Home Cell Cycle CDK inhibitor M2N12 For research use only.

M2N12

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM, also shows promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM, respectively.

M2N12 Chemical Structure

M2N12 Chemical Structure

CAS: 2376577-06-7

Purity & Quality Control

Batch: E264001 DMSO] 10 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.57%
99.57

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Biological Activity

Description M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM, also shows promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM, respectively.
Targets
Cdc25C [1]
(in enzyme inhibition assay)		 Cdc25A [1]
(in enzyme inhibition assay)		 Cdc25B [1]
(in enzyme inhibition assay)
0.09 μM 0.53 μM 1.39 μM

Chemical Information & Solubility

Molecular Weight 393.83 Formula

C20H16ClN5O2
CAS No. 2376577-06-7 SDF --
Smiles CC1=CC=C(C[N]2C=C(CNC3=C(Cl)C(=O)C4=CC=CN=C4C3=O)N=N2)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (25.39 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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