MPP+ iodide

For research use only.

Catalog No.S6301 Synonyms: N-Methyl-4-Phenylpyridinium Iodide

MPP+ iodide Chemical Structure

CAS No. 36913-39-0

MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.

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Description MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
Targets
DAT [1]
()
SERT [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 72 mg/mL (242.31 mM)
Water Insoluble
Ethanol '72 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 297.13
Formula

C12H12IN

CAS No. 36913-39-0
Storage powder
in solvent
Synonyms N-Methyl-4-Phenylpyridinium Iodide

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID