MCC950 Sodium (CP-456773 Sodium)

For research use only.

Catalog No.S7809 Synonyms: CRID3 sodium salt

81 publications

MCC950 Sodium (CP-456773 Sodium) Chemical Structure

CAS No. 256373-96-3

MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.

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Selleck's MCC950 Sodium (CP-456773 Sodium) has been cited by 81 publications

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Choose Selective NLRP3 Inhibitors

Biological Activity

Description MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
NLRP3 [1]
(in BMDM (bone marrow derived macrophages))
NLRP3 [1]
(in HMDM)
7.5nM 8.1 nM
In vitro

MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse BMDM cells M4PwUmZ2dmO2aX;uJIF{e2G7 NXjxb4NoOzBibXnudy=> MlP5TY5pcWKrdHnvckBw\iCQTGLQN{BqdiCvb4Xz[UBDVUSPIHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOzBibXnud{Bnd2yub4fl[EBjgSCDVGCgZYRlcXSrb36gZpkhTUyLU1GgZY5idHm|aYOuJGlEPTB;MD6wNFc2KM7:TR?= Ml\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MkKwNFYoRjJ4NEKyNFA3RC:jPh?=
mouse BMDM cells MofmSpVv[3Srb36gZZN{[Xl? MoDtN|AhdWmwcx?= NWS1Zmd4UW6qaXLpeIlwdiCxZjDOUHJROyCrbn\sZY1u[XOxbXWgZYN1cX[jdHnvckBqdiCOUGOtd5RqdXWuYYTl[EBud3W|ZTDCUWROKGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBPVFKSMzDpcoZt[W2vYYPvcYUucW6mdXPl[EBKVC1zYnX0ZUBxem:mdXP0bY9vKHC{ZXnuZ5Vj[XSnZDDmc5IhOzBibXnud{Bnd2yub4fl[EBjgSCQTGLQN{B{fGmvdXzheIlwdiC5aYToJGFVWCCkeTDFUGlUSS5iSVO1NF0xNjByN{Wg{txO NHfOXIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m5OFc{Oyd-Mke5PVQ4OzN:L3G+
INS-1 cells NInKOYlHfW6ldHnvckBie3OjeR?= M1fiWlAvODFizszN M2n4TlEhcA>? NV;ENnFsVUOFOUWwJIlvcGmkaYTl[EBvd3Rib37sfUBqdm[uYX3tZZNwdWViYXP0bZZifGmxbjDieZQh[Wy|bzDBcochUUlvaX7keYNm\CCLTD2x{tIh\WyndnH0bY9vKGGwZDDj[YxtKGGyb4D0c5NqeyCrbjDJUnMuOSClZXzsd{4> M4HrXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUO5NVkzLz5|MEmzPVE6OjxxYU6=
16HBE cells NYfLOoR[S2WubDD2bYFjcWyrdImgZZN{[Xl? MXqwMlAyNCByLkGsJFEtKDFyLDCxNFAh|ryP NEH2UoMzPCxiNEisJFczcA>? NYjiZlFUOTByzszNJG1ESzl3MDDmeY5kfGmxbnHscJkh[WyuZY\pZZRm\CC|aXzpZ4EucW6mdXPl[EBi[3SrdnH0bY9vKG:oIF7MVnA{KGmwZnzhcY1ie2:vZTDpckAyPiCKQlWgZ4VtdHNw NWnjO|FpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyOVg4PDZpPkK5NlU5PzR4PD;hQi=>
THP-1 monocytes M335fGZ2dmO2aX;uJIF{e2G7 NFvIe3YyKM7:TR?= MoLxN|AhdWmwcx?= NEjzXZlRemW2cnXheI1mdnRib3[gWGhR6oDSMTDtc45w[3m2ZYOg[o9zKDNyIH3pckB4cXSqIITobZMh[2:vcH;1coQhemW|dXz0[YQhcW5iYTDzbYdvcW[rY3HueEBz\WS3Y4Tpc44hcW5iSV|ihLAy|rJicnXs[YF{\SxiYoX0JI5wfCCyeYLvdJRwe2m|IIXwc44hfHKjboPm[YN1cW:wIIfpeIghVFCVLh?= NIrXd2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG3N|k5QCd-Mk[xO|M6QDh:L3G+
macrophages NXrFclg1TnWwY4Tpc44h[XO|YYm= NWfaWY03OzBibXnudy=> Mnu1TY5pcWKrdHnvckBw\iCQTGLQN{BqdiCqdX3hckBud26xY4n0[UBl\XKrdnXkJI1i[3KxcHjh[4V{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBNWFNvaX7keYNm\CCLTD2xZoV1[SCycn;keYN1cW:wIHnuZ5Vj[XSnZDDmc5IhOzBibXnud{Bnd2yub4fl[EBjgSCwaXfldolkcW5ic3;kbZVuKHOjbISgd5RqdXWuYYTpc44h\m:{IEKgbJJ{KHCxc4SgUHBUKGOqYXzs[Y5o\SCob4KgN{BpenNiYomgSWxKW0FuIFnDOVAhRSByLkCwOUDPxE1w MmTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|M{i5NVAoRjJ7M{O4PVExRC:jPh?=
macrophages NI\QeFdHfW6ldHnvckBie3OjeR?= M33j[mlvcGmkaYTpc44hd2ZiTlzSVFMhcW5iaIXtZY4hdW:wb3P5eIUh\GW{aY\l[EBu[WO{b4DoZYdmeyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hVFCVLXnu[JVk\WRiSVytNYJmfGFicILv[JVkfGmxbjDifUBGVEmVQTygTWM2OCB;IECuNFA5KM7:TT6= NITJNpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzPFkyOCd-MkmzN|g6OTB:L3G+

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
NLRP3 / Casp-1 / BMI1 / ALDH1 / CD44; 

PubMed: 28865486     

The expression of NLRP3 inflammasome, BMI1, ALDH1 and CD44 was analyzed by Western blot after treatment with LPS + ATP (6 h) and MCC950(12 h) in CAL27.

Growth inhibition assay
Cell viability; 

PubMed: 27670879     

Cell viability from unprimed WT and Card9−/− BMDMs infected with S. Typhimurium at m.o.i. 10 for 2 and 6 h in presence or absence of NLRP3 inhibitors MCC950.

ALDH1 / BIM1 / CD44; 

PubMed: 28865486     

CAL27 cells were treated with LPS + ATP(6 h) and 10, 25, and 50 nM MCC950 (12 h). The cells were analyzed by immunofluorescence cytochemistry. ALDH1 (green), BMI1 and CD44 (red), DAPI (blue); Scale bar = 50 μm.


PubMed: 28726778     

Concentration-dependent effect of Mcc950 on HRECs in 30 mM glucose condition for 72 h. Data are shown as the mean±S.E.M., n=3 technical replicates. One-way ANOVA followed by Tukey's multiple comparison test. *P<0.05, #P<0.01 versus control.

In vivo MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. [1]


Animal Research:


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  • Animal Models: C57BL/6 mice
  • Dosages: 50 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Water 85 mg/mL (199.31 mM)
DMSO Insoluble
Ethanol '40 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 426.46


CAS No. 256373-96-3
Storage powder
in solvent
Synonyms CRID3 sodium salt
Smiles CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID