uJI9nKGi3bXHuJGM{OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTNwNkegcm0v	MkLWV2FPT0WU
human BPH-1 cell	MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MkjTTY5pcWKrdHnvckBw\iCqdX3hckBDWEhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUOuPVUhdk1w	Mn3SV2FPT0WU
human CP50-MEL-B cell	NXrnVVR5T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M2nsR2lvcGmkaYTpc44hd2ZiaIXtZY4hS1B3MD3NSWwuSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTRwNUigcm0v	NU[xO2Y6W0GQR1XS
human H9 cell	MmjpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NXLZS2tHUW6qaXLpeIlwdiCxZjDoeY1idiCKOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUWuO\|chdk1w	NGD2WWpUSU6JRWK=
human HTC-C3 cell	M2HWZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M4j2W2lvcGmkaYTpc44hd2ZiaIXtZY4hUFSFLVOzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45QSCwTT6=	MWfTRW5ITVJ?
human BHT-101 cell	MorRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M4nzfWlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPyCwTT6=	Mn:xV2FPT0WU
human COLO-741 cell	NXXjWI5ET3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NWG4XJJPUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVc1OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTdwMTDuUU4>	MVLTRW5ITVJ?
human OVCAR-5 cell	NUPJeXVwT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M1HmZWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDJibl2u	MkPsV2FPT0WU
human A549 cell	MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M4HZfmlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUeuPFkhdk1w	NGfK[XpUSU6JRWK=
human SH-4 cell growth	M1;zeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NHr0eoZKdmirYnn0bY9vKG:oIHj1cYFvKFOKLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlI3KG6PLh?=	NFPXSFZUSU6JRWK=
human SK-N-AS cell	MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NIf0codKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tRXMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjR2IH7NMi=>	MkXJV2FPT0WU
human HT-144 cell	MlHwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NWrDS4tpUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05Njl5IH7NMi=>	NXHPbZBoW0GQR1XS
human MEL-HO cell	MmPMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3TC[mlvcGmkaYTpc44hd2ZiaIXtZY4hVUWOLVjPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU41QSCwTT6=	NEjGRWFUSU6JRWK=
human COLO-679 cell	M{fMR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MkTBTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLU[3PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjBzIH7N	M2j6e3NCVkeHUh?=
human HuP-T4 cell	NXXi[GFHT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M2HtOGlvcGmkaYTpc44hd2ZiaIXtZY4hUHWSLWS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQThibl2u	MlPzV2FPT0WU
human H-EMC-SS cell	Mn;US5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3y4OGlvcGmkaYTpc44hd2ZiaIXtZY4hUC2HTVOtV3Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5yMjDuUU4>	NGfyNY9USU6JRWK=
human LB2518-MEL cell	M4rW[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M2exNmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFzLkGzJI5ONg>?	NXjrRVBGW0GQR1XS
human HL-60 cell	NGLlVHFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M3PxS2lvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4yPSCwTT6=	M2PLfnNCVkeHUh?=
human NCI-H1666 cell	MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M4[1SGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlY3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUegcm0v	NYTEdINtW0GQR1XS
human A101D cell	MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M{DYb2lvcGmkaYTpc44hd2ZiaIXtZY4hSTFyMVSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU41PSCwTT6=	M1:2VHNCVkeHUh?=
human RVH-421 cell	MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NYrHSoU2UW6qaXLpeIlwdiCxZjDoeY1idiCUVlitOFIyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwNkSgcm0v	MmPJV2FPT0WU
human Hs-578-T cell	NEGwUm1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NFfzRVVKdmirYnn0bY9vKG:oIHj1cYFvKEi\|LUW3PE1VKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwN{mgcm0v	MUTTRW5ITVJ?
human A375 cells	MnzzVJJwdGmoZYLheIlwdiCjc4PhfS=>		MVS3NkBp	NF;ifG5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGzO\|Uh[2WubIOg[ZhxemW\|c3nu[{BDWkGIIG[2NFBGKG23dHHueEBi\nSncjC3NkBpenNiYomgR4VtdCC2aYTldk1odG9iYYPzZZktKEmFNUC9NVMhdk1w	MUeyN\|Q4PDN6OB?=
human DOK cell	NYXLc4ZET3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NV7EXJd5UW6qaXLpeIlwdiCxZjDoeY1idiCGT1ugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{41KG6PLh?=	NVzIdWI{W0GQR1XS
human Mewo cell	NFnvUY9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M4XidWlvcGmkaYTpc44hd2ZiaIXtZY4hVWW5bzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUG0MlQ2KG6PLh?=	MnLIV2FPT0WU
human ONS-76 cell	NEDHcItIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MXTJcohq[mm2aX;uJI9nKGi3bXHuJG9PWy15NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUG0MlUyKG6PLh?=	MmnVV2FPT0WU
human UACC-257 cell	Mm\iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NVPQO4ZbUW6qaXLpeIlwdiCxZjDoeY1idiCXQVPDMVI2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTF2Lk[yJI5ONg>?	MnT0V2FPT0WU
human SW626 cell	NWTIb2pCT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M1zue2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d4Mk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE46OSCwTT6=	NYfXVZk3W0GQR1XS
human SW620 cell	NHXVd3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M{PMRmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4MkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE46PSCwTT6=	Mlu0V2FPT0WU
human TYK-nu cell	MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MkDyTY5pcWKrdHnvckBw\iCqdX3hckBVYUtvboWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOyCwTT6=	NIPCeItUSU6JRWK=
human ACN cell	MnnXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M1e1RWlvcGmkaYTpc44hd2ZiaIXtZY4hSUOQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MUWuO\|Yhdk1w	NY[3WXd[W0GQR1XS
human MIAPaCa2 cells	MYPQdo9tcW[ncnH0bY9vKGG\|c3H5			NXnGWXlpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNTWFR[UOjMjDj[YxteyxiSVO1NF0yPyCwTT6=	M2\STVI{PDd2M{i4
human T-24 cell	M3\5Zmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NV3R[nNOUW6qaXLpeIlwdiCxZjDoeY1idiCWLUK0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVkvPzFibl2u	NWLwT\|J[W0GQR1XS
human AGS cell	M1zaUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NInLcIFKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUKwMlQyKG6PLh?=	MnvsV2FPT0WU
human SW872 cell	MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M3rtcmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yO{46QSCwTT6=	NWrNS5hNW0GQR1XS
human C2BBe1 cell	MnjmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M4PtR2lvcGmkaYTpc44hd2ZiaIXtZY4hSzKEQnWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvPTRibl2u	MoPvV2FPT0WU
human MZ7-mel cell	MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			Mnz5TY5pcWKrdHnvckBw\iCqdX3hckBOYjdvbXXsJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvPDNibl2u	NIDIWJNUSU6JRWK=
human HCC2998 cell	MlnCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NGPmRmFKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{K5PVgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oy54NjDuUU4>	NGq2SJdUSU6JRWK=
human HO-1-N-1 cell	M1;h[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MWrJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N\|QvPDNibl2u	NUPlTGtWW0GQR1XS
human SW756 cell	NEPVeplIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MoDCTY5pcWKrdHnvckBw\iCqdX3hckBUXzd3NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUO0MlQ2KG6PLh?=	NUPJT4Q4W0GQR1XS
human NCI-H1437 cell	MmHpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NFvqVWtKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQ{PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTN2LkS5JI5ONg>?	NH7rbFhUSU6JRWK=
human NCI-H747 cell	MkmxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MlPnTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEe0O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1Njl6IH7NMi=>	NV\nUmlMW0GQR1XS
human SK-MEL-2 cell	MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NXn6TY5EUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTN3LkKgcm0v	MXXTRW5ITVJ?
human MZ2-MEL cell	MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NHzOPW1KdmirYnn0bY9vKG:oIHj1cYFvKE2cMj3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PS54NTDuUU4>	MWDTRW5ITVJ?
human PSN1 cell	NVPEXG9OT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NX72THRwUW6qaXLpeIlwdiCxZjDoeY1idiCSU16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N\|gvPDVibl2=	NInEfXFUSU6JRWK=
human CAL-39 cell	NYDacXAzT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NGTMdXFKdmirYnn0bY9vKG:oIHj1cYFvKEODTD2zPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjB2IH7NMi=>	M3\qSHNCVkeHUh?=
human LOXIMVI cell	MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NGW0PWhKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{QS5\|OTDuUU4>	M{\jenNCVkeHUh?=
human COLO-792 cell	NFLEW3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NIfB[lRKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tO\|kzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDNwMUWgcm0v	NFywSHRUSU6JRWK=
human CAL-27 cell	MoD3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M4XmbWlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUK3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFQvQTFibl2=	NGmxXXlUSU6JRWK=
human AsPC-1 cell	NHeyR4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NWLlSnNJUW6qaXLpeIlwdiCxZjDoeY1idiCDc2DDMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PS5{ODDuUU4>	M12zeHNCVkeHUh?=
human NCI-H2291 cell	MlXkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MUnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkK5NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ3NjR4IH7NMi=>	NGftPXRUSU6JRWK=
human RCM-1 cell	M32zS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MlLvTY5pcWKrdHnvckBw\iCqdX3hckBTS01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUS2Mlg2KG6PLh?=	NUW1T21vW0GQR1XS
human NCI-H292 cell	MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NIn2c2FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDdwM{mgcm0v	MorrV2FPT0WU
human WM-115 cell	MoTuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHdONTFzNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUS4MlUhdk1w	NF23U5pUSU6JRWK=
human RT-112 cell	MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NGfh[HdKdmirYnn0bY9vKG:oIHj1cYFvKFKWLUGxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ5Njh2IH7NMi=>	MVHTRW5ITVJ?
human HT-29 cell	MmXXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NXz0OpVEUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2yPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUxNjR7IH7NMi=>	NG\DNWNUSU6JRWK=
human RKO cell growth	NVvDSFRJT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NHrGO2FKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUWyMlAzKG6PLh?=	NUjsdHhoW0GQR1XS
human KY821 cell	NX7ydFAzT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M4TDb2lvcGmkaYTpc44hd2ZiaIXtZY4hU1l6MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21N{4{KG6PLh?=	M{Hue3NCVkeHUh?=
human LB1047-RCC cell	Ml[1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M4\BZ2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTV7Lk[1JI5ONg>?	Mnm4V2FPT0WU
human SW1116 cell	M3Xjcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MYHJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPU[wMlQ6KG6PLh?=	NEnN[GtUSU6JRWK=
human P12-ICHIKAWA cell	MmLxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M{T2PWlvcGmkaYTpc44hd2ZiaIXtZY4hWDF{LVnDTGlMSVeDIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;NkKuNlchdk1w	Mk\5V2FPT0WU
human HCC70 cell	MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NIrIXGRKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{ewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OlMvODFibl2u	NGTJTpdUSU6JRWK=
human MIA-PaCa-2 cell	MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MXHJcohq[mm2aX;uJI9nKGi3bXHuJG1KSS2SYVPhMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03Oy53MzDuUU4>	MlT1V2FPT0WU
human LoVo cell	M3XtcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NGq0THFKdmirYnn0bY9vKG:oIHj1cYFvKEyxVn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22OU4zQSCwTT6=	NHrWbodUSU6JRWK=
human LB2241-RCC cell	NX6wT2tWT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03PS53MjDuUU4>	MWHTRW5ITVJ?
human GAK cell	MmDZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MkPpTY5pcWKrdHnvckBw\iCqdX3hckBISUtiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Nj64O{BvVS5?	M{i0TnNCVkeHUh?=
human RD cell	NEW2emlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MljITY5pcWKrdHnvckBw\iCqdX3hckBTTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTZ5LkGgcm0v	MVXTRW5ITVJ?
human KNS-62 cell	NFv6ZlFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MnTmTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvNkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22PU46QSCwTT6=	NYfpSGU3W0GQR1XS
human HD-MY-Z cell	NE\5bY9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M1raXmlvcGmkaYTpc44hd2ZiaIXtZY4hUERvTWmtXkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcyNjF{IH7NMi=>	MlmyV2FPT0WU
human COR-L105 cell	MkXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M1zlXWlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVyxNFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04OS55MTDuUU4>	NWnLO5RjW0GQR1XS
human IA-LM cell	MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MVrJcohq[mm2aX;uJI9nKGi3bXHuJGlCNUyPIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;N{OuNlghdk1w	NFT6UGVUSU6JRWK=
human EM-2 cell	MkjsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NUHBVopRUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O\|QvPyCwTT6=	Ml;TV2FPT0WU
human NB69 cell	NILJXFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M1j4PWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5	NHHNUVNUSU6JRWK=
human HuP-T3 cell	NVz4fZhjT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M3q4d2lvcGmkaYTpc44hd2ZiaIXtZY4hUHWSLWSzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PFMvQTNibl2u	MnTVV2FPT0WU
human BB30-HNC cell	NVXpbIVCT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NHrqNnFKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QDVwNUGgcm0v	MWTTRW5ITVJ?
human HT-1080 cell	MmrPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MmXSTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zMEiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PFUvQDhibl2u	M3rI[3NCVkeHUh?=
human RMG-I cell	M2jG[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M4fZd2lvcGmkaYTpc44hd2ZiaIXtZY4hWk2JLVmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24O{4{PCCwTT6=	NEDTSZRUSU6JRWK=
human HCC1419 cell	NHnwbYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGhESzF2MUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25NU4{QCCwTT6=	MnzlV2FPT0WU
human SW780 cell	NGSzOItIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NXfsdoN6UW6qaXLpeIlwdiCxZjDoeY1idiCVV{e4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkzNjN{IH7NMi=>	MljnV2FPT0WU
human SNU-387 cell	MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NHfTSotKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT2zPFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06Oy5\|NjDuUS=>	NUHrSlhNW0GQR1XS
human LAMA-84 cell	MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MmHhTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PVQvPjhibl2u	MljnV2FPT0WU
human MV-4-11 cell	NHrEdJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NGXTN2FKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06PC55MzDuUU4>	M{OyUnNCVkeHUh?=
human EGI-1 cell	NYLYVJRET3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NE\NUWZKdmirYnn0bY9vKG:oIHj1cYFvKEWJST2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PVUvQDFibl2u	NVrUTXI6W0GQR1XS
human NCI-SNU-1 cell	M1ziO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NViyeYl{UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17Nj63N{BvVS5?	NGDscolUSU6JRWK=
human MEG-01 cell	NIPONYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MVnJcohq[mm2aX;uJI9nKGi3bXHuJG1GTy1yMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUm3Mlc4KG6PLh?=	MVHTRW5ITVJ?
human OMC-1 cell	Mnq4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M1XPVmlvcGmkaYTpc44hd2ZiaIXtZY4hV02FLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNFAvOjNibl2u	Ml3BV2FPT0WU
human NB10 cell	MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NGj3N3VKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNFAvPDJibl2u	M17nN3NCVkeHUh?=
human CAL-62 cell	Mn3DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NXzDeVBOUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yODBwN{igcm0v	NHfaZ5FUSU6JRWK=
human NCI-H2087 cell	Mo[wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NHj5dIdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA5PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFyMT6xOEBvVS5?	M3\WS3NCVkeHUh?=
human MDA-MB-175-VII cell	M2jSV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NVPMeItSUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTd3LW\JTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6	MlTHV2FPT0WU
human LS-513 cell	NW\0TGN1T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MWPJcohq[mm2aX;uJI9nKGi3bXHuJGxUNTVzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGxOE45OyCwTT6=	NUD0eJY5W0GQR1XS
human HN cell growth	NHHDOpRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			Mo\QTY5pcWKrdHnvckBw\iCqdX3hckBJViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTF{Mj61PUBvVS5?	NWH5Nm9JW0GQR1XS
human ABC-1 cell	Ml3wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M4jLVWlvcGmkaYTpc44hd2ZiaIXtZY4hSUKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNlMvODJibl2u	M2PEOXNCVkeHUh?=
human SJSA-1 cell	M3PIWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NWTSOIo1UW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOjNwMUmgcm0v	NWLy[XF1W0GQR1XS
human PANC1 cells	M2S3[2Z2dmO2aX;uJIF{e2G7	MkCyNVAh\|ryP	NX;qeG9YOSCq	MVHJcohq[mm2aX;uJI9nKE2HS{GgbY4hcHWvYX6gVGFPSzFiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJBGemtzL{KgcIV3\WxiYYSgNVAhfU1iYX\0[ZIhOSCqcjDifUBY\XO2ZYLuJIJtd3S2aX7nJIFv[Wy7c3nz	M4S4VVI2PzZ4NkOz
human MCF7 cells	MkG3SpVv[3Srb36gZZN{[Xl?		MVq3OUBucW6\|	NVHsfYhEUW6qaXLpeIlwdiCxZjDNSYsyNzJiaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIHHmeIVzKDd3IH3pcpMh[nliV3XzeIVzdiCkbH;0eIlv\yCjbnHsfZNqew>?	M1LQOFI{Ozl6NEWz

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ERK / p-AKT / Cyclin D1 / p27; PubMed: 22573716 Cancer Res parental or MEK inhibitor-resistant clonal populations (1182, 1183, and 1187) were treated with increasing doses of PD0325901 for 24 hours and subjected to immunoblot analysis using the indicated antibodies. p-p70S6K(T389) / p4EBP1(S65) / pS6(S235); PubMed: 27699948 Cancer Sci Sensitive (MKN-45, OKAJIMA, HSC-57, GUS, NUGC-4, OCUM-1, SNU-719, and IM95) and resistant (SH-10-TC, MKN-1, HSC-39, NCI-N87, H-111-TC, KE-97, SNU-484, and TMK-1) cell lines were treated with DMSO or PD0325901 (0.1 or 1 μM) for 24 h and then subjected to Western blotting using antibodies against pERK, pAKT, p-p70S6K, p4EBP1, pS6, and GAPDH. cleaved PARP; PubMed: 22573716 Cancer Res NF1-deficient U251 or LN229 GBM cells were treated with PD0325901 for 4 days and subjected to immunoblot analysis using the indicated antibodies. DR5; PubMed: 25867065 Oncogene The indicated cancer cell lines were exposed to the given concentrations of the inhibitors as indicated for 16 h.	22573716 27699948 25867065
Immunofluorescence	Fibronectin / Actin / pFAK; PubMed: 28187762 BMC Cancer Representative immunofluorescence images of FNMA by GBM-3 cells treated either with DMSO (b) or PD0325901 (c). Fibronectin is depicted in green and DAPI (blue) was used as counterstain. PD0325901 did not appear to induce FNMA by GBM-3 cells. Rhodamine-phalloidin staining of actin in DMSO-treated (d) or PD0325901-treated GBM-3 cells (e). Note significant cell shape change and actin fiber organization. Scale bar in (e) is 5 μm. Triple stain for actin (red), p-FAK (green) and DAPI (blue) in DMSO-treated (f) and PD0325901-treated (g) GBM-3 cells. PD0325901 appears to induce the localization of p-FAK at sites of cell-ECM attachment. Thirty-micron thick z-stack of DMSO (h) and PD0325901-treated (i) collected by confocal microscopy of multicellular aggregates of GBM-3. Note marked change in actin organization from cortical to stress fibers. Scale bar in (i) is 30 μm. ZO-1; PubMed: 25394671 EMBO Rep 16HBE cells were fixed and stained for ZO-1 and DNA. Scale bar, 20 μm.	28187762 25394671

In vivo

The improved potency of PD0325901 relative to CI-1040 is evident. A single oral dose of PD0325901 (25 mg/kg) inhibits phosphorylation of ERK by more than 50% at 24 hours post-dosing. In contrast, CI-1040 at a much higher dose (150 mg/kg) only inhibit pERK levels for roughly 8 hours, returning to control levels by 24 hours after treatment. ^[2] Therefore, the dose required to produce a 70% incidence of complete tumor responses (C26 model) is 25 mg/kg/day versus 900 mg/kg/day for PD0325901 and CI-1040, respectively. Anticancer activity of PD 0325901 has been demonstrated for a broad spectrum of human tumor xenografts. ^[2] After 1 week of oral administration of PD0325901 (20–25 mg/kg/day) in mice, no tumor growth is detected in mice inoculated with PTC cells bearing a BRAF mutation. ^[3] For PTC with the RET/PTC1 rearrangement, the average tumor volume of the orthotopic tumor is decreased by 58% as compared with controls. In conclusion, PTC cells carrying a BRAF mutation are more sensitive to PD0325901 than are PTC cells carrying the RET/PTC1 rearrangement. ^[3]

Protocol

Kinase Assay: ^[1]	+ Expand In vitro cascade assay: Incorporation of ³²P into myelin basic protein (MBP) is assayed in the presence of a glutathione S-transferase fusion protein containing p44MAP kinase (GST-MAPK) and a glutathione S-transferase protein containing p45MEK (GST-MEK). The assay solution contained 20 mM HEPES, pH 7.4, 10 mM MgCl₂, 1 mM MnCl₂, 1 mM EGTA, 50 mM [gamma-³²P]ATP, 10 mg GST-MEK, 0.5 mg GST-MAPK and 40 mg MBP in a final volume of 100 mL. Reactions are stopped after 20 minutes by addition of trichloroacetic acid and filtered through a GF/C filter mat. ³²P retained on the filter mat is determined using a 1205 Betaplate. PD0325901 is assessed at various dose ranges in order to determine dose response curves.
Cell Research: ^[3]	+ Expand Cell lines: PTC cells Concentrations: 0.1 nM- 1 μM Incubation Time: 48 hours Method: PTC cells (1 × 10⁴) are seeded in 24-well plates with 1 mL of medium for 4 days in a 37 °C incubator. MEK inhibitor PD0325901 at varying concentrations is added to the cells in triplicate on day 0. MTT dissolved in 0.8% NaCl solution at 5 mg/mL is added to each well (0.2 mL) on day 2 to test GI50 or every day for cell growth curves. The cells are incubated at 37 °C for 3 hours with MTT. The liquid is then aspirated from the wells and discarded. Stained cells are dissolved in 0.5 mL of DMSO and their absorption at 570 nm is measured using a Synergy HT multidetection microplate reader. For GI50, cell growth is calculated as 100 × (T − T₀)/(C − T₀), where T is the optical density of the wells treated with inhibitors after a 48-hour period, T₀ is the optical density at time zero, and C is the control optical density with DMSO only. (Only for Reference)
Animal Research: ^[3]	+ Expand Animal Models: Ncr-nu/nu mice bearing PTC cells Formulation: 80 mM citric buffer (pH 7) Dosages: 20-25 mg/kg Administration: Oral gavage (Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	96 mg/mL (199.09 mM)
	Ethanol	40 mg/mL (82.95 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PD0325901 SDF

Molecular Weight	482.19
Formula	C₁₆H₁₄F₃IN₂O₄
CAS No.	391210-10-9
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
Whether the inhibitor PD0325901 interacts with other targets other than MEK?
Answer:
PD0325901 has very high selectivity to MEK. In addition, it can also inhibits VEGF activity according to the reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713590/

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Selective MEK Inhibitor

Selumetinib (AZD6244) : MEK1-selective, IC50=14 nM.
FDA-approved MEK Inhibitor

Trametinib (GSK1120212) : Approved by FDA against BRAF V600E mutated metastatic melanoma.
Newest MEK Inhibitor

Binimetinib (MEK162, ARRY-162, ARRY-438162) : Potent inhibitor of MEK1/2 with IC50 of 12 nM.
Classic MEK Inhibitor

SL-327 : Water soluble MEK1/2 inhibitor, which can cross the blood-brain barrier.

Related MEK Products

Cobimetinib (GDC-0973, RG7420) ^New

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Phase 3.
BI-847325 ^New

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
GDC-0623 ^New

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with K_i of 0.13 nM. Phase 1.
Trametinib (GSK1120212)

Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

Features:More potent than PD0325901 or AZD6244.
Selumetinib (AZD6244)

Selumetinib (AZD6244) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Phase 3.

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U0126-EtOH

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.

Features:A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2.
PD98059

PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2.

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PD184352 (CI-1040)

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Features:First MEK inhibitor to begin clinical development.
Binimetinib (MEK162, ARRY-162, ARRY-438162)

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.
Refametinib (RDEA119, Bay 86-9766)

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

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PD0325901

Cited by 164 Publications

Purity & Quality Control

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Protocol

References

Solubility (25°C)

Chemical Information Download PD0325901 SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

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Total Molecular Weight: g/mol

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Frequently Asked Questions

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Related MEK Products

Choose Your Country or Region

By Signaling Pathways

By product type

PD0325901

Cited by 164 Publications

Purity & Quality Control

Choose Selective MEK Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download PD0325901 SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

MEK Signaling Pathway Map

MEK Inhibitors with Unique Features

Related MEK Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)