Motolimod (VTX-2337)

For research use only.

Catalog No.S7161

8 publications

Motolimod (VTX-2337) Chemical Structure

CAS No. 926927-61-9

Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.

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Description Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.
TLR8 [1]
100 nM(EC50)
In vitro

VTX-2337 stimulates the production of both TNFα with EC50 of 140 nM and IL-12 with EC50 of 120 nM in PBMCs. In monocytes and mDCs, VTX-2337 selectively induces the production of TNFα and IL-12 via NF-κB activation. VTX-2337 also stimulates IFNγ production from NK cells, augments the lytic function of NK cells and enhances ADCC. [1]

In vivo In an ovarian cancer mouse model, TX-2337 enhances the effect of pegylated liposomal doxorubicin (PLD). [2]


Kinase Assay:[1]
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Activity assay:

The activity of specific TLR agonists is assessed using the secretory embryonic alkaline phosphatase (SEAP) reporter gene that is linked to NF-κB activation in response to TLR stimulation. Measurement of SEAP activity using the Quanti-blue substrate (InvivoGen) after TLR agonist treatment is carried out.
Cell Research:[1]
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  • Cell lines: PBMCs or purified NK cells
  • Concentrations: ~500 nM
  • Incubation Time: 48 h
  • Method: PBMCs or purified NK cells are prepared as previously described, and the purity of NK cells was approximately 99%. NK cell–mediated cytotoxicity is assessed by Calcein AM release from labeled target cells. In brief, PBMCs or purified NK cells are cultured for 48 hours in RPMI medium in the presence of VTX-2337 (167 or 500 nmol/L) before incubation with target cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 55 mg/mL warmed (119.93 mM)
Ethanol 15 mg/mL (32.7 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.6


CAS No. 926927-61-9
Storage powder
in solvent
Synonyms N/A
Smiles CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03906526 Recruiting Drug: VTX-2337|Drug: Nivolumab Carcinoma Squamous Cell Celgene July 3 2019 Phase 1
NCT01289210 Terminated Drug: VTX-2337 plus radiotherapy Low Grade B Cell Lymphoma Celgene|Stanford University July 2011 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID