Catalog No.S7809 Synonyms: CP-456773
Molecular Weight(MW): 426.46
MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Cited by 9 Publications
4 Customer Reviews
A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
ARTHRITIS & RHEUMATOLOGY, 2017, 69(8):1636-1646. MCC950(CP-456773) purchased from Selleck.
Cells were pretreated with the indicated concentrations of MCC950 followed by incubation with APAP (2mM) for additional 18 h. Cell viability was determined by MTS assay. The data are presented as the fold change compared with APAP-treated cells and expressed as mean ± SEM (n = 3).
Biochem Pharmacol, 2018, 154:278-292. MCC950(CP-456773) purchased from Selleck.
Representative lung tissue sections stained by HE with or without Mcc950 treatment.
Biochem Biophys Res Commun, 2018, 503(4):3031-3037. MCC950(CP-456773) purchased from Selleck.
a, b Effects of varying MCC950 concentrations (0,1,10,50 and 100 μmol/L) on NLRP3 and Caspase-1 expression within the high glucose group. The protein was measured by western blotting.GAPDH was used as an internal loading control. NG:normal control group,HG:high glucose group.Data are presented in mean ± SD, □P < 0. 05 versus normal control group, △P < 0. 05 versus high glucose group.
BMC Complement Altern Med, 2018, 18(1):192. MCC950(CP-456773) purchased from Selleck.
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|Description||MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.|
MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.
|In vivo||MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. |
|In vitro||Water||85 mg/mL (199.31 mM)|
|Ethanol||40 mg/mL (93.79 mM)|
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