Name: MPP+ iodide
Brand: Selleck Chemicals
SKU: S6301
Rating: 5 (1 reviews)

MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.

MPP+ iodide Chemical Structure

CAS: 36913-39-0

Selleck's MPP+ iodide has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.98%

99.98

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Biological Activity

Description

MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.

Targets

DAT ^[1]	SERT ^[1]

In vitro
In vitro	Vacuolin-1 potently and reversibly inhibits the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagosomes. Vacuolin-1 activates RAB5A to block autophagosome-lysosome fusion. ^[1]
Cell Research	Cell lines	HeLa cells
	Concentrations	1 μM
	Incubation Time	10 min, 2 h
	Method	The active RAB5A in cells treated with vacuoin-1 or transfected with RAB5A-CA or RAB5A-DN are examined by a GST-tagged RABEP1 affinity isolation assay.

In Vivo
In vivo	MPP+ iodide decreases mitochondrial oxidation-reduction activity and membrane potential in rat striatum.
Animal Research	Animal Models	Male Wistar rats
	Dosages	40 nM
	Administration	intrastriatal infusion

References

Chemical Information & Solubility

Molecular Weight	297.13	Formula	C₁₂H₁₂IN
CAS No.	36913-39-0	SDF	--
Smiles	[I-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2
Storage (From the date of receipt)	3 years-20°C(in the dark) powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°C(in the dark) powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 72 mg/mL ( (242.31 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : 35 mg/mL

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In vivo
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