research use only

Mibefradil dihydrochloride Calcium Channel antagonist

Cat.No.E1705

Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a nondihydropyridine antagonist of Ca++ channel, it reversibly inhibits the T-type and L-type currents with IC50 values of 2.7 μM and 18.6 μM, respectively. It increases coronary blood flow during ischemia and decreases smooth muscle proliferation after vascular injury, making it useful for congestive heart failure research.
Mibefradil dihydrochloride Calcium Channel antagonist Chemical Structure

Chemical Structure

Molecular Weight: 568.55

Quality Control

Chemical Information, Storage & Stability

Molecular Weight 568.55 Formula

C29H38FN3O3.2ClH

Storage (From the date of receipt)
CAS No. 116666-63-8 Download SDF Storage of Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map